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B
T1D
80
15000
80
ns
hi
% pSTAT5 of CD25
10000
5000
0
60
40
20
0
40
60
p
th
y
e
s
ra
a
hi
D
40
20
10
20
30
40
months on immune therapy
ff
0
SLE
100
Figure S3: Therapy and disease status do not correlate with response to IL-2 in
CD25hi cells of the T1D, MS or SLE cohorts. Data from Figure 1A were analyzed
against clinical parameters for the (A) T1D, (B-C) MS and (D) SLE cohorts. Statistical
significance was determined using linear regression in (A, C) and a Mann Whitney test
in (B). The mean pSTAT5 response is indicated for each group in (B, D).
IL2RArs2104286 genotype is noted by solid black (A/A), solid grey (A/G) and open
(G/G) symbols where measured in the T1D and MS cohorts.
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% pSTAT5 of CD25
60
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% pSTAT5 of CD25
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R = 0 .0 0 0 0 1
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MS
% pSTAT5 of CD25hi
A
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