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Download Supramolecular Multifunctional Nano-carriers for Cancer Therapeutic and Diagnostic Applications
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NUS Graduate School for Integrative Sciences and Engineering Research Project Write-up Title of Project : Supramolecular Multifunctional Nano-carriers for Cancer Therapeutic and Diagnostic Applications Name of Supervisor : Assoc Prof Li Jun Contact Details: Department of Bioengineering, Faculty of Engineering, Block EA, #02-06, NUS (Email: [email protected]; Tel: 65167273; http://www.bioeng.nus.edu.sg/people/PI/Lijun) Short Description The project aims to develop novel and innovative biomaterials for efficient cancer therapeutic and diagnostic applications. For such purposes, it is important to develop multifunctional carrier systems that can harness and combine different mechanisms synergistically to maximize the therapeutic effects of the delivered drug and gene, and also impart bioimaging functions to the carriers through incorporating functional components such as fluorescent and MRI probes, and magnetic or other metal nanoparticles into the carrier systems. We have recently demonstrated one example of developing a hybrid nanocarrier system based on quantum dot and supramolecular self-assembly for co-delivery of chemotherapeutic drug and gene, and also for cellular imaging. Based on our experience in supramolecular chemistry and polymer synthesis, the student will have opportunity and freedom to develop novel hybrid nano-carrier systems and work on their physicochemical characterization and applications for cancer treatment.
