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PRESENTED BY: GUIA GAMBOA MYLENE AGUIRRE MARIAN MANASAN JUNE 12, 2008 OCT 24, 2008 Number of deaths for leading causes of death - (USA, 2006) 1. Heart disease: 631,636 2. Cancer: 559,888 3. Stroke (cerebrovascular diseases): 137,119 4. Chronic lower respiratory diseases: 124,583 5. Accidents (unintentional injuries): 121,599 6. Diabetes: 72,449 7. Alzheimer's disease: 72,432 8. Influenza and Pneumonia: 56,326 9. Nephritis, nephrotic syndrome, and nephrosis: 45,344 10. Septicemia: 34,234 DEFINITION OF CANCER ONCOLOGY Oncology is the sum of knowledge regarding tumors; it is the branch of medicine that deals with the study of tumors. Oncology nursing is the care of people with cancer. Until the appearance of AIDS, probably no other medical diagnosis produced as much fear as a diagnosis of cancer. DEFINITION OF CANCER Cancer is a disorder of cellular growth, life span, and death. Is not one disease, but a group of diseases characterized by the uncontrolled growth and spread of abnormal cells. It is a group of abnormal cells that generally proliferate (multiply) more rapidly than do normal cells, lose the ability to perform specialized functions, invade surrounding tissues, and develop growths in other tissues DEFINITION OF CANCER Normal cells have a genetically programmed life cycle that includes a cell death known as apoptosis. Many types of cancer cells lose the ability to die properly as part of their normal life cycle. Statistic Studies The American Cancer Society indicates that in the United States men have a 1 in 2 lifetime risk of developing cancer; for women, the risk is 1 in 3. Of every five deaths in the United States, one is from cancer, making it the second leading cause of death (heart disease is the most common). Statistic Studies Overall, it affects people of all ages, but occurs more frequently in the aged and the very young. An estimated 30% of Americans now living will experience cancer at some point in their lives. The 5-year survival rate is now 62%. Statistic Studies Lung cancer is the leading cause of cancer-related death in both men and women. Other cancers, such as breast and prostate, occur more often than lung cancer, but they have better cure and survival rates due to early detection and treatment. African Americans have a higher incidence of cancer than whites. Asian Americans have the lowest death rate from cancer of any ethnic group. American Indians have a lower incidence of cancer than any other group in the US but have the poorest survival rate when they do get cancer. Carcinogenesis and the Primary Prevention of Cancer Carcinogenesis is the process by which normal cells are transformed into cancer cells. The exact cause of most human cancers is still unknown. The cause and development of each type of cancer are likely to be multiple. It is not known how many tumors have a chemical, environmental, genetic, immunologic, or viral origin. Carcinogenesis and the Primary Prevention of Cancer Carcinogenesis is the term used for the various factors that are possible origins of cancer. Primary prevention of cancer consists of changes in lifestyle habits to eliminate or reduce exposure to carcinogens, substances known to increase the risk for developing cancer. Risk Factors for Cancer Smoking: Smoking is the most preventable cause of death from lung cancer. It is estimated that 87% of people who develop lung cancer are smokers. Dietary habits: Diet plays a role in the development of cancer of the colon, rectum, and breast. A diet high in fiber and low in fat is recommended for prevention. Exposure to radiation: The effects of radiation commonly used for medical diagnosis and treatment are known to be carcinogenic. Excessive exposure to the sun’s ultraviolet rays is a factor in the development of basal and squamous cell skin cancers and melanoma. Risk Factors for Cancer Exposure to environment and chemical carcinogens: There is a greater incidence of bladder cancer among people who live in urban areas and among those who work with dyes, rubber, leather, chlorine and dust from cotton coal, nickel, chromate, asbestos, and vinyl chloride. Smokeless tobacco: increases the risk of cancer of the mouth, larynx, pharynx, and esophagus. Frequent heavy consumption of alcohol: may result in oral cancer and cancer of the larynx, throat, esophagus, and liver. Food to Reduce Cancer Risk Vegetables from the cabbage family, such as: Broccoli Cauliflower Brussels sprout All types of cabbage and kale Vegetables and fruits high in beta - carotene, such as: Carrots Peaches Apricots Squash Broccoli Rich sources of vitamin C, such as: Grapefruit Oranges Cantaloupe Strawberries Red and green peppers Broccoli Tomatoes Food to Reduce Cancer Risk The National Cancer Institute has recommended