Download Functions of Immune System

Hello , Everyone !
Medical Immunology
Li Yi
医学免疫学
(李一)
Professor, Director of Ph D 教授、博士生导师
Department of Immunology 免疫学教研室
[email protected]
我们可以为了从高处鸟瞰风景的缘故而去爬一
棵树，也可以由于有一头野兽在后面紧紧追赶的缘
故而去爬一棵树。
前者: 我们爬树是为了娱乐
我们要不要爬树完全是我们的自由
我们可以寻找一棵最适合我们意图的树.
后者: 我们则是受恐惧的驱使
我们喜不喜欢都得这样做
我们必须立刻就近爬上树去
也就是说由一头野兽替我们作出了选择 .
摘自:史铁生散文“对话四则 ”
Today
 Study of immunology**
 Overview of immunology***
Study of immunology**
Books:
English / Chinese
Classes:
Theory (32hours)
Experiment (28hours)
Examinations:
Theory: During class (10’)
Final (70’)
Experiment: During class (20’)
“过渡式双语教学”模式
Introduction
Components
of IS
Pathology of IR
Functions of IS
Applications
考试方式

闭卷“考试”与开卷“综述”相结合
 闭卷“考试”中采用英文必答、中英文选答相结合。
IMMUNOLOGY
???
Let’s start with
questions
Question-1
Our environment contains a great variety
of infectious microbes, why could we keep
healthy?
Question-2
What should we do before
transplanting blood ---Transfusion ?
Questions - 3
1.
Why do we need to do gene matching before
transplantation ?
2.
Why is it very difficult to find perfect donor for
recipient in transplantation ?
Question-4

Do you have any experience
about allergy?

What is the allergy?
Question-5
1. What is vaccine ?
2. How do vaccines work?
Questions？
Immunology
Answer！
Immunology
Functions
of IS
Immune
System
Pathology
of IS
Applications
Functions of Immune System
• Immunological defense
• Immunological homeostasis
• Immunological surveillance
Functions of Immune System -1
• Immunological defense:
The immune system protects us from
attack by microbes and worms.
Functions of Immune System -2
Immunological
homeostasis :
The immune system
could eliminate the
inflammatory or died
self-cells.
Functions of Immune System -3
Immunological surveillance:
The immune system could destroy the
tumor cells and protects us from clinical
tumor formation.
Tumor
cell
Tumor
Tumor
Tumor
cell
cell cell Tumor
Tumor
Tumor cell
cell
cell
Overview of Immunology
Components
of IS
Organs and tissues
Functions
of IS
Antigen (Ag)
Pathology
of IR
Hypersensitivity
Applications
Prevention
Autoimmune disease
Cells
Immune Responses
Immunodeficiency
Tumor
Molecules
Control mechanisms
Transplantation
rejection
* IS: Immune system
IR: Immune response
Diagnosis
Therapy
Immune Responses



Immunologic defense
Immunologic homeostasis
Immunologic surveillance
Organs and tissues
Ag
IR
Cells
Molecules





Hypersensitivity
Immunodeficiency
Autoimmune diseases
Tumor
Transplantation rejection
Components of immune system
 Organs and tissues
 Cells
 Molecules
Components of IS -1
Organs and Tissues of Immune System
— Primary lymphoid organs
• Bone Marrow
• Thymus
— Secondary lymphoid organs
• Lymph nodes
• Spleen
• Mucosa-associated lymphoid tissues (MALT)
Components of IS -2
Cells of Immune System
—
—
—
Mononuclear phagocyte system
Granulocytes
Lymphocytes
Neutrophils
Basophils
Eosinophils
T lymphocyte
B lymphocyte
NK (Natural killer cells)
Monocyte
Macrophage
Dendritic Cells
Classes of T cells
TH: T help cells
TH1
TH2
TC: T cytotoxic cells, CTL
Cells of Immune System
Phagocytes:
Cells of mononuclear phagocyte system
Neutrophils (Polymorphonuclear neutrophils, PMN)
Auxiliary cells
Basophiles (mast cells)
Cytotoxic cells
Tc (CTLs)
NK cells
Eosinophils
Components of IS -3
Molecules of Immune System
— Antibody (Ab)
— Complement (C)
— Cytokines (CK)
— Major Histocompatibility Complex (MHC)
Overview of Immunology
Components
of IS
Organs and tissues
Functions
of IS
Antigen (Ag)
Pathology
of IR
Hypersensitivity
Applications
Prevention
Autoimmune disease
Cells
Immune Responses
Immunodeficiency
Tumor
Molecules
Control mechanisms
Transplantation
rejection
* IS: Immune system
IR: Immune response
Diagnosis
Therapy
Functions of Immune System
Antigen (Ag)
Immune Responses (IR)
Control mechanisms
See:
Immune Response (IR)
Target
cells
MHC
CK
Th1
CKs
Tc
NK
Ag
DCs
MHC
CK
Th2
CKs
Ab
B
PMN
Complement
Types of Immune Response
 Innate immunity (Natural immunity)
 Adaptive immunity (Acquired immunity)
Innate and Adaptive Immunity
Innate immunity
Adaptive immunity
Cells
Mq/DCs
Granulocytes
NK cells
T and B cells
Molecules
Cytokines
Complement
Antibodies
Characteristics
Responds rapidly
No specificity
No memory
Slow to start
Highly specificity
Memory
Innate immune response
( Natural Immunity)
— External defenses
— Cell effects
— Molecular effects
PAMP: pathogen-associated
molecule pattern
Mq/DCs
PRR
Phagocytosis
Recognition and killing of phagocytes
By pattern recognition receptors(PRR)

Mannose receptors: mannose

CD14 : LPS

Scavenger receptors : carbohydrates /lipids

Toll like receptors (TLRs): PAMP
(lipid-protein 、LPS、RNA、DNA)
Adaptive Immune Response
(Acquired Immunity)
Three Phases :
Antigen recognition
Activation of cells
Effects
Th-2
Immune Responses



Immunologic defense
Immunologic homeostasis
Immunologic surveillance
Organs and tissues
Ag
IR
Cells
Molecules





Hypersensitivity
Immunodeficiency
Autoimmune diseases
Tumor
Transplantation rejection
Overview of Immunology
Components
of IS
Functions
of IS
Organs and tissues
Cells
Antigen (Ag)
Pathology
of IR

Hypersensitivity

Autoimmune
Molecules
－ Antibodies
－ Complement
－ Cytokines
disease
Immune Responses
Control mechanisms
－ MHC
* IS: Immune system
IR: Immune response

Immunodeficiency

Tumor

Transplantation
rejection
Applications
Prevention
Diagnosis
Therapy
Overview of Immunology
Components
of IS
Functions
of IS
Organs and tissues
Cells
Antigen (Ag)
Pathology
of IR
Hypersensitivity
Applications
Prevention
Autoimmune disease
Molecules
－ Antibodies
Immune Responses
－ Complement
－ Cytokines
Immunodeficiency
Tumor
Control mechanisms
－ MHC
* IS: Immune system
IR: Immune response
Transplantation
rejection
Diagnosis
Therapy
Today
 Study of immunology**
 Overview of immunology***
 Introduction of Dept. immunology*
Reference
Books:
English : P1 – P14
Chinese : P1 – P5