Download Curriculum Vitae

April 2016
MISHRA, PARAS K.
PARAS KUMAR MISHRA, PH.D.
CURRICULUM VITAE
HOME ADDRESS
17260 Pine Street
Omaha, NE. 68130
CAMPUS ADDRESS
Department of Cellular and Integrative Physiology
University of Nebraska Medical Center
984575 Nebraska Medical Center
Omaha, NE. 68198-5850
Phone: (402) 559-8524
Fax: (402) 559-4438
Email: [email protected]
EDUCATION
July 1995 to May 1999
Lalit Narayan Mithila University, India
B.Sc. in Zoology (Honors)
June 1999 to May 2001
Banaras University, India
M.Sc. in Zoology
June 2001 to October 2006
Banaras University, India
Ph.D. in Zoology
Dissertation: Evolutionary Studies in Drosophila Interspecific hybridization among four species
of the Drosophila bipectinata complex
POSTDOCTORAL TRAINING
March 2007 to May 2008
Postdoctoral Fellow
Department of Biology, Emory University, Atlanta, Georgia
June 2008 to March 2010
Research Associate
Department of Physiology & Biophysics, University of Louisville, Louisville, Kentucky
1
April 2016
MISHRA, PARAS K.
ACADEMIC APPOINTMENTS
July 2015-
Associate Professor, Department of Cellular & Integrative Physiology, University
of Nebraska Medical Center, Omaha, Nebraska
May 2013 – June 2015
Assistant Professor, Department of Cellular & Integrative Physiology,
University of Nebraska Medical Center, Omaha, Nebraska
April 2010–April 2013
Assistant Professor, Department of Physiology & Biophysics, University of
Louisville, Louisville, Kentucky
June 2008-March 2013
Research Associate, Department of Physiology & Biophysics, University of
Louisville, Louisville, Kentucky
March 2007-May 2008
Postdoctoral Fellow, Department of Biology, Emory University, Atlanta,
Georgia
OTHER APPOINTMENTS OR POSITIONS
July 2015-
Courtesy Associate Professor, Department of Anesthesia, University of Nebraska
Medical Center, Omaha, Nebraska
May 2013- June 2015
Courtesy Assistant Professor, Department of Anesthesia, University of
Nebraska Medical Center, Omaha, Nebraska
GRANT SUPPORT
Current Grant Support 1.
National Institutes of Health RO1 grant: HL113281
Inflammation, miRNA, and autophagy in diabetes
P. K. MISHRA, Principal Investigator. (45% effort)
Total direct amount of award: $1,250,000; first year: $250,000
Period of support: 01/07/13 to 07/31/18
2.
National Institutes of Health RO1 grant: HL116205
Exercise and H2S mitigate homocysteine mediated beta2-adrenergic receptor
dysfunction in diabetes
P. K. MISHRA, Principal Investigator. (45% effort)
Total direct amount of award: 1,238,000; first year: $238,000
Period of support: 09/01/13 to 06/30/18
3. National Institutes of Health RO1 grant: HL126797
Cardiac Sympathetic Afferent Denervation and Remodeling in Heart Failure
P.K. MISHRA, Co-Invest. (3% effort), PI – I.H. Zucker
Total direct amount of award: $1,647,175; first year: $329,435
Period of support: 12/18/15 to 11/30/19
Pending Grant Support 1.
National Institutes of Health RO1 grant: HL134819
Alleviating mitochondrial abnormalities by miRNA in diabetic hearts
P. K. MISHRA, Principal Investigator.
Total direct amount of award: $1,250,000; first year: $250,000
2
April 2016
MISHRA, PARAS K.
2.
American Heart Association Midwest Affiliate Postdoctoral Fellowship:16POST27260104
Mitochondrial abnormality and its regulation by miRNA in diabetic hearts
P.K. MISHRA Sponsor, PI, S. S. Nandi
Total direct amount of award: $ 106,372; first year: $ 52,244
Previous Grant Support –
1.
American Heart Association Beginning Grant-In-Aid: 11 BGIA 7690055
Role of MMPs in miRNA mediated diabetic cardiomyopathy
P. K. MISHRA, Principal Investigator. (30% effort)
Total direct amount of award: $120,000; first year: $60,000
Period of support: 07/01/11 to 04/30/13
2.
National Institutes of Health RO1 grant: HL88012
Implications of Endothelial- myocytes uncoupling in cardiac arrhythmia
P.K. MISHRA, Co-Invest. (10% effort), PI – S.C. Tyagi
Total direct amount of award: $1,250,000; first year: $250,000
Period of support: 04/01/07 to 03/31/11
CONSULTING POSITIONS
Study Sections, Regular Member 2011 - 2012
American Heart Association (National)
Study section- Basic Cell Genetics and Epigenetics
Regular Reviewer
2013
National Institutes of Health (NHLBI)
Study section- NIDDK, Diabetes complications consortium
Ad-hoc Reviewer
2014-
American Heart Association (National)
Study section- Basic Cell Genetics and Epigenetics
Regular Reviewer (September cycle)
2014
American Heart Association (National)
Study section- Clinical, Behavioral Science
Ad-hoc Reviewer (April cycle)
2015
American Heart Association (National)
Study section- Innovative Research Grant, Basic Sciences 1
Ad-hoc Reviewer (October cycle)
2016
National Institutes of Health (NHLBI)
Study section- Cardiac Contractility Heart Failure (CCHF)
Ad-hoc Reviewer (February cycle)
3
April 2016
MISHRA, PARAS K.
Reviewer of International Research Grant 2015
Diabetes UK Research Grant: Grant application from University of Oxford, United
Kingdom.
Editor of Book
2010
Stem Cells: Organogenesis and Cancer
Publisher: Transword Research Network
ISBN: 978-81-7895-487-5
Co-Editor
Guest Editor of Journals
2011
2013
Journal of Diabetes and Metabolism. Manuscript: ACRGROUP-13-118
Journal of Diabetes and Metabolism. Manuscript: ACRGROUP-11-325
Senior Editor
2015
Cogent Medicine journal. Manuscript: COFENTMED -2015-0025
Associate Editor of Journal
1.
Journal of Molecular and Translational Research, 2015(http://www.jmtr.net/editorial-board.html)
Editorial Board Member of Journals
1.
Internal Medicine, 2011(http://www.omicsgroup.org/journals/editorialboard-internal-medicine-open-access.php)
2.
Journal of Diabetes and Metabolism, 2011(http://www.omicsonline.org/editorialboard-diabetes-metabolism-open-access.php)
3.
International Journal of Physiology, Pathophysiology and Pharmacology, 2011(http://www.ijppp.org/editorial_board.html)
4.
Advances in Medicine, 2011(http://www.hindawi.com/journals/amed/editors/endocrinology/)
5.
Frontiers in Oxidant Physiology, 2014(http://journal.frontiersin.org/journal/physiology/section/oxidant-physiology#editorial-board)
6.
Cogent Medicine, 2015(http://cogentoa.tandfonline.com/page/aboutJournal?journalCode=oamd20)
7.
Integrative Obesity and Diabetes, 2015(http://oatext.com/Integrative-Obesity-and-Diabetes-IOD.php#Editorial_Board)
4
April 2016
MISHRA, PARAS K.
8.
Cardiovascular Regenerative Medicine, 2015(http://www.smartscitech.com/index.php/CRM/about/editorialTeam)
9.
EC Endocrinology and Metabolic Research, 2015(https://www.ecronicon.com/ECEMR-EB.php)
10.
