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Hereditary Cancer Testing GENE LIST Panel: Colorectal20 APC BMPR1A EPCAM MLH1 MUTYH POLE STK11 ATM CDH1 GALNT12 MSH2 PMS2 PTEN TP53 AXIN2 CHEK2 GREM1 MSH6 POLD1 SMAD4 Approximately 5-10% of colorectal cancers are hereditary, and the majority are caused by a set of high-risk genes.1-3 Colorectal20 is a genetic test that looks for changes in 20 genes known to moderately or highly increase the risk for colorectal cancer.4-20 Hereditary Causes of Colorectal Cancer unknown genes Lynch syndrome Genes associated with an increased risk for colorectal cancer in the setting of few or no polyps MLH1, MSH2, MSH6, PMS2, EPCAM Polyposis syndromes Genes associated with an increased risk for numerous polyps and colorectal cancer APC, MUTYH, BMPR1A, SMAD4, PTEN, STK11 Rare Genes with undefined levels of risk for colorectal cancer and/or polyps ATM, AXIN2, CDH1, CHEK2, GALNT12, GREM1, POLD1, POLE, TP53 Sporadic (non-hereditary) Causes: Environment, Familial Risk Factors, and Chance References available on the Human Genetics Laboratory website: www.unmc.edu/mmi/geneticslab/resources/reference-articles.html UNMC Human Genetics Laboratory where excellence is dominant | 402-559-5070 | www.unmc.edu/geneticslab
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