Download The Immune System

The Immune
System
memory and
specificity
Chapter 43
http://www.cellsalive.com/antibody.htm
http://inet.uni2.dk/~iirrh/IIRhome.htm
Topics in Immunity
• Allergies:
--plasma cells, immunoglobulins,
and mast cells
--antibodies and antigens
• HIV-AIDS
-- infection of T cells
-- place of T cells in the immune
system
• distinguishing self from non-self
One of the culprits: ragweed pollen
© Dennis Kunkel
Figure 42.14x Blood smear
Figures 42.15 & 16 Types and Differentiation of blood cells
Figure 43.8a,b The structure of a typical antibody molecule
Table 43.1 The Five Classes of Immunoglobulins
Figure 43.16 Effector mechanisms of humoral immunity
Figure 43.12 Clonal selection of B cells
Timing of primary and secondary immune
response
pollen (the allergen)
stimulates histamine release
from mast cells
Figure 43.18 Mast cells, IgE, and the allergic response
Figure 43.14 An overview of the acquired immune responses 2
Topics in Immunity
• Allergies:
--plasma cells, immunoglobulins,
and mast cells
--antibodies and antigens
• HIV-AIDS
-- infection of T cells
-- place of T cells in the immune
system
• distinguishing self from non-self
Figure 42.14x Blood smear
Figures 42.15 & 16 Types and Differentiation of blood cells
Figure 43.9 The interaction of T cells with MHC molecules
Structure and positioning of the Major histocompatibility complex (MHC) proteins
Class I
Class II
Interaction of an MHC protein with its antigen
Class I
Cytotoxic T cell action (FIG. 43.16)
Clonal selection of Helper T cells and Cytotoxic T cells (FIG.
43.15)
Figure 43.14 An overview of the acquired immune responses 1
Figure 43.14 An overview of the acquired immune responses 2
Figure 43.14 An overview of the acquired immune responses 2
Figure 43.14 An overview of the acquired immune responses 3
Presenting antigens: CD4 helps stabilize the
connection.
(usually a macrophage)
Figure 43.19 A T cell infected with HIV
Figure 43.19x1 HIV on a lymphocyte, detail
Figure 18.7 HIV, a retrovirus
Figure 43.19x2 HIV budding
Figure 43.20 The stages of HIV infection
Only cells with both CD4
proteins and chemokine receptor
proteins (CXCR4, CCR5) are
vulnerable to the HIV virus.
These are the central cells in the
immune system.
Figure 43.14 An overview of the acquired immune responses 3
Figure 43.14 Epitopes (antigenic determinants)
Topics in Immunity
• Allergies:
--plasma cells, immunoglobulins,
and mast cells
--antibodies and antigens
• HIV-AIDS
-- infection of T cells
-- place of T cells in the immune
system
• distinguishing self from non-self