Molecular and Cellular Biochemistry, 2015(http://www.springer.com/life+sciences/biochemistry+%26+biophysics/journal/11010/PS2?det
ailsPage=editorialBoard)
11.
AJP-Heart and Circulatory Physiology, 2015(http://ajpheart.physiology.org/edboard)
Ad hoc Reviewer for Journals 1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
13.
14.
15.
16.
17.
18.
19.
20.
21.
22.
23.
24.
25.
26.
27.
28.
29.
30.
31.
32.
American Journal of Physiology: Heart and Circulatory Physiology
American Journal of Physiology: Regulatory, Integrative & Comparative Physiology
BBA- Molecular Basic of Disease
BioMed Research International
Canadian Journal of Physiology & Pharmacology
Cardiovascular Diabetology
Cardiovascular Research
Cell Biochemistry and Biophysics
Circulation
Comparative Biochemistry and Physiology
Current Diabetes Review
Diabetes Research and Clinical Practice
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
European Journal of Heart Failure
Food and Chemical Toxicity
Genome
International Journal of Biology
International Journal of Molecular Medicine
Journal of Cellular and Molecular Medicine
Journal of Cardiovascular Translational Research
Journal of Molecular and Cellular Cardiology
Journal of Stem Cell Research and Therapy
Life Sciences
Molecular and Cellular Biochemistry
Molecular Biology Reports
Neurochemistry International
Oxidative Medicine and Cellular Longevity
Plos One
Recent Patents on Biotechnology
Reproductive Sciences
Toxicological Sciences
Tissue Engineering
5
April 2016
MISHRA, PARAS K.
HONORS AND AWARDS
Travel Award: Department of Science and Technology, India (2005)
Travel Award: Indian National Science Academy, India (2005)
Top 10% of Accepted Abstract in AHA, High Blood Pressure Research 2010
Invited Presentation, AHA Scientific Session Best of HBPR2010 (2010)
Finalist, AHA, Harry Goldblatt New Investigator Award (2010)
Satu Somani Award in Physiology, Association of Scientists of Indian Origin in America (2011)
American Heart Association- Beginning-Grand-In-Aid (2011-2013)
Editorial Board (member), American Journal of Biochemistry and Biotechnology (2011- 2013)
Editorial Board (member), International Journal of Physiology, Pathophysiology and Pharmacology
(2011-)
Reviewer: American Heart Association
National, Basic Cell Genetics and Epigenetics Review Committee (2011-12)
Best Poster Award, 2nd International Conference on H2S Biology and Medicine (2012)
Editorial Board (member), WebMed Central (2012-)
The National Institutes of Health – RO1 award (2013 - 18), First NIH Grant.
The National Institutes of Health – RO1 award (2013 - 18), Second NIH Grant.
Ad-hoc Reviewer: The National Institutes of Health,
NIDDK, Diabetes Complications Consortium Review Committee (2013)
Editorial Board (member), Advances in Medicine (2013-)
Editorial Board Member, Frontiers in Oxidative Physiology (2013-)
Ad-hoc Reviewer: American Heart Association
Clinical and Behavioral Science Review Committee (2014)
Reviewer: American Heart Association
National, Basic Cell Genetics and Epigenetics Review Committee (2014)
Editorial Board (member), International Journal of Diabetes and Clinical Research (2014-)
Fellow of American Physiological Society (FAPS), Cardiovascular Section (2014)
University of Nebraska Medical center New Investigator Award (2014)
6
April 2016
MISHRA, PARAS K.
Editorial Board (member) CV Network (2015)
Reviewer of a Grant proposal from Diabetes UK. Research Grant proposal was from Oxford University,
United Kingdom (2015)
Member of APS Cardiovascular Section Fellowship Committee (2015)
Editorial Board (member), EC Endocrinology and Metabolic Research (2015)
Editorial Board (member), Molecular and Cellular Biochemistry (2015)
Editorial Board (member), American Journal of Physiology- Heart and Circulatory Physiology (2015).
Associate Editor of Journal of Molecular and Translational Research (2015).
Ad-hoc Reviewer: The National Institutes of Health,
NHLBI, Cardiac Contractility and Heart Failure, CCHF (2016)
MEMBERSHIP AND OFFICES IN PROFESSIONL SOCIETIES
Society Memberships American Physiological Society - Cardiovascular section, 2010-present
American Heart Association - Council on Basic Cardiovascular Sciences, 2009- 2013
Nebraska Physiological Society, 2013-present.
American Heart Association - Council on Hypertension, 2014-present
Service at Society Meetings –
Chair of the Featured topic "MicroRNA and stem cell in muscle pathology”, organized by American
Physiological Society, Muscle Biology, Experimental Biology meeting, Boston, April 2013
Co-chair of the Featured topic "Matrix metalloproteinases in the cardiovascular system”, organized by
American Physiological Society Cardiovascular Section, Experimental Biology meeting, Boston, April
2013
Chair of the session on “Cardiovascular Research-III” organized by Target Meeting, 3rd World Diabetes
and Obesity Conference, Online conference, September 2013
Organizing committee member of “3rd International Conference on Clinical and Experimental
Cardiology” organized by Omics group, Chicago, April 2013
(http://www.omicsgroup.com/conferences/cardiology-2013/committee.php)
Chair of the Featured topic "Autophagy and miRNA in diabetic heart failure”, organized by American
Physiological Society Cardiovascular Section, Experimental Biology meeting, held in Boston in April
2015
7
April 2016
MISHRA, PARAS K.
Organizing committee member of conference entitled “Euro Weight Loss-2015” to be held in Frankfurt,
Germany from August 18-20
(http://weightloss.global-summit.com/europe/organizing-committee.php)
Member of Fellowship committee of American Physiological Society, Cardiovascular Section. May
2015Organizing committee member of Annual meeting of the international academy of cardiovascular
sciences (IACS): North American Section” held in Omaha, September 10-12, 2015
(http://www.cvent.com/events/annual-meeting-of-the-international-academy-of-cardiovascularsciences-north-american-section/staff 587863adfa2c4549b7dd80c92b13003a.aspx)
Co-chair of the session entitled “Dr. Bruce McManus Young Investigator Presentations” in the Annual
meeting of the international academy of cardiovascular sciences (IACS): North American Section” held
in September 11, 2015
Moderator of the session entitled “Autophagy and Cardiovascular Disease” American Heart
Association Scientific Session, held in Orlando, November 2015
Organizing committee member of “9th Global Diabetologists Annual Meeting and Medicare Expo” to
be held from June 6-8, 2016 in Dallas, Texas.
Scientific Judge in conference/ symposium –
Poster Presentation of Postdoctoral and Doctoral Fellows and Medical Students in “Research
Louisville” organized by University of Louisville, Louisville, Kentucky, 2009-2012.
Third Annual Graduate Research Symposium at University of Louisville, Louisville, Kentucky, 2011.
Midwest Student Biomedical Research Forum, UNMC, Omaha, NE, 2015.
Abstract Judge for four awards in “Annual meeting of the international academy of cardiovascular
sciences (IACS): North American section” held in Omaha, September 10-12, 2015.
COMMITTEE ASSIGNMENTS
University of Louisville
Research committee for Graduation summa cum laude of Mr. Jonathan Vacek (2011)
Research committee for MS for Ms. Nicole S Stivers (2011).
8
April 2016
MISHRA, PARAS K.
University of Nebraska Medical Center
Departmental committees:
Graduate supervisory research committee member for Derek Passer 2013Graduate external research committee member for Yuan Ying, 2014
Alice Cumming Award Committee, 2014Review committee for nomination of A. Ross McIntyre Cardio-Renal seminar, 2014Faculty search Committee, 2014In-Charge of Departmental Seminar Program, effective from January 2016.
