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Hereditary Cancer Testing GENE LIST Panel: Renal19 CDC73 MET MSH6 SDHB TSC1 EPCAM MITF PMS2 SDHC TSC2 FH MLH1 PTEN SDHD VHL FLCN MSH2 SDHA TP53 Renal cancer is relatively common, and about 3-8% of renal cancer is hereditary.1 Renal19 is a genetic test that looks for changes in 19 genes associated with a hereditary risk of renal cancer.5-16 GENE SYNDROME Hyperparathyroidism jaw tumor syndrome ASSOCIATED CANCERS AND FINDINGS CDC73 FH Hereditary leiomyomatosis and renal cell cancer kidney, uterine fibroids, skin findings FLCN Birt-Hogg-Dubé syndrome kidney, lung cysts, skin findings MET Hereditary papillary renal carcinoma kidney parathyroid carcinoma, renal cysts and hamartomas, Wilms tumor kidney, melanoma MITF MLH1, MSH2, MSH6, PMS2, EPCAM Lynch syndrome colon, uterine, ovary, stomach, renal pelvis, and others PTEN Cowden syndrome (PTEN-hamartoma tumor syndrome) Hereditary paraganglioma-pheochromocytoma breast, thyroid, endometrial, kidney, and others TP53 Li-Fraumeni syndrome breast, sarcoma, brain, adrenocortical, and others TSC1, TSC2 VHL Tuberous sclerosis complex kidney, benign or malignant angiomyolipoma, oncocytoma, and others von Hippel-Lindau syndrome kidney, hemangioblastomas of (multiple organs), pheochromocytoma, central nervous system tumors SDHA, SDHB, SDHC, SDHD paraganglioma, pheochromocytoma, kidney, GIST References available on the Human Genetics Laboratory website: www.unmc.edu/mmi/geneticslab/resources/reference-articles.html UNMC Human Genetics Laboratory where excellence is dominant | 402-559-5070 | www.unmc.edu/geneticslab
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