including at least five servings of fruits and vegetables in the daily diet. Lean meat, fish, skinned poultry Low-fat dairy products, including white cheese rather than yellow Avoid salt-cured, smoked, or nitrite-cured foods Hereditary Cancers Hereditary cancers are those cancers that arise from germline mutations. Hereditary cancers are diagnosed at an earlier age-usually 15 to 20 year earlier than cancers that are not inherited. Often, several relatives have the same or related cancers. Hereditary cancers are characterized by the presence of precursor lesions, such as polyps in colorectal cancer and dysplastic nevi in melanoma. About 90% of cancer are not inherited. Cancer Prevention and Early Detection Prevention and early detection of cancer includes recognition of cancer’s seven warning signals. 1. Change in bowel or bladder habits 2. A sore that does not heal 3. Unusual bleeding or discharge 4. Thickening or lump in breast or elsewhere 5. Indigestion or difficulty in swallowing 6. Obvious change in warts or moles 7. Nagging cough or hoarseness Screening Tests Colorectal tests – beginning at age 50. Prostate cancer detection for men- beginning at age 40 digital rectal examination. Age 50 prostate-specific antigen (PSA) Pelvic examination with pap smear for women- begin at age 18 or when sexually active. Breast cancer detection (self-exams) – BSE monthly, 2 or 3 days after the menstrual periods ends. After menopause, a woman should choose a specific day to help remind her. Age 40 yearly mammogram Skin examinations: Observe for changes in moles, freckles and other abnormalities Screening Tests Breast Self Examination (BSE): READ on the subject A common reason for delay in diagnosing cancer is that early malignant changes do not produce pain. Cancer may be insidious at the onset, and it may often be far advanced before the individual experiences any symptoms. PATHOPHYSIOLOGY OF CANCER Cell Mechanisms and Growth The basic unit of structure and function in all living things is the cell. Approximately 60,000 billion cells are in the adult human body and, although there are many different types of cells, all of them have certain common characteristics. PATHOPHYSIOLOGY OF CANCER Cell Mechanisms and Growth Most cells have the ability to reproduce. Whenever cells are destroyed, the remaining cells of the same type reproduce until the correct number have been replenished. This orderly replacement of cells is governed by a control mechanism that stops when the loss or damage has been corrected. The healthy cell is a small duplicating machine, perfectly copying itself over and over. Pathophysiology of Cancer Cancer cells are not subject to the usual restrictions placed on cell proliferation by the host. When malignant cells change, they become unlike parent cells. They are not differentiated or recognizable as being the same in size or shapes as normal cells. Pathophysiology of Cancer, cont.. Cancer cells can divide and multiply, but not in a normal manner. Instead of limiting their growth to meet specific needs of the body, they continue to reproduce in a disorderly and unrestricted manner. The cellular features of cancer cells are a local increase in the number of cells, loss of normal cellular arrangement, variation in cell shape and size, increased nuclear size, increased miotic activity, and abnormal mitosis and chromosomes. Pathophysiology of Cancer, cont.. Abnormal cellular growth is classified as: Nonneoplastic growth Neoplastic growth Pathophysiology of Cancer, cont.. Four common nonneoplastic growth patterns Hypertrophy – an increase in size. Hyperplasia - excessive proliferation of normal cells in the normal tissue arrangement of an organ. Metaplasia - conversion of one kind of tissue into a form that is not normal for that tissue. Dysplasia - abnormal development of tissue. Anaplasia – “without form”, an irreversible change in which the structures of adult cells Neoplasm is the term for uncontrolled or abnormal growth of cells. Neoplasm may be benign ( not recurrent or progressive; nonmalignant ) or malignant (growing worse and resisting treatment, as in cancerous growths). The growth are also called tumors, which means swelling or enlargement. They may be localized or invasive. Benign tumors may become serious because of localized increase in growth with damage to surrounding tissues, as in benign brain tumor. Malignant neoplasms may progress and destroy surrounding tissues. They may also metastasize from the primary site of origin to distant sites. Pathophysiology of Cancer Metastasis is the term used to describe the movement of cancer cells from the primary site to a secondary site. the process by which tumor cells are spread to distant parts of the body. Pathophysiology of Cancer Metastasis can occur by the following