University level committees:
Mouse Genome Engineering Core Advisory Committee, 2014Internal Advisory Board committee member of COBRE proposal “Immunobiology of
cardiothoracic, vascular and metabolic diseases” submitted by PI’s from UNMC and Creighton
University, 2014.
Mentor of a T32-pre-doctoral training grant application entitled” Nutrition, Non-coding RNAs
and Extracellular Vesicles” organized by UNL and UNMC PI’s. Submitted on May 22, 2015.
An investigator in the Basic Science collaborative proposal led by Dr. Daniel R. Anderson at
UNMC for American Heart Association’s Strategically Focused Research Network grant” due
on February 2016.
An investigator in the collaborative grant proposal led by Dr. Sasha K. Shillcutt at UNMC. The
tentative title of the proposal is: The relationship between left ventricular diastolic dysfunction
and aortic stenosis in patients undergoing aortic valve replacement. It is supposed to be
submitted by early 2016.
Member of Research and Development Committee, 2015- 2018.
Organizing committee of national and international conferences
1. 3rd International Conference on Clinical and Experimental Cardiology, Chicago, April 2013.
2. Euro Weight Loss-2015 Frankfurt, Germany, August, 2015.
3. Annual meeting of the international academy of cardiovascular sciences (IACS): North
American Section, Omaha, September, 2015.
4. 9th Global Diabetologists Annual Meeting and Medicare Expo, Dallas, June, 2016.
9
April 2016
MISHRA, PARAS K.
Presentations
Invited Symposium Presentations (Local, National and International Meetings)
1. International symposium on “Population genetics and chromatin dynamics”
Banaras Hindu University, Varanasi, India. January 22-23, 2012.
2. The cardiovascular Forum for Promoting Centers of Excellence and Young Investigators.
Louisville, Kentucky, August 15-17, 2013.
3. 2nd Cardiovascular Forum for Promoting Centers of Excellence and Young Investigators.
Winnipeg, Manitoba, Canada, September 4-6, 2014.
4. Annual meeting of the international academy of cardiovascular sciences (IACS): North American
section, Omaha, Nebraska, September 1012, 2015.
Invited to Chair Sessions (National and International Meetings)
1. Chair of the session on “Cardiovascular Research-II”, 3rd World Diabetes and Obesity Conference,
Target online meeting, September 2013.
2. Chair of the session “Dr. Bruce McManus Young Investigator Presentations”, Annual meeting of
the international academy of cardiovascular sciences (AIACS): North American Section,
September 11, 2015.
3. Moderator of the session “Autophagy and cardiovascular diseases”, American Heart Association
Scientific Session, November 9, 2015.
Invited Seminar Presentations:
(National & International Academic Institutions in chronological order)
1. Department of Physiology – November 8, 2012
Wayne State University, Detroit, Michigan
Title of talk: "MiRNA and MMP9 in the diabetic heart"
2. Molecular Cardiology Faculty Seminar- January 9, 2013
Cleveland Clinic Learner Research Institute, Ohio
Title of talk: "MiRNA and MMP9 in the diabetic heart"
3. Department of Cellular and Integrative Physiology – January 22, 2013
University of Nebraska Medical Center, Omaha, Nebraska
Title of talk: "MiRNA and MMP9 in the diabetic heart"
4. Institute of Cellular Therapeutic – January 29, 2013
University of Louisville, Louisville, Kentucky
Title of talk: "Role of MMP9 in diabetic cardiomyopathy"
10
April 2016
MISHRA, PARAS K.
5. Department of Surgery Forum – September 11, 2013
University of Nebraska Medical Center, Omaha, Nebraska
Title of talk: "Multifaceted role of miR-133 in the heart"
6. Department of Internal Medicine – January 31, 2014
University of Nebraska Medical Center, Omaha, NE
Title of talk: "Novel regulatory mechanisms of diabetic cardiomyopathy"
7. MD/Ph. D. Scholar Program Luncheon meeting – April 3, 2014
University of Nebraska Medical Center, Omaha, NE
Title of talk: "Role of miRNA in cardiac remodeling"
8. Department of Pharmacology - April 18, 2014
University of Nebraska Medical Center, Omaha, NE
Title of talk: "Mechanism of pathological cardiac remodeling in diabetics"
9. The Nebraska Gateway to Nutrigenomics seminar series – October 8, 2014
University of Nebraska Lincoln, Lincoln, NE
Title of talk: "Regulating the regulators of autophagy in diabetic hearts"
10. Cardiology Grand round, Division of Cardiology- February 25, 2015
University of Nebraska Medical Center, Omaha, NE
Title of talk: "Autophagy and miRNA in diabetic heart failure"
Oral presentation at International and national conferences:
1.
AHA, High Blood Pressure Research, Washington DC, November 10, 2010
Harry Goldblatt Award Lecture
Title of talk: "Ablation of MMP9 ameliorates miR-1, and miR-133 mediated cardiac
dysfunction in Insulin2 mutant diabetic mice"
2.
Experimental Biology Meeting, Boston. April 9-13, 2011
Session: Fibroblast- cardiomyocyte signaling
Title of talk: "Exercise ameliorates diabetic cardiomyopathy by inducing beta2-adrenergic
receptors and miR-133a, and attenuating MMP9"
3.
International Symposium on Population Genetics and Chromatin Dynamics, Banaras Hindu
University, Varanasi, India, January 22, 2012.
Title of talk: "Genetic deletion of MMP9 induces miRNA and ameliorates heart failure in
diabetics”
4.
Experimental Biology Meeting, San Diego, California. April 21-25, 2012
Session: Effect of exercise and nutritional perturbations on cumulative muscle protein synthesis.
Title of talk: "Exercise mitigates beta2-adrenergic receptor dysfunction by decreasing
homocysteine in diabetes"
5.
Experimental Biology Meeting, Boston. April 20-24, 2013
Session: MicroRNA and stem cell in muscle pathophysiology
Title of talk: "Ablation of MMP9 ameliorates epigenetic modifications and mitigates diabetic
cardiomyopathy"
11
April 2016
MISHRA, PARAS K.
6.
2nd Cardiovascular Forum for Promoting Centers of Excellence and Young Investigators.
Winnipeg, Manitoba, Canada, September 4-6, 2014
Title of talk: “Cardioprotective role of miR-133 in diabetic hearts”
7.
Annual meeting of the international academy of cardiovascular sciences (IACS): North
American section, Omaha, Nebraska, September 11, 2015.
Title of talk: “Novel cardioprotective role of miR-133a”
PUBLICATIONS
Publications 1.
MISHRA, PK, Singh BN. Genetic basis of hybrid male sterility among three closely related species
of Drosophila. Indian Journal of Experimental Biology 43:455-461, 2005.
2.
MISHRA PK, Singh BN. Why hybrid males are sterile in Drosophila? Current Science 89:18131819, 2005.
3.
MISHRA, PK, Singh BN. Genetic interactions underlying hybrid male sterility in the Drosophila
bipectinata species complex. Genes and Genetic Systems 81: 193-200, 2006.
4.
MISHRA, PK, Singh BN. Unique phenotypes and variation in the sex comb patterns and their
evolutionary implications in the Drosophila bipectinata species complex (Diptera: Drosophilidae).
European Journal of Entomology 103: 805-815, 2006.
5.
MISHRA, PK, Singh BN. Drosophila bipectinata species complex: study of phylogenetic
relationship among four members through the analyses of morphology of testes and seminal
vesicles. Journal of Zoological Systematics and Evolutionary Research 44: 175-179, 2006.
