Download Introduction/Historical Perspectives 01/17/06

Principles of Immunology
Introduction/
Historical Perspectives
1/17/06
“Everybody can be great, because everybody can serve.”
Martin Luther King, Jr.
 The immune system includes the
tissues, cells and molecules involved in
immunity, both innate and adaptive.
Written exercise
Historical Events in Immunology
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1796-Edward Jenner (smallpox)
1881-Loius Pasteur (vaccines)
1884-Elie Metchnikoff (phagocytes)
1890-Emil von Behring* (antibodies)
1895-Jules Bordet* (complement)
1906-August Wasserman (syphilis)
Historical Events in Immunology
(cont’d)
 1959-Rodney Porter
Gerald Edelman* (antibodies)
 1960-F McFarlane Burnet* (tolerance)
 1975-Cesar Milstein*(monoclonal Ab)
 1987-Susumu Tonegawa* (genetics)
 1996-Peter Doherty
Rolf Zinkernagel* (MHC)
Sub disciplines of Immunology
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Immunobiology
Immunochemistry
Immunopathology
Immunogenetics
Immunodiagnostics
Immunotherapy
Overview of the Immune System
 Innate immunity
 Pre-existing
 Non-specific
 Adaptive immunity
 Responsive
 Specific
Cells of the Immune System
 Phagocytic cells
 Nonspecific
 Specific
 Lymphocytes
 B lymphocytes
 T lymphocytes
 T helper
 T cytotoxic
Two Arms of the
Adaptive Immune System
 Humoral immunity
 Antibodies
 Cell-mediated immunity
 T-cells
Immunological Memory
 More rapid
 More intense
 More prolonged
Chemical Mediators
 Extracellualar
 Cytokines
 Complement
 Intracellular
Antigens and Antibodies
 Antigens
 Chemical makeup
 Types of antigens
 Antibodies
 Chemical makeup
 Roles
 Functions