mechanisms: Direct spread of tumor cells by diffusion to other body cavities. Circulation by way of blood and lymphatic channels. Transplantation or direct transport of tumor cells from one site to another. Transplantation may occur accidentally during surgery or other procedures when cancer cells are “carried” on The body’s immune system is responsible for recognizing and destroying malignant cells. The immune system may be weakened by cancer-producing substances, tumor cells, and the aging process. Some T cells are responsible for immunosurveillance (the immune system’s recognition and destruction of newly developed abnormal cells). When a cell becomes malignant, it carries a tumor-specific antigen on its membranes that is recognized by the body as nonself and destroyed. If T-cell function is suppressed by age, drugs (corticosteroids), poor nutrition, alcohol, serious infections, or certain disease processes (neoplastic invasion of bone and lymph tissue), the risk of cancer increases. To suppress T-cell rejection of a transplanted organ, steroids and other drugs are administered. The resultant loss of immunosurveillance increases the risk of certain cancers. General Characteristics of Neoplasms Character GROWTH LOCATION Containment BORDERS MOBILITY Resemblance with parent tissues Presence with normal tissues After removal Fatality BENIGN Slow, steady Localized Encapsulated Smooth, well defined Movable Resembles parent tissues MALIGNANT Rate varies, usually rapid Metastasizes Rarely contained Irregular Immobile Little or no resemblance with parent tissues Crowds normal tissues Invades normal tissues Rarely recurs Rarely fatal May recur after removal Fatal with no treatment Description of Tumors Tumors are described according to the parent tissue of the specific location in the body. Carcinoma – originate from the skin or in tissues that line or cover internal organs. Sarcoma – originate from the muscle, bone, fat, or other connective or supportive tissue. Lymphoma and Leukemia – originate from the hematopoietic system. Grading Tumors Tumor grade is a system used to classify cancer cells in terms of how abnormal they look under a microscope and how quickly the tumor is likely to grow and spread. G1 – well-differentiated grade – cells differ slightly from normal cells (mild dysplasia) G2 – moderately well-differentiated grade – cells are more abnormal (moderate dysplasia) G3 – poorly differentiated grade – cells are very abnormal (severe dysplasia) G4 – undifferentiated - cells are immature and primitive (anaplasia) a cell of this origin is difficult to Staging Tumors Clinical Staging Classification System determine the extent of the disease process of cancer. Stage 0: Cancer in situ Stage I: Tumor limited to the tissue of origin; localized tumor growth Stage II: Limited local spread Stage III: Extensive local and regional spread Stage IV: Metastasis TNM Classification System TNM Classification System determine the extent of disease process of cancer according to three parameters. T Tumor size N Degree of regional spread to the lymph nodes M Metastasis TNM Classification System T- Subclasses (Primary Tumor) Tx – tumor cannot be adequately assessed To – no evidence of primary tumor Tis – carcinoma in situ T1, T2, T3, T4 – progressive increase in tumor size and involvement N Subclasses (Regional Lymph Nodes) Nx –regional lymph nodes cannot be assessed No – no regional lymph node metastasis N1, N2, N3, N4 - increasing involvement regional lymph TNM Classification System M Subclasses (Distant Metastasis) Mx – not assessed Mo – no (known) distant metastasis M1, M2, M3, M4 – distant metastasis present, specify site(s) The Papanicolau test, as given by the Bethesda system (the preferred system), are as follows: Negative (normal), formerly class I Probably negative, may indicate infection; atypical squamous cells; reactive change, formerly class II Suspicious, but not conclusive for malignancy; lowgrade squamous intraepithelial lesion, formely class III More suspicious, strongly suggestive of malignancy; high-grade squamous intraepithelial lesion, formerly class IV Conclusive for malignancy; invasive squamous cell carcinoma, formerly class V Diagnosis of Cancer Biopsy Incisional – removal of a portion of tissue for examination. Excisional – removal of the complete lesion, with little or no margin of surrounding normal tissue removed. Needle Aspiration – aspiration of fluid or tissue by means of a needle. Diagnosis of Cancer Endoscopy - Cells or tissue can also be obtained using an endoscope to directly visualize an internal structure through a body cavity or through a small incision. Endoscopes are rigid or flexible tubes containing a magnifying lens and a light. Ex: bronchoscope (tracheobronchial tree); upper gastrointestinal (GI) endoscopy (esophagus, stomach, duodenum); the colonoscopy entire colon; and the sigmoidoscope is used to examine the sigmoid colon, rectum, and anus. Diagnosis of Cancer Diagnostic Imaging Bone Scanning - Indicated to detect metastatic tumors; all malignancies capable of metastasis may reach the bone, especially those malignancies of the breasts, kidneys, lungs prostate, thyroid gland, and urinary bladder. Diagnosis of Cancer Tomography - Tomography is the special technique of making multiple radiographic films at different depths of a specific area, organ, or structure. The details of each thin section can be clearly visualized. Computed Tomography (CT) - Uses radiographs and a computed scanning system to produce and record images of specific structures at different angles. The entire body can be scanned to detect the presence of any abnormal lesion. CT scan is especially helpful to detect small lesions that may not be seen by radiographs or tomography. Diagnosis of Cancer Radioisotope Studies - require the injection or ingestion of a radioactive substance. A scanning device is used to identify the distribution of the substance in different areas of the body. Concentration of the radioisotope in a specific organ, such as the thyroid gland or brain, identifies a tumor in that location (may be primary or metastatic). Diagnosis of Cancer Ultrasound Testing - is a noninvasive procedure using high-frequency sound waves to examine internal structures of the body. An ultrasound beam is directed through the tissues, which reflects back to the transducer. Ultrasound can show the size, consistency, and shape of the structure being studied, and it is most helpful in distinguishing between cystic and solid tumors. Ultrasound is not used to examine bones or air-filled organs. The procedure is painless. Diagnosis of Cancer Magnetic Resonance Imaging (MRI) - This test is currently used in the diagnosis of intracranial and spinal lesions and of cardiovascular and soft tissue abnormalities. The person having MRI must not have any metallic materials on the body during the test; no jewelry may be worn. MRI cannot be done if the person has any metallic implants in the body, such as a pacemaker, orthopedic nail, or aneurysm screw. Laboratory Tests Measurement of Alkaline Phosphatase Blood Level: Elevated if there is metastasis to bone or liver Normal range – 4.5 – 13 U/dL Serum Calcitonin Level Elevated in cancer of the thyroid, breast or lungs Adult female < 25 Adult male <40 Laboratory Tests Carcinoembryonic Antigen (CEA) Serum Level production stops before birth but begins again if a neoplasm develops. Elevated in colorectal CA Used in evaluation of CA treatment in which a rising titer may indicate tumor recurrence Used less because it is also seen in non-CA cases Nonsmokers <2.5 ng/ml smokers <5 ng/ml Laboratory Tests Prostate Specific Antigen (PSA) – Gold standard tumor marker for prostate CA Age 0-39 <2.0 ug/L Age 40 and above 0 - 4 ug/L Cancer Antigen (CA)-125 – ovarian, pancreatic 35 units/mL Stool Examination for Blood – it is essential that the person not have any of the following foods or medications for 4 days before the test: red meat, turnips, melons, aspirin and vitamin c. The test must be performed on To be continued .. Next week and prepare for a quiz Cancer Therapies Surgery The goal of surgery is to remove all malignant cells; this may include the removal of the tumor, surrounding tissue, and regional lymph nodes. Surgery in conjunction with chemotherapy and/or radiation therapy may increase the destruction of cancer cells. Surgery may be performed for many reasons – preventive, diagnostic, curative, and palliative (therapy designed to relieve or reduce intensity or uncomfortable symptoms, but that does not produce a cure). Cancer Therapies Radiation Therapy Radiation therapy can be used to cure or control cancer that has spread to local lymph nodes or to treat tumors that cannot be removed. Radiation may be used preoperatively to reduce the size of a tumor. Postoperative radiation may be indicated to destroy malignant cells not removed by surgery. Radiation may also be used to slow the growth of malignant tumors. Radiation may be delivered externally or internally. Radiation Nursing Intervention for External Radiation A specific area on the body is marked to indicate the port at which external radiation will be directed. These marking must not be washed off. If the are become wet while bathing, the skin should be patted with an absorbent towel. This area need to be protected. Avoid the use of any ointment, lotions, or powder on this area. The physician may approve specific lotions or creams for drying skin. Radiation Nursing Intervention for External Radiation Protect the radiated area from direct sunlight and to avoid applications of heat or cold