6.
MISHRA, PK, Singh BN. Assessing the putative roles of X-autosome and X-Y interactions in
hybrid male sterility of the Drosophila bipectinata species complex. Genome 50: 653-659, 2007.
7.
Kumar M, Tyagi N, Moshal KS, Sen U, Kundu S, MISHRA PK, Givvimani S, Tyagi SC.
Homocysteine decreases blood flow to the brain due to vascular resistance in carotid artery.
Neurochemical International 53:214-219, 2008.
8.
MISHRA PK, Tyagi N, Kundu S, Tyagi SC. MicroRNAs are involved in homocysteine induced
cardiac remodeling. Cell Biochemistry and Biophysics 55: 153-162, 2009.
9.
MISHRA PK, Tyagi N, Kumar M, Tyagi SC, MicroRNA as a therapeutic target for cardiovascular
disease. Journal of Cellular and Molecular Medicine 13: 778-789, 2009.
10. Tyagi N, MISHRA PK, Tyagi SC, Homocysteine, hydrogen sulfide, and NMDA receptor in heart
failure. Indian Journal of Biochemistry and Biophysics 46: 441-446, 2009.
11. Kundu S, Kumar M, Sen U, MISHRA PK, Tyagi N, Metreveli N, Lominadze D, Rodriguez W, Tyagi
SC. Nitrotyrosylation, remodeling and endothelial-myocyte uncoupling in iNOS, cystathionine
beta synthase (CBS) knockouts and iNOS/CSB double knockout mice. Journal of Cell
Biochemistry 106: 119-126, 2009.
12. Moshal KS, Kumar M, Tyagi N, MISHRA PK, Metreveli N, Rodriguez WE, Tyagi SC. Restoration
of contractility in hyperhomocysteinemia by cardiac –specific deletion of NMDA-R1. American
Journal of Physiology, Heart and Circulatory Physiology 296: H887-892, 2009.
12
April 2016
MISHRA, PARAS K.
13. MISHRA PK, Tyagi N, Sen U, Givvimani S, Tyagi SC. H2S ameliorates oxidative and proteolytic
stresses and protects the heart against adverse remodeling in chronic heart failure. American
Journal of Physiology, Heart and Circulatory Physiology 298: H451-456, 2010.
14. Sen U, MISHRA PK, Tyagi N, Tyagi SC. Homocysteine to hydrogen sulfide or hypertension. Cell
Biochemistry and Biophysics 57: 49-58, 2010.
15. MISHRA PK, Singh SR, Joshua IG, Tyagi SC. Stem cells as a therapeutic target for diabetes.
Frontiers of Bioscience. 15: 461-477, 2010.
16. Givvimani S, Tyagi N, Sen U, MISHRA PK, Qipshidze N, Munjal C, Vacek JC, Abe OA, Tyagi SC.
MMP2/TIMP2/TIMP4 Versus MMP9/TIMP3 in transition from compensatory hypertrophy and
angiogenesis to decompensatory heart failure. Archives of Physiology and Biochemistry 116: 6372, 2010.
17. MISHRA PK, Metreveli N, Tyagi SC. MMP9 gene ablation and TIMP4 mitigates PAR1 mediated
cardiomyocytes dysfunction: a plausible role of dicer and miRNA. Cell Biochemistry and
Biophysics 57: 67-76, 2010.
18. Qipshidze N, Metreveli N, MISHRA PK, Lominadze D, Tyagi SC. Hydrogen sulfide mitigates
cardiac remodeling during myocardial infarction via improvement of angiogenesis. International
Journal of Biology 8: 430-441, 2010.
19. MISHRA PK, Tyagi N, Sen U, Joshua IG, Tyagi SC. Synergism in hyperhomocysteinemia and
diabetes: role of PPAR gamma and tempol. Cardiovascular Diabetology 9: 49-62, 2010.
20. *MISHRA PK, Givvimani S, Metreveli N, Tyagi SC. Attenuation of beta2-adrenergic receptors and
homocysteine metabolic enzymes cause diabetic cardiomyopathy. Biochemical and Biophysical
Research Communication 15: 175-181, 2010. * Corresponding author.
21. Tyagi AC, Sen U, MISHRA PK*. Synergism of miRNA and stem cell: a novel therapeutic approach
for diabetic mellitus and cardiovascular diseases. Current Diabetes Reviews 7: 367-376, 2011.
*Corresponding author.
22. Givvimani S, Qipshidze N, Tyagi N, MISHRA PK, Sen U, Tyagi SC. Synergism between
arrhythmia and hyperhomocysteinemia in structural heart disease. International Journal of
Physiology, Pathophysiology and Pharmacology 3: 107-119, 2011.
23. Basu P, Qipshidze N, Sen U, Givvimani S, Munjal C, MISHRA PK, Tyagi SC. Chronic
hyperhomocysteinemia causes vascular remodeling by instigating vein phenotype in artery.
Archives of Physiology and Biochemistry 117: 270-282, 2011.
24. *MISHRA PK, Awe O, Metreveli N, Qipshidze N, Joshua IG, Tyagi SC. Exercise mitigates the
homocysteine- beta2 adrenergic receptor interactions to ameliorate contractile dysfunction in
diabetes. International Journal of Physiology, Pathophysiology and Pharmacology 3:97-106,
2011. * Corresponding author.
25. Sen U, Sathur PB, Kundu S, Givvimani S, Coley D, MISHRA PK, Qipshidze N, Tyagi N, Metreveli
N, Tyagi SC. Increased endogenous H2S generation by CBS, CSE, and 3MST gene therapy
improves ex vivo renovascular relaxation in hyperhomocysteinemia. American Journal of
Physiology, Cell Physiology 303: C41-51, 2012.
26. *MISHRA PK, Chavali V, Metreveli N, Tyagi SC. Ablation of MMP9 induces survival and
differentiation of cardiac stem cell into cardiomyocytes in the diabetic heart, a role of extracellular
matrix. Canadian Journal of Physiology and Pharmacology 90: 353-360, 2012. * Corresponding
author.
13
April 2016
MISHRA, PARAS K.
27. Chavali V, Tyagi SC, MISHRA PK*. MicroRNA-133a regulates DNA methylation in diabetic
cardiomyocytes. Biochemical and Biophysical Research Communication 425:668-672, 2012.
*Corresponding author.
28. Chavali V, Tyagi SC, MISHRA PK*. Predictors and prevention of diabetic cardiomyopathy.
Diabetes Metabolic Syndrome and Obesity: Targets and Therapy 6: 151-160, 2013.
*Corresponding author.
29. MISHRA PK, Givvimani S, Chavali V, Tyagi SC. Cardiac matrix: a clue for future therapy.
Biochemical Biophysical Acta, Molecular Basis of Disease 1832: 2271-2276, 2013.
30. Chavali V, Tyagi SC, MISHRA PK*. Differential expression of dicer, miRNA and inflammatory
markers in diabetic Ins2+/- Akita hearts. Cell Biochemistry and Biophysics 68: 25-35, 2014.
*Corresponding author.
31. Zheng H, Liu X, Li Y, MISHRA PK, Patel KP. Attenuated dopaminergic tone in the paraventricular
nucleus contributing to sympatho-excitation in rats with type2 diabetes. American Journal of
Physiology, Regulatory, Integrative, and Comparative Physiology 306: R138-148, 2014.
32. Nandi SS, MISHRA PK*. Harnessing fetal and adult genetic reprogramming for therapy of heart
disease. Journal of Nature and Science 1 (4): e71, 2015. * Corresponding author.
