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Acoustic Tweezers: Manipulating Cells using Sound Tony Jun Huang, Ph.D. Professor of Engineering Science and Mechanics The Pennsylvania State University [email protected] http://www.esm.psu.edu/huang/ Acoustic Patterning of Particles/Cells Inlet Outlet IDTs Inlet Outlet IDTs J. Shi, D. Ahmed, X. Mao, S.-C. S. Lin, and T. J. Huang, Lab on a Chip, 2009, 9, 2890-32895. X. Ding, J. Shi, S.-C. S. Lin, S. Yazdi, B. Kiraly, and T. J. Huang, Lab on a Chip, Vol. 12, pp. 2491-2497, 2012. Acoustic Separation of Cancer Cells from Blood Cells SAW on (movie) Cancer cells Cancer cells + Blood cells Blood cells SAW on (stacked image) Cancer cells Cancer cells + Blood cells Blood cells Ding, et al,, Proceedings of the National Academy of Sciences of the United States of America (PNAS), Vol. 111, pp. 12992-12997, 2014 Single Particle Manipulation Using Acoustic Tweezers 100 µm X. Ding, S. Lin, B. Kiraly, H. Yue, S. Li, J. Shi, S. J. Benkovic, and T. J. Huang, Proceedings of the National Academy of Sciences of the United States of America (PNAS), Vol. 109, pp.11105-11109 (2012).