because these would increase erythema, drying, and pruritus of the skin, which is common over an irradiated area. A diet high in protein and calories and a fluid intake of 2 or 3 quarts per day must be encouraged. Lethargy and fatigue are not uncommon during treatment and that frequent rest periods are helpful. Radiation Nursing Intervention for Internal Radiation Assemble materials and plan ahead to provide several nursing interventions at the same time upon entering the patient’s room. Stand at the greatest distance away from the site where an internal radiation device is in the patient’s body. Stand at least 6 feet away. Limit the time needed for close contact near the irradiated site. Spend no more than 10 minutes at a time. If direct, prolonged care is needed, nurses should wear a lead apron. Children younger than 18 years of age and pregnant women should not be allowed to visit implant patients. Cancer Therapies Chemotherapy Chemotherapy drugs are used to reduce or slow the growth of metastatic caner. Most chemotherapeutic agents work by interfering with a cells’ ability to multiply or reproduce. Drugs that interfere with a cell’s replication (duplicating or reproducing) process damage the cell and cause cellular death. Both malignant and normal cells are affected by chemotherapy. Cells that multiply rapidly are affected the most, such as cells of the hematopoietic system, the hair follicles, and the GI system. Chemotherapy Side Effects of Chemotherapy Hematopoietic System Leukemia – 5000 to 10,000/mm3 Neutropenia – 60% - 70% or 3000 to 7000/mm3 Anemia Thrombocytopenia – 150,000 to 400,000/mm3 Integumentary System Alopecia – loss of hair Gastrointestinal System Stomatitis – inflammation of the mouth Nausea, vomiting , and diarrhea Chemotherapy Nursing Interventions for Chemotherapy Leukopenia/ Neutropenia Monitor for signs of infection. Vital signs every 4 hours. Discourage fresh flowers or live plants in the room. Assess mouth Perform regular, but gentle mouth care. Use soft toothbrush or swab and rinse with normal saline or sodium bicarbonate solution every 2 to 4 hours. Assess skin Rash or eruption which may indicate infection. Use electric razor to shave. Clean skinfolds twice a day with soap and water. Chemotherapy Nursing Interventions for Chemotherapy Assess pulmonary function Encourage deep breathing and coughing exercises. Assess urinary and bowel function Monitor urine output and for possible signs of infection. Monitor stool for color, consistency and presence of blood and change in bowel habits. Anemia Care should be planned to balance activities and rest. Thrombocytopenia Apply direct pressure for 5 to 10 minutes if any bleeding occurs. Avoid contact sports, elective surgery and tooth extraction. Chemotherapy Nursing Interventions for Chemotherapy Avoid picking or blowing nose forcefully. Avoid trauma, falls, bumps, and cuts. Avoid use of aspirin or aspirin preparations. Alopecia Use of gentle shampoo, avoid hair dryers, curling irons , and hair coloring. Wear protective covering. Nausea and vomiting Administer antiemetics before and after therapy. Encourage intake of fluids to prevent dehydration. Chemotherapy Nursing Interventions for Chemotherapy Diarrhea Avoid food that irritate and stimulates peristalsis. Encourage intake of fluids to prevent dehydration. Side Effect of Chemotherapy and Radiation Tumor Lysis Syndrome (TLS) is an oncologic emergency that occurs in cancer patients with heavy tumor burdens after they receive chemotherapy or irradiation , which causes rapid lysis of malignant cells. It may occur anywhere from 24 hrs to 7 days after antineoplatic therapy is initiated. As malignant cells are lysed, intracellular contents are rapidly released into the bloodstream. This results in high level of potassium (hyperkalemia), phosphate (hyperphosphatemia), and uric acid (hyperuricemia), and low level of calcium (hypocalcemia) all put the patient at risk for renal failure and alterations in cardiac function. Medical Management of Tumor Lysis Syndrome Hydration to maintain a urinary output of 150 mL/hr. Hydration should begin 24 to 48 hrs before treatment and continue for at least 72 hrs after treatment. Diuretics may be used to promote the excretion of phosphate, potassium, and uric acid. Diuretics are used to prevent volume overload. Allopurinol prevent uric acid formation. It is begun a few days before treatment and should be continued for 3 to 5 days after treatment is completed. Sodium bicarbonate is used to maintain an alkaline urine (pH>7) to prevent uric acid crystallization. Medical Management of Tumor Lysis Syndrome Cation-exchange resins (Kayexalate) are used to bind with potassium so it can be excreted through the bowel. Calcium gluconate given intravenously is used to correct hypocalcemia. Cardiac