33. Kesherwani V, Nandi SS, Sharawat SK, Shahshahan HR, MISHRA PK*. Hydrogen sulfide
mitigates homocysteine mediated pathological remodeling by inducing miR-133a in
cardiomyocytes. Molecular and Cellular Biochemistry 404: 241-250, 2015. *Corresponding
author.
34. Kesherwani V, Chavali V, Hackfort BT, Tyagi SC, MISHRA PK*. Exercise ameliorates high fat
diet induced cardiac dysfunction by increasing interleukin 10. Frontiers in Physiology 6: 124, 2015.
*Corresponding author.
35. Nandi SS, Duryee MJ, Thiele GM, Anderson DR, MISHRA PK*. Induction of autophagy markers
is associated with attenuation of miR-133a in diabetic heart failure patients undergoing
mechanism unloading. American Journal of Translational Research 7(4) 683-696, 2015.
*Corresponding author.
36. Hackfort BT, MISHRA PK*. Emerging role of hydrogen sulfide-microRNA cross-talk in
cardiovascular disease. American Journal of Physiology, Heart and Circulatory Physiology. 310:
H802-H812, 2016. *Corresponding author.
Highlighted by Editor. Link: https://www.youtube.com/watch?v=9wrxjMV51r0
37. Prathipati P, Metreveli N, Nandi SS, Tyagi SC, MISHRA PK*. Ablation of matrix
metalloproteinase-9 prevents cardiomyocytes contractile dysfunction in diabetics. Frontiers in
Physiology 7:93, 2016. *Corresponding author.
Chapter in books published
38. Moshal KS, Kumar M, Tyagi N, MISHRA PK, Kundu S, Tyagi SC. Oxidative and proteolytic stress
in homocysteine associated cardiovascular diseases. In H. Sauer et al (Eds); Studies on
cardiovascular disorders. Springer Science+ Business Media, LLC, 139-148, 2010.
39. *MISHRA PK, Singh SR, Sharma R, Tyagi SC. Stem cell for myocardial regeneration. In Singh
SR et al (Eds); Stem Cells: organogenesis and cancer. Transword Research Network, 119-126,
2010. * Corresponding author.
40. *MISHRA PK, Kuypers NJ, Singh SR, Diaz N, Chavali V, Tyagi SC. Cardiac stem cell niche,
14
April 2016
MISHRA, PARAS K.
MMP9, and culture and differentiation of embryonic stem cells. In Kursad T (Ed): Stem cells and
niche. Springer, 1035: 153-163, 2013. * Corresponding author.
41. *MISHRA PK, Tyagi SC. MicroRNOmics of diabetic cardiomyopathy. In Turan B and Dhalla NS
(Eds): Diabetic cardiomyopathy, Springer 9: 179-188, 2014. * Corresponding author.
42. Chavali V, Nandi SS, Singh SR, MISHRA PK*. Generating double knockout mice to model genetic
intervention in diabetic cardiomyopathy in humans. In Singh SR (Ed): Mouse genetics: methods
and protocols, Springer, 1194:385-400, 2014. * Corresponding author.
Editorial published
43. MISHRA PK. Is miR-133a a promising therapeutic target for heart failure? Journal of Diabetes
and Metabolism 5: 8: e118, 2014.
Articles submitted for publications1. Nandi SS, Zheng H, Sharma NS, Shahshahan HR, Patel KP, MISHRA PK*. Lack of miR-133a
decreases contractility in diabetic hearts: a role for novel cross-talk between tyrosine
aminotransferase and tyrosine hydroxylase. Diabetes. Under Revision. *Corresponding author.
2. Nandi SS, MISHRA PK*. MicroRNA-133a regulates autophagy and mitophagy in diabetic hearts.
Submitted to “Autophagy” on May 13th. Under revision for resubmission. *Corresponding author.
Book published 1. Stem Cells: Organogenesis and Cancer. Editors: Singh SR, MISHRA PK and Hou SX. Publisher:
Transword Research Network, ISBN: 978-81-7895-487-5, 2010.
Abstracts published1. MISHRA PK, Metreveli N, Givvimani S, Kundu S, Tyagi N, Qipshidze N, Sen U, Basu P, Abe OA,
Gillespie WM, Munjal C, Vacek J, Tyagi SC. Down regulation of dicer involved in MMP-9
mediated cardiomyocytes dysfunction. Hypertension, 54: e26 - e127; 2009.
2. Kumar M, Givvimani S, Sathnur PB, MISHRA PK, Kundu S, Rodriguez-Alvarez WE, Tyagi N, Sen
U, Tyagi SC. Cerebro-protective role of tetra-hydro curcumin in hyperhomocysteinemic ischemic
mine by regulating NF-kB. FASEB J, 23: 614.7; 2009.
3. Tyagi N, Givvimani S, Kumar M, Kundu S, Gillespie W M, MISHRA PK, Sathnur P, Lominadze
D, Sen U, Tyagi SC. Activation of GABA- receptor Protects Mitochondria and Reduces Cerebral
ischemia. FASEB J, 23: 614.8; 2009.
4. MISHRA PK, Tyagi N, Kumar M, Kumar M, Kundu S, Givvimani S, Sen U, Tyagi SC. Role of
microRNAs in homocysteine-induced oxidative stress. FASEB J, 23: 1038.9; 2009.
5. MISHRA PK, Metreveli N, Givvimani S, Panguluri SK, Sen U, Tyagi N, Basu P, Munjal C, Joshua
IG, Tyagi SC. Ablation of MMP-9 ameliorates miR-1 and -133 mediated cardiac dysfunction in
insulin2 mutant diabetic mice. Hypertension, 56: e50 - e166; 2010.
15
April 2016
MISHRA, PARAS K.
6. Tyagi N, Qipshidze N, Givvimani S, Kandel M, MISHRA PK, Sen U, Johar A, Tyagi SC.
Tetrahydrocurcumin ameliorates mtMMP-9 mediated mitophagy and mitochondria
remodeling in Stroke. FASEB J, 24: 604.4; 2010.
7. Basu P, Qipshidze N, Sen U, MISHRA PK, Tyagi S. Blood flow regulates vasculature by
maintaining elastin /collagen and MMP/ TIMP ratio. FASEB J, 24: 790.3; 2010.
8. Munjal C, Falcon JF, Qipshidze N, MISHRA PK, Tyagi SC. DDAH-2 & eNOS in Mesenteric
Vascular Remodeling : Role of Fenugreek. FASEB J, 24: 774.7; 2010.
9. Kandel M, Tyagi N, Qisphidze N, Munjal C, Basu P, Givvimani S, Abe O, MISHRA PK, Sen U,
Tyagi SC. Folic acid mitigated homocysteine-mediated decrease in bone blood flow and bone
remodeling. FASEB J, 24: 630.7; 2010.
10. Givvimani S, Jala R, MISHRA PK, Sen U, Tyagi N, Qipshidze N, Munjal C, Tyagi SC. Functional
heterogeneity in vascular remodeling (MMP-9-/- and PAR-1-/+) in hyperhomocysteinemic (CBS/+) and diabetic (Akita, Ins2-/+) mice. FASEB J, 24: 599.6; 2010.
11. MISHRA PK, Givvimani S, Sen U, Abe OA, Tyagi N, Basu P, Munjal C, Tyagi SC. Role of dicer in
diabetic cardiomyopathy through dysregulation of MMP-9 and TIMP-4. FASEB J, 24: 978.19;
2010.
