Download YEW Wen Shan

Wen Shan YEW
Associate Professor
Department of Biochemistry
MD7 #05-08, 8 Medical Drive
Singapore 117597
Tel: 65168624, Email: [email protected]
Website: http://www.med.nus.edu.sg/bch/bchyws.htm
Lab page: http://www.med.nus.edu.sg/bch/pi/bchyws
Program page: http://syncti.org/
MAJOR RESEARCH INTERESTS
1. Defining Synthetic Enzymology as an enabling platform for the Construction of Next-Generation
Synthetic Biology solutions for Pharma and Consumer Businesses.
2. Using Synthetic Enzymology to discover and develop novel therapeutic biomolecules, in the
areas of infectious diseases, metabolic disorders, cancer and aging.
3. Developing anti-virulence Quorum-Based Technology for use in the biomedical industry.
4. Using Synthetic Lixiviant Enzymology for Biomining of Electronic Wastes for Environmental
Sustainability.
5. Development of Lead Compounds Targeting Enzymes involved in Metabolic Cancer.
6. Using Synthetic Enzymology for the Construction of Therapeutic (Probiotic) Cells for the
Treatment of Metabolic Diseases and Infectious Diseases.
SELECTED PUBLICATIONS
1. Go, M.K., Wongsantichon, J., Cheung, V.W.N., Chow, J.Y., Robinson, R.C., and Yew, W.S. (2015)
Synthetic Polyketide Enzymology: Platform for Biosynthesis of Novel Anti-Microbial Polyketides. ACS
Catalysis 5(7): 4033–4042.
2. Cheung, V.W.N., Xue, B., Hernandez-Valladares, M., Go, M.K., Tung, A., Aguda, A.H., Robinson, R.C.,
and Yew, W.S. (2014) Identification of Polyketide Inhibitors Targeting 3-Dehydroquinate Dehydratase in
the Shikimate Pathway of Enterococcus faecalis. PLoS One 9(7):e103598.
3. Odokonyero, D., Sakai, A., Patskovsky, Y., Malashkevich, V.N., Fedorov, A.A., Bonanno, J.B., Fedorov,
E.V., Toro, R., Agarwal, R., Wang, C., Ozerova, N.D.S., Yew, W.S., Sauder, J.M., Swaminathan, S.,
Burley, S.K., Almo, S.C., and Glasner, M.E. (2014) Loss of Quaternary Structure is Associated with
Rapid Sequence Divergence in the OSBS Family. Proc Natl Acad Sci 111, 8535-8540.
4. Go, M.K., Zhang, W.C., Lim, B., and Yew, W.S. (2014) Glycine Decarboxylase is an Unusual Amino
Acid Decarboxylase Involved in Tumorigenesis. Biochemistry 53, 947-956.
5. Chow, J.Y., Yang, Y., Tay, S.B., Chua, K.L., and Yew, W.S. (2014) Disruption of Biofilm Formation by
the Human Pathogen Acinetobacter baumannii using Engineered Quorum-quenching Lactonases.
Antimicrob Agents Chemother. 58, 1802-1805.
6. Tay, S.B., Natarajan, G., Rahim, M.N., Tan, H.T., Chung, M.C., Ting, Y.P., and Yew, W.S. (2013)
Enhancing gold recovery from electronic waste via lixiviant metabolic engineering in Chromobacterium
violaceum. Sci Rep. 3, 2236. doi: 10.1038/srep02236.
7. Xue, B., Chow, J.Y., Baldansuren, A., Yap, L.L., Gan, Y.W., Dikanov, S.A., Robinson, R.C., and Yew,
W.S. (2013) Structural Evidence of a Productive Active Site Architecture for an Evolved Quorumquenching GKL Lactonase. Biochemistry 52, 2359-2370.
8. Go, M.K., Chow, J.Y., Cheung, V.W.N., Lim, Y.P., and Yew, W.S. (2012) Establishing a Toolkit for
Precursor-directed Polyketide Biosynthesis: Exploring Substrate Promiscuities of Acid-CoA Ligases.
Biochemistry 51, 4568-4579.
9. Chow, J.Y., Xue, B., Lee, K.H., Tung, A., Wu, L., Robinson, R.C., and Yew, W.S. (2010) Directed
evolution of a thermostable quorum-quenching lactonase from the amidohydrolase superfamily. J Biol
Chem. 285, 40911-40920.
10. Chow, J.Y., Long, W., and Yew, W.S. (2009) Directed Evolution of a Quorum-Quenching Lactonase
from Mycobacterium avium subsp. paratuberculosis K-10 in the Amidohydrolase Superfamily.
Biochemistry 48, 4344-4353.