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Transcript
BLOOD TYPING Antigens on the surface of red blood cells help identify “self” Antibodies in the blood bind with foreign cells to stimulate immune response of lymphocytes (white blood cells). This results in “clumping” of the blood. Antigen choices are: A B BLOOD TYPES An A allele tells the red blood cell to put “A” antigens on its surface BLOOD TYPES An B allele tells the red blood cell to put different “B” antigens on its surface BLOOD TYPES An O allele tells the cell NOT to put A or B antigens on its surface A and B are CO-DOMINANT A cell with BOTH an A and a B allele has BOTH “A” and “B” antigens on its surface - What would happen if someone with type B blood got a transfusion of type A blood? - What if that same person got type O? - Type AB? ANTI-A SERUM Adding ANTI-A antibodies to cells with A glycoproteins on their surface causes them to clump together = ________________________ AGGLUTINATION ANTI-A SERUM Adding ANTI-A antibodies to cells with B glycoproteins on their surface causes NO REACTION BLOOD TYPES NO YES Will ANTI-A react? NO YES BLOOD TYPES NO NO Will ANTI-B react? YES YES Blood Typing Example #1 • You mix some of Angelica’s blood with the following serums: – Anti-A serum – Anti-B serum • Angelica’s blood looks clumpy when mixed with Anti-A serum, but not Anti-B. What is her blood type? Blood Typing Example #2 • You mix some of Michael’s blood with the following serums: – Anti-A serum – Anti-B serum • Michael’s blood does not look clumpy with either Anti-A or Anti-B serums. What is his blood type? ABO SYSTEM is NOT THE ONLY ONE + Rh Rh BLOOD TYPES YES Will ANTI-Rh react? NO Questions! • A person who can donate to anyone is known as a “universal donor.” What blood type is this? • A person who can receive blood from anyone is the “universal recipient.” What blood type is this?