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Neuro Objectives 19 1. Note: Clarke’s nucleus takes leg mechanoreceptors into the spinocerebellar tract Posterior horn: area where sensory afferents synapse Intermediolateral horn: area of sympathetic pre-ganglionic cell bodies (thoracolumbar outflow) Anterior horn: area where motor efferents receive stimuli Posterior funiculi: area where large fibers (touch/position) travel Lateral funiculi: area where corticospinal tract and most of spinothalamic tract travel Anterior funiculi: area where some spinothalamic tract travels Anterior white commisure: area where fibers cross the midline at each spinal cord level Lissauer’s tract: area where small myelinated/unmyelinated (pain/temperature) fibers enter the spinal cord Substantia gelatinosa: area where small myelinated/unmyelinated (pain/temperature) fibers synapse before crossing the midline to join the spinothalamic tract Dorsal rootlet: area where sensory afferents enter the spinal cord Ventral rootlet: area where motor efferents leave the spinal cord 2. Big (lots of white matter) C1 nerve C1 vertebra C2 nerve C2 vertebra C7 nerve C7 vertebra C8 nerve T1 vertebra T1 nerve Conus medullaris (L1, L2) Cauda equina Dural sac (S2) Small (not much white matter) 3. Upper cervical: small anterior horns, large cross-sectional area, lots of white matter, fasciculi gracilis and cuneatus (big) Lower cervical: large anterior horns, large cross-sectional area, lots of white matter, fasciculi gracilis and cuneatus (small) Thoracic: intermediolateral cell column, medium cross-sectional area, medium amount of white matter, fasciculus gracilis only Lumbar/sacral: large anterior horns, small cross-sectional area, small amounts of white matter, fasciculus gracilis only 4. Locations of: a. Alpha motor neurons: anterior horn (big movements) b. Gamma motor neurons: anterior horn (sensitivity of movement) c. Preganglionic sympathetic neurons: thoracolumbar intermediolateral column (sympathetic output) 5. Terminations in the dorsal horn of: a. Small myelinated/unmyelinated: Lissauer’s tract → Substantia gelatinosa → spinothalamic tract → thalamus (VPL) b. Large myelinated: Posterior funiculus → posterior column nuclei → medial lemniscus → thalamus (VPL) Note: gracilis – long tracts (i.e. legs); cuneatus – short tracts (i.e. arms) 6. Stretch reflex (one level): Flexor reflex (multiple levels): 7. Arterial blood supply: Note: The anterior spinal arteries join to form one, single anterior spinal artery 8. Touch/position: Ipsilateral 9. Contralateral Pain/temperature: Ipsilateral Contralateral Cortex Cortex Thalamus Thalamus Medial lemniscus Spinothalamic tract Posterior column nuclei Substantia gelatinosa Posterior funiculus Lissauer’s tract Dorsal root Dorsal root Afferent Afferent 10. Voluntary movement: Ipsilateral Contralateral Cortex Internal capsule Cerebral peduncle Basal pons Pyramid Decussation of the pyramids Corticospinal tract Lower motor neuron Ventral root Efferent 11. Fasciculis gracilis: ipsilateral proprioception from lower extremities Fasciculus cuneatus: ipsilateral proprioception from upper extremities Spinothalamic tract: contralateral nociception Corticospinal tract: contralateral upper motor neuron tract 12. Upper motor neuron damage: ventral root/spinal nerve; weakness, areflexia, muscle atrophy Lower motor neuron damage: corticospinal tract; weakness, hyperreflexia, increased tone