12. Tyagi N, Qipshidze N, Munjal C, Metreveli N. Dankowski A, MISHRA PK, Sen U, Lominadze D,
Givvimani S, Tyagi SC. Hydrogen Sulfide ameliorates mitochondrial MMP-9 mediated
mitochondria remodeling in cerebral ischemia. FASEB J, 25: 650.7; 2011.
13. Givvimani S, Sen U, Tyagi N, MISHRA PK, Munjal C, Qipshidze N, Metreveli N, Tyagi SC.TIMP2 mutant decreases MMP-2 activity and augments pressure overload induced left ventricular
dysfunction and heart failure. Hypertension, 58:e33-e83; 2011.
14. Sen U, Qipshidze N, Givvimani S, MISHRA PK, Munjal C, Tyagi N, Tyagi SC. Hydrogen sulfide
mitigates homocysteine-mediated mitophagy. FASEB J, 25: 643.25; 2011.
15. Munjal C, Tyagi N, Qipshidze N, MISHRA PK, Givvimani S, Sen U, Lominadze D, Tyagi SC. The
siRNA targeting MMP-9 mitigates Homocysteine induced disruption of barrier integrity in Human
intestinal microvascular cells. FASEB J, 25: 1066.7; 2011.
16. Qipshidze N, MISHRA PK, Metreveli N, Lominadze D, Tyagi SC. Hydrogen sulfide improves
angiogenesis and regulates cardiac function and structure during myocardial infarction in mice.
FASEB J, 25: 1092.10; 2011.
17. MISHRA PK ,Awe O, Metreveli N, Qipshidze N, Munjal C, Tyagi N, Tyagi SC. Exercise
ameliorates diabetic cardiomyopathy by inducing beta2-adrenergic receptors and miR-133a, and
attenuating MMP-9. FASEB J, 25: 1032.4; 2011.
18. Qipshidze N, Munjal C, Tyagi N, MISHRA PK, Sen U, Givvimani S, Metreveli N, Lominadze D,
Tyagi SC, Mechanism of right ventricular remodeling in mouse model of pulmonary hypertension.
Hypertension, 58:e33-e83; 2011.
19. Tyagi N, Qipshidze N, Munjal C, Metreveli N, MISHRA PK, Sen U, Givvimani S, Lominadze D,
Tyagi SC. H2S ameliorates oxidative stress and protects the brain against cerebro-vascular
remodeling in ischemia/reperfusion injury. Hypertension, 58:e33-e83; 2011.
20. MISHRA PK, Metreveli N, Tian Q, Qipshidze N, Tyagi N, Sen U, Givvimani S, Joshua I G, Liu C,
Tyagi SC. MiR-133 ameliorates MMP9 induced diabetic cardiomyopathy. Hypertension, 58:e33e83; 2011.
21. MISHRA PK, Metreveli N, Chavali V, Tyagi N, Qipshidze N, Sen U, Joshua I G, Tyagi SC. Role
of MMP9 in cardiac stem cell differentiation and autophagy. FASEB J, 26: 1060.10, 2012.
16
April 2016
MISHRA, PARAS K.
22. Tyagi N, Narayanan N, MISHRA PK, Qipshidze N, Givvimani S, Tyagi SC, Epigenetic
reprogramming of mitochondrial dysfunction in hyperhomocysteinemia. FASEB J, 26: 701.17,
2012.
23. Tyagi N, Qipshidze N, Givvimani S, MISHRA PK, Lominadze D, Tyagi SC. Homocysteine induces
alteration of tight junction proteins in brain endothelial cells. Stroke, 43: A3754, 2012.
24. MISHRA PK, Chavali V, Sathnur P, Qipshidze N, Tyagi SC. H2S ameliorates homocysteine
mediated attenuation of miR-133 and β2-AR in diabetic hearts. Nitric Oxide, 27: S38, 2012.
25. Qipshidze N, MISHRA PK, Givvimani S, Sen U, Tyagi SC. Hydrogen sulfide protects coronary
vasospasm after myocardial infarction and eliminates myocardial infarction zone by promoting to
grow new vessels. Nitric Oxide, 27: S32, 2012.
26. MISHRA PK, Joshua IG, Tyagi SC. Exercise mitigates beta-2 adrenergic receptor dysfunction by
decreasing homocysteine in diabetes. FASEB J, 26: 1076.2, 2012.
27. Chavali V, Tyagi N, Tyagi SC, MISHRA PK. MiR-133 as an epigenetic regulator of diabetic heart
failure. FASEB J, 26: 1057.22, 2012.
28. MISHRA PK, Chavali V, Metreveli N, Tyagi SC. Targeted deletion of MMP9 mitigates autophagy
mediated contractile dysfunction in Insulin 2 mutant diabetic mice. Circulation, 126: A19387, 2012.
29. Chavali V, Diaz, N L, Tyagi SC, MISHRA PK. MiR-133a ameliorates cardiac stem cells survival
and differentiation in Insulin2 mutant diabetic mice. FASEB J, 27: 1151.2, 2013.
30. Chavali V, Harris JM, Givvimani S, Qipshidze N, Murphy LA, Tyagi G, Metreveli N, Tyagi SC,
MISHRA PK. Exercise ameliorates high fat diet mediated inflammation, DNA methylation and
heart failure in female mice. FASEB J, 27: 1134.6, 2013.
31. MISHRA PK, Chavali V, Metreveli N, Tyagi SC. Ablation of MMP9 ameliorates epigenetic
modifications and mitigates diabetic cardiomyopathy. FASEB J, 27: 1129.3, 2013.
32. Qipshidze N, MISHRA PK, Tyagi SC. Mitochondrial division inhibitor (Mdivi-1) ameliorates post
myocardial infarction via stimulating stem cell by elevating level of miR-499 in diabetes. FASEB
J, 27: 1151.1, 2013.
33. MISHRA PK. Abrogation of MMP9 ameliorates cardiac dysfunction in diabetes. J Clin Expt.
Cardiology, 4: 82, 2013.
34. Nandi S, Liu X, Sharma N, Chavali V, Patel K, MISHRA PK. miR-133a ameliorates cardiac
dysfunction in diabetes: possibly by restoring beta-adrenergic receptor function and expression.
FASEB J, 28: 1078.6, 2014.
35. Nandi S, MISHRA PK. MiR-133a alleviates cardiac autophagy by targeting AMPK in Ins2+/diabetic mice. FASEB J, 28: 868.3, 2014.
36. MISHRA PK, Nandi S, Chavali V. Mdivi-1 mitigates cardiac dysfunction by attenuating mitophagy
in diabetes. FASEB J, 28: 1155.3, 2014.
37. Wang H, MISHRA PK, Nandi SS, Cornish KG, Zucker IH. Cardiac sympathetic afferent
denervation improves cardiac inflammation and ameliorates cardiac remodeling in Post-MI rats.
Hypertension, 64: A487, 2014.
38. Sharma N, Nandi SS, Zheng H, MISHRA PK, Patel KS. Reduced miR-133a results in upregulation
of angiotensinogen in the paraventricular nucleus of rats with chronic heart failure. FASEB J,
29:829.2, 2015.
39. Sharawat S, Nandi SS, Kesherwani V, Shahshahan HR, MISHRA PK. Mdivi-1 mitigates ROS and
mitophagy, improves healthy mitochondrial pool in hyperglycemic cardiomyocytes. FASEB J,
29:1040.4, 2015.
17
April 2016
MISHRA, PARAS K.
40. Nandi SS, MISHRA PK. MiR-133a mitigates mitophagy in Ins2+/- diabetic heart. FASEB J, 29:
1040.1, 2015.