monitoring is required. Phosphate-binding gels (aluminum hydroxide) are given to form an insoluble complex that is excreted by the bowel. When these measures are not successful, renal dialysis may be necessary. Successful treatment of TLS depends on preventing renal failure. TLS typically resolves within 7 days, once appropriate treatment is initiated. Cancer Therapies Biotherapy treatment with agents derived from biologic sources or affecting biologic responses. Three major mechanisms of biological response modifiers (BRMs) 1. Increases, restores, or modifies the host defenses against the tumor 2. Toxic to tumor 3. Modifies the tumor biology Most of these therapies are IM or subQ injections and need to be given over an extended time. Cancer Therapies Bone Marrow Transplantation Process of replacing diseased or damaged bone marrow with normally functioning bone marrow. Peripheral Stem Cell Transplantation Alternative to bone marrow transplant This procedure is based on the fact that peripheral or circulating stem cells are capable of repopulating the bone marrow. Advance Cancer Pain Management Patient with cancer may have pain at any point during the course of the disease and its treatment. Pain is almost without exception a late symptom of cancer. Pain control is a major issue in the management of a person with cancer. Pain is whatever the person experiencing the pain says it is, existing whenever the patient says it does. It is of extreme importance not to be judgmental concerning the patient’s complaints of pain. Patients should not be subjected to severe suffering from potentially controllable pain. Fear of addiction should not be a factor when considering pain relief for the terminally ill. Advance Cancer Pain Management The need for around-the-clock dosage is clear. Fixed dosage schedules with adequate doses for pain relief provide more constant blood levels and predictable pain relief. Some patients have breakthrough pain that requires additional doses, but the fixed dosage schedule should be maintained. Patient self control methods include distraction, massage, relaxation, biofeedback, hypnosis, and imagery. Nutritional Therapy Malnutrition High protein , high calorie foods that provide energy and minimize weight loss. Altered Taste Sensation Add spices and other seasoning agents to mask the taste. Lemon juice, onion, mint, basil and fruit juice marinades may improve the taste of certain meats. Bacon bits, onion, and pieces of ham may enhance the taste of vegetables. Neutropenia Fresh fruits and vegetables should be avoided because of the presence of microscopic pathogens in uncooked produce. Nutritional Therapy Nausea and Vomiting Small frequent meals Encourage adequate fluid intake Diarrhea Encourage adequate fluid intake Eliminate spicy foods and high in fat content High protein foods with high caloric value and vitamin and mineral supplements Low residue foods to minimize peristalsis and bowel movement Stomatitis/ Mucositis Soft or liquid diet Anorexia Communication and Psychological Support The patient and family may become irritable and angry with caregivers and nurse when suffering. The nurse must be very understanding towards the patient and family under this circumstances. By listening and administering kind and gentle nursing care, the nurse may communicate more effectively than with words. Touch may also be appropriate, adding the dimension of another human being’s awareness of the emotional distress being experienced. Nurses are in the enviable position of being able to make cancer’s effect less traumatic through sensitivity and creativity. It is important that nurses learn the art of talking to patients, not at patients. A positive attitude of patient, family, and caregivers toward cancer and cancer treatment has a significant positive effect on the quality of life that the patient experiences. Communication and Psychological Support Factors which may determine how the patient copes with the diagnosis of cancer: Ability to cope with stressful events in the past Availability of significant others Ability to express feelings and concerns Age at the time of diagnosis Extent of disease Disruption of body image Presence of symptoms Past experience with cancer Attitude associated with cancer Terminal Prognosis Most patients with advanced cancer know they are dying Honesty and openness are the best approaches Spiritual activities may provide mental and emotional strength Social worker assists the patient and family in planning for home care Hospice services can be arranged-efforts are directed toward relief from pain and other problems THE END References Foundations and Adult Health Nursing- Christensen, Kockrow Basic Pharmacology for Nurses – Clayton, Stock, Harroun American Cancer Society National Cancer Institute