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Chester Drum M.D., Ph.D.
Asst. Prof., YLLSoM
14 Medical Drive, 08-02r
[email protected]
office ph: 66015010
MAJOR RESEARCH INTERESTS
Pharmacokinetics and clinical trials
Protein engineering and Nanotechnology
Synthetic biology
Mass spectroscopy and clinical robotics
Clinical biomarker discovery
SELECTED PUBLICATIONS
1. Patra A, Ding T, Engudar G, Yi W, Dykas M, Liedberg B, Kah J, Venkatesan T, Drum CL.
Component Specific Analysis of Plasma Protein Corona Formation On Gold Nanoparticles Using
Multiplexed Surface Plasmon Resonance.(in press) Small
2. Drum CL. System-level prescriptions for adaptive drug licensing. Science Translational
Medicine. 2015 Mar 4;7(277):277ec36.
3. Chan JM, Wong KHK, Richards AM, Drum CL. Microengineering in cardiovascular research:
new developments and translational applications. cardiovascular research. 2015 Feb 17. (editor’s
choice)
4. Ding T, Hong M, Richards AM, It Wong Ten, Zhou X, Drum CL. Quantification of a Cardiac
Biomarker in Human Serum Using Extraordinary Optical Transmission (EOT). PLoS ONE. 2015
Mar 16;10(3):e0120974.
5. Eichler H-G, Oye K, Baird LG, Abadie E, Brown J, Drum CL, et al. Adaptive licensing: taking
the next step in the evolution of drug approval. Clin Pharmacol Ther. 2012 Mar;91(3):426–37.
6. Chan JM, Rhee J-W, Drum CL, Bronson RT, Golomb G, Langer R, et al. In vivo prevention of
arterial restenosis with paclitaxel-encapsulated targeted lipid-polymeric nanoparticles. Proc Natl
Acad Sci USA. National Acad Sciences; 2011 Nov 29;108(48):19347–52.
7. Drum CL, Yan S-Z, Bard J, Shen Y-Q, Lu D, Soelaiman S, et al. Structural basis for the activation of
anthrax adenylyl cyclase exotoxin by calmodulin. Nature. 2002 Jan 24;415(6870):396–402.
8. Drum CL, Yan SZ, Sarac R, Mabuchi Y, Beckingham K, Bohm A, et al. An extended
conformation of calmodulin induces interactions between the structural domains of adenylyl
cyclase from Bacillus anthracis to promote catalysis. J Biol Chem. American Society for
Biochemistry and Molecular Biology; 2000 Nov 17;275(46):36334–40.
9. Shen Y, Guo Q, Zhukovskaya NL, Drum CL, Bohm A, Tang W-J. Structure of anthrax edema
factor-calmodulin-adenosine 5'-(alpha,beta-methylene)-triphosphate complex reveals an alternative
mode of ATP binding to the catalytic site. Biochem Biophys Res Commun. 2004 Apr
30;317(2):309–14.
10. Benzinger GR, Drum CL, Chen LQ, Kallen RG, Hanck DA, Hanck D. Differences in the
binding sites of two site-3 sodium channel toxins. Pflugers Arch. 1997 Nov;434(6):742–9.
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