41. MISHRA PK. Novel cardioprotective role of miR-133a. Current Research Cardiology, 2:125, 2015.
42. Nandi SS, MISHRA PK. MiR-133a regulates cardiac autophagy in diabetics. Current Research
Cardiology, 2:121, 2015.
43. Sharma NM, Nandi SS, Liu X, Zheng H, MISHRA PK, Patel KP. Upregulation of angiotensinogen
in the paraventricular nucleus of the hypothalamus during chronic heart failure: Role of miR-133a.
Current Research Cardiology, 2:122, 2015.
44. Hackfort BT, Prathipati P, MISHRA PK. Role of hydrogen sulfide in the regulation of DNA methyl
transferases in cardiomyocytes. Current Research Cardiology, 2:140, 2015.
45. Prathipati P, Hackfort BT, Nandi SS, Shahshahan HR, MISHRA PK. Ablation of MMP9 alleviates
mitophagy and mitigates cardiac dysfunction in diabetics. Current Research Cardiology, 2:144,
2015.
COMMUNITY SERVICE
Volunteer at the University of Louisville hospital, 2010
Blood donation at American Red Cross, 2010.
TEACHING ACTIVITIES
Lecturing
University of Louisville
2010-2012
Physiology 625, Methods in Physiology Research
Topic of Lecture: Flow cytometry (4 lectures, 3 hours each, total 12 hours)
University of Nebraska Medical Center
2013
CIP 916, cardiopulmonary function in health and disease.
Topic of Lecture: Mechanism of cardiac hypertrophy (1lecture, 2 hours)
2014
CIP606/806, Physical Therapy and Physician Assistance and Graduate Students
Topic of Lecture: Sensory systems (10 lectures, 1hour each, total 10 hours)
2015
CIP606/608, Physical Therapy and Physician Assistance and Graduate Students
Topic of Lecture: Sensory systems (10 lectures, 1hour each, total 10 hours)
2015
CIP 807, Graduate Physiology Recitation (1lecture, 1 hour)
2015
CIP 916, cardiopulmonary function in health and disease.
Topic of Lecture: Mechanism of cardiac hypertrophy (1lecture, 2 hours)
18
April 2016
MISHRA, PARAS K.
2015
CIP 916, cardiopulmonary function in health and disease.
Topic of Lecture: MicroRNOmics of heart failure (1lecture, 2 hours)
2015
CIP 916, cardiopulmonary function in health and disease.
Topic of Lecture: Advanced molecular techniques on miRNA assay/autophagy (1lecture,
2 hours)
Coordinator of Course
2015
Advanced level Graduate Course CIP916 entitled “Cardiopulmonary Function in Health and
Disease” with Dr. Irving H. Zucker.
2016 Director of the Department Seminar Program.
2016 Instructor of CIP970 Course.
Research Training
University of Louisville
Mentoring:
Postdoctoral Trainee-
Chavali Vishalakshi, Ph.D.: 2011-2013
M. S. students -
Camille Brunson:
Jessica Harris:
Leiberh Noel Diaz:
2011-2012
2011-2012
2011-2012
Summer students-
Lawrence A. Murphy:
Shreya Barde:
Jennifer Leung:
2012 (B.S.)
2012 (sophomore)
2012 (freshman)
Participated in research training:
(2010-2013)
1.
2.
3.
4.
5.
6.
7.
Natia Qipshidze, MD. (Postdoctoral fellow)
Srikanth Givvimani, MD, Ph.D. (Postdoctoral fellow)
Sourav Kundu, Ph.D. (Postdoctoral Fellow)
Carlo Bartoli (Ph.D. student)
Charu Munjal (Ph.D. student)
Nithyla Narayan (Ph.D. student)
Denise Coley (M.S. student)
19
April 2016
MISHRA, PARAS K.
8. Poulami Basu (Research Assistant)
9. William Gillespie, B.S. (Research Assistant)
10. Jonathan Vacek. B.S. (Summer student)
11. Aaron Tyagi, B.S. (Summer student)
12. Doris Appiah, B.S. (Summer student)
13. Olubusayo Awe, Sophomore (Summer student)
14. Branden Bell, Junior (Summer student)
University of Nebraska Medical Center
Mentoring:
Postdoctoral Trainee1.
2.
3.
4.
5.
6.
Chavali Vishalakshi, Ph.D.
Shyam S. Nandi, Ph.D.
Surender K. Sharawat, Ph.D.
Varun Kesherwani, Ph.D.
Bryan T Hackfort, Ph.D.
Priyanka Prathipati, Ph.D.
2013
20132014-2015
2014-2015
20152015-
1.
2.
3.
4.
5.
Shamma S. Rahman
Denise A. Cobb
Paul Sarjo
Anyun Ma
Ahmed M Wafi
2013
2014
2015
2015
2016
Ph.D. Rotating students-
APRDP Summer Research Program (UNMC and China collaborative program)
1. Yiwen Xia, M.D. student
2014
Summer students-
Participated in Training-
1. Pranay Velichery:
2. Santosh Ramini:
3. Vikas Mudgapalli:
2013 (Junior)
2014 (Sophomore)
2014 (Junior)
1. Dr. Anusha Ammu (M.B.B.S.)
2015
Seminars/ grand rounds for graduate student, fellows and faculties
1. MicroRNA and MMP9 in the diabetic heart. Department of Physiology, Wayne State University,
Detroit, Michigan (November 8, 2012)
2. MicroRNA and MMP9 in the diabetic heart. Cleveland Clinic learner Research Institute, Cleveland,
Ohio (January 9, 2013)
3. MicroRNA and MMP9 in the diabetic heart. Department of Cellular and Integrative Physiology,
University of Nebraska Medical Center, Omaha, Nebraska (January 22, 2013)
20
April 2016
MISHRA, PARAS K.
4. Role of MMP9 in diabetic cardiomyopathy. Institute of Cellular Therapeutic, University of Louisville,
Louisville, Kentucky (January 29, 2013)
5. Multifaceted role of miR-133 in the heart. Department of surgery, University of Nebraska Medical
Center, Omaha, Nebraska (September 11, 2013)
6. Novel regulatory mechanisms of diabetic cardiomyopathy. Department of Internal Medicine,
University of Nebraska Medical Center, Omaha, Nebraska (January 31, 2014)
7. Role of miRNA in cardiac remodeling. M.D. / Ph.D. Scholar Program Luncheon meeting, University
of Nebraska Medical Center, Omaha, Nebraska (April 3, 2014)
8. Mechanism of pathological cardiac remodeling in diabetics. Department of Pharmacology,
University of Nebraska Medical Center, Omaha, Nebraska (April 18, 2014)
9. Regulating the regulators of autophagy in diabetic hearts. The Nebraska Gateway to
Nutrigenomics Seminar Series, University of Nebraska Lincoln, Lincoln, Nebraska (October 8,
2014)
10. Autophagy and miRNA in diabetic heart failure. Cardiology Grand Round. Division of Cardiology,
School of Medicine, UNMC, Omaha, Nebraska (February 25, 2015)
Selected poster presentations at UNMC
1. Nandi SS, MISHRA PK (2015). MiR-133a regulates cardiac autophagy in diabetics. Annual meeting
of the international academy of cardiovascular sciences (IACS): North American Section” held in
Omaha from September 10-12 (Received the Morris Karmazyn Award for Best Poster in
Translational Medicine).
2. Sharma NM, Nandi SS, Liu X, Zheng H, MISHRA PK, Patel KP (2015). Upregulation of
angiotensinogen in the paraventricular nucleus of the hypothalamus during chronic heart failure:
Role of miR-133a. Annual meeting of the international academy of cardiovascular sciences (IACS):
North American Section” held in Omaha from September 10-12 (Received the Eric Olson Young
Faculty Award).
3. Hackfort BT, Prathipati P, MISHRA PK (2015). Role of hydrogen sulfide in the regulation of DNA
methyl transferases in cardiomyocytes. Nebraska Physiological Society meeting, held in University
of South Dakota on October 10 (Received the Best Poster Presentation Award).
4. Prathipati P, Hackfort BT, Nandi SS, Shahshahan HR, MISHRA PK. Ablation of MMP9 alleviates
mitophagy and mitigates cardiac dysfunction in diabetics. Nebraska Physiological Society meeting,
held in University of South Dakota on October 10 (Received the Oral Presentation Award).
5. MISHRA PK (2015). Novel cardioprotective role of miR-133a. Annual meeting of the international
academy of cardiovascular sciences (IACS): North American Section” held in Omaha from
September 10-12.
6. Nandi SS, MISHRA PK (2015). MiR-133a mitigates mitophagy in Ins2+/- diabetic heart.
Experimental Biology, March 28- April1, Boston, USA (Selected for Oral presentation).
7. Wang Hanjun, MISHRA PK, Nandi SS, Cornish KG, Zucker IH (2014). Cardiac sympathetic
denervation improves cardiac inflammation and ameliorates cardiac remodeling in post -MI
rats. AHA, High Blood Pressure Research, September 9-12, San Francisco, USA.
21
April 2016
MISHRA, PARAS K.
8. Nandi SS, Chavali V, MISHRA PK (2014). MiR-133a alleviates cardiac autophagy by targeting
AMPK in Ins2+/- diabetic mice. Experimental Biology, April 26-30, San Diego, USA (Selected for
Oral presentation).
9. Nandi SS, Liu X, Zheng H, Sharma H, Chavali V, Patel KS, MISHRA PK (2014). MiR-133a
ameliorates cardiac dysfunction in diabetes: possibly by restoring β-adrenergic receptor function
and expression. Experimental Biology, April 26-30, San Diego, USA (Selected for Oral
presentation).
10. MISHRA PK, Nandi SS, Chavali V (2014). Mdivi-1 mitigates cardiac dysfunction by attenuating
mitophagy in diabetes. Experimental Biology, April 26-30, San Diego, USA.
11. Chavali V, Nandi SS, MISHRA PK (2013). Mitochondrial division inhibitor (Mdivi-1) ameliorates
diabetic cardiomyopathy by attenuating mitophagy and DNA methylation. Nebraska Physiological
Society Meeting, October 4, University of Nebraska, Omaha, NE, USA.
12. Nandi SS, Chavali V, MISHRA PK (2013). MiR-133a mitigates autophagy by regulating
AMPK/mTOR signaling and ameliorates diabetic cardiomyopathy. Nebraska Physiological Society
Meeting, October 4, University of Nebraska, Omaha, NE, USA.
13. Chavali V, Metreveli N, Tyagi S, MISHRA PK (2013). Mitochondrial division inhibitor (Mdivi-1)
mitigates autophagy and DNA methylation, and ameliorates diabetic cardiomyopathy. The
cardiovascular Forum for Promoting Centers of Excellence and Young Investigators, August
15-17, Louisville, Kentucky, USA. (Selected for James Willerson Clinical Award Lecture).
Selected first and last author poster presentations
14. MISHRA PK, Chavali V, Metreveli N, Tyagi SC (2013). Ablation of MMP9 ameliorates epigenetic
modifications and mitigates diabetic cardiomyopathy. Experimental Biology, April 20-24, Boston,
USA.
15. Chavali V, Diaz NL, Tyagi SC, MISHRA PK (2013). MiR-133a ameliorates cardiac stem cell
survival and differentiation in Insulin 2 mutant diabetic mice. Experimental Biology, April 20-24,
Boston, USA.
16. Chavali V, Harris J M, Givvimani S, Qipshidze N, Murphy LA, Tyagi G, Metreveli N, Tyagi SC,
MISHRA PK (2013). Exercise ameliorates high fat diet mediated inflammation, DNA methylation
and heart failure in female mice. Experimental Biology, April 20-24, Boston, USA.
17. MISHRA PK, Chavali V, Metreveli N, Tyagi SC (2012). Targeted deletion of MMP9 mitigates
autophagy mediated contractile dysfunction in Insulin 2 mutant diabetic mice. AHA, Scientific
Session, November 3-7, Los Angeles, USA.
18. MISHRA PK, Metreveli N, Chavali V, Tyagi N, Qipshidze N, Sen U, Joshua IG, Tyagi SC. (2012).
Role of MMP9 in cardiac stem cell differentiation and autophagy. Experimental Biology, April
21-25, San Diego, California, USA.
19. Chavali V, Tyagi N, Tyagi SC, MISHRA PK. (2012). MiR-133 as an epigenetic regulator of
diabetic heart failure. Experimental Biology, April 21-25, San Diego, California, USA.
20. MISHRA PK, Chavali V, Sathur P, Qipshidze N, Tyagi SC (2012). H2S ameliorates
homocysteine mediated attenuation of miR-133 and β2-AR in diabetic hearts. 2nd International
Conference on H2S Biology and Medicine, September 20-22, Atlanta, Georgia, USA. Selected
for Best Poster Award.
22
April 2016
MISHRA, PARAS K.
21. MISHRA PK, Chavali V, Metreveli N, Tyagi SC (2012). Targeted deletion of MMP9 mitigates
autophagy mediated contractile dysfunction in Insulin2 mutant diabetic mice. Scientific Session,
American heart Association, November 3-7, Los Angel, CA, USA.
22. MISHRA PK, Joshua IG, Tyagi SC. (2012). Exercise mitigates beta2-adrenergic receptor
dysfunction by decreasing homocysteine in diabetes. Experimental Biology, April 21-25, San
Diego, California, USA.
23. MISHRA PK, Awe O, Metreveli N, Qipshidze N, Munjal C, Tyagi N, Tyagi SC. (2011). Exercise
ameliorates diabetic cardiomyopathy by inducing beta2-adrenergic receptors and miR-133a,
and attenuating MMP-9. Experimental Biology, April 9-13, Washington DC, USA.
24. MISHRA PK, Metreveli N, Givvimani S, Panguluri SK, Sen U, Tyagi N, Basu P, Munjal C, Joshua
IG, Tyagi SC. (2010). Ablation of MMP-9 ameliorates miR-1 and -133 mediated cardiac
dysfunction in insulin2 mutant diabetic mice. Best of AHA specialty conference. (Best of HBPR
2010). Scientific session of AHA, Chicago, USA.
25. MISHRA PK, Givvimani S, Sen U, Abe OA, Tyagi N, Basu P, Munjal C, Tyagi SC. (2010). Role
of dicer in diabetic cardiomyopathy through dysregulation of MMP-9 and TIMP-4. Experimental
Biology, April 24-28, Anaheim, California, USA.
26. MISHRA PK, Metreveli N, Givvimani S, Kundu S, Tyagi N, Qipshdze N, Sen U, Basu P, Abe
OA, Gillespie WM, Munjal C, Vacek J, Tyagi SC (2009). Down regulation of dicer involved in
MMP-9 mediated cardiomyocytes dysfunction. 63rd High Blood Pressure Research Conference,
Chicago, USA.
27. MISHRA PK Tyagi N, Kumar M, Kumar M, Kundu S, Givvimani S, Sen U, Tyagi SC (2009). Role
of microRNAs in homocysteine-induced oxidative stress. Experimental Biology, April 18-22. New
Orleans, LA. USA.
23