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CHAPTER 9 Blood and Lymphatic Systems Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Blood System Overview • Blood transports oxygen and nutrients to body cells • Blood removes carbon dioxide and other waste products from body cells for elimination Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Composition of Blood • Plasma – 90 percent water = liquid portion of blood • Transports cellular elements of blood throughout circulatory system – Remaining portion = solutes • Electrolytes, proteins, fats, glucose, bilirubin, and gases • Most abundant solutes are plasma proteins: albumins, globulins, and fibrinogen Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Composition of Blood • Solid components – Formed elements = cells + cell fragments • Erythrocytes, leukocytes, thrombocytes Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Plasma Proteins • Albumins – Constitute about 60 percent of the plasma proteins – Help maintain normal blood volume and blood pressure – Help to maintain balance between fluid in the blood and fluid in the interstitial tissues Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Plasma Proteins • Globulins – Constitute approximately 36 percent of plasma proteins – Alpha and beta globulins transport lipids (fats) and fatsoluble vitamins in blood – Gamma globulins are antibodies and function in immunity Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Plasma Proteins • Fibrinogen – Constitutes approximately 4 percent of plasma proteins – Largest of plasma proteins – Essential in process of blood clotting Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Question True or False: The blood has 2 main components: plasma and proteins. Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Blood Cells • Erythrocytes – Known as red blood cells (RBC) • Tiny biconcave-shaped disks • Thinner in center than around edges • No nucleus in mature red blood cell – Average life span = approximately 120 days – Main component = hemoglobin – Primary function = transport oxygen to cells of body Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Blood Cells • Leukocytes – Known as white blood cells (WBC) • Larger than erythrocytes, but fewer in number • Mature WBC has a nucleus; does not have hemoglobin – Two categories = granulocytes + agranulocytes • Granulocytes have granules in their cytoplasm • Agranulocytes have no granules in their cytoplasm • Five different types of leukocytes within the categories Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Granulocytes • Neutrophils – – – – Constitute approximately 60 to 70 percent of all WBCs Have multi-lobed nuclei Phagocytic in nature Do not absorb acid or base dye well • Remain fairly neutral color Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Granulocytes • Eosinophils – – – – Constitute approximately 2 to 4 percent of all WBCs Have a nucleus with two lobes Increase in number in response to allergic reactions Stain a red, rosy color with an acid dye Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Granulocytes • Basophils – – – – – Constitute less than 1 percent of all WBCs Have a nucleus with two lobes Secrete histamine during allergic reactions Secrete heparin, a natural anticoagulant Stain a dark blue with a base dye Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Agranulocytes • Monocytes – – – – Constitute approximately 3 to 8 percent of all WBCs Largest of all white blood cells Have a kidney bean-shaped nucleus Phagocytic in nature Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Agranulocytes • Lymphocytes – – – – – Constitute approximately 20 to 25 percent of all WBCs Have a large spherical-shaped nucleus Play important role in immune process Some lymphocytes are phagocytic Other lymphocytes produce antibodies Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Cell Fragments • Thrombocytes – Small, disc-shaped fragments of very large cells called megakaryocytes – Also known as platelets – Contain no hemoglobin – Essential for normal clotting of blood Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Question Why would an erythrocyte not have a nucleus? a. It is still an immature cell. b. It needs maximum room to carry oxygen to the body's cells. c. It is a rare mutation but otherwise is present. d. Hemoglobin already has one. Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Blood Types • Blood Type A – Has A-antigen present on RBC – Has Anti-B antibody present in plasma • Blood Type B – Has B-antigen present on RBC – Has Anti-A antibody present in plasma Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Blood Types • Blood Type AB – Has AB-antigens present on RBC – Has no antibodies present in plasma • Blood Type O – Has no antigens present on RBC – Has both Anti-A and Anti-B antibodies present in plasma Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Terms Related to Blood Transfusions • Donor – Person who gives blood • Recipient – Person who receives blood Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Terms Related to Blood Transfusions • Universal donor blood – Type O – No A antigens or B antigens present on its RBCs • Universal recipient blood – Type AB – No Anti-A or Anti-B antigens present in its plasma Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Rh Factor • Rh positive (Rh+) – Rh antigen is present on the RBC • Rh negative (Rh-) – Rh antigen not present on the RBC • Concern: Rh- blood being exposed to Rh+ blood via transfusion • Concern: Rh- mother giving birth to Rh+ baby and blood mixes during birth process Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Blood Clotting • Clotting of blood = coagulation – Injury to blood vessel creates roughened area in vessel – Platelets come in contact with rough spot and disintegrate • Release substance called thromboplastin – Thromboplastin converts prothrombin into thrombin • In presence of calcium ions and other clotting factors – Thrombin converts fibrinogen into fibrin • Fibrin threads form a mesh that forms the clot Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Question The Red Cross loves to call a person with this blood type: a. b. c. d. A B AB O Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. PATHOLOGICAL CONDITIONS The Blood Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Anemia • Pronounced – (an-NEE-mee-ah) • Defined – Deficiency of oxygen being delivered to cells due to decrease in quantity of hemoglobin or red blood cells Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Anemia • Similarities in all types of anemia – – – – Fatigue Paleness of skin Headache Fainting Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Anemia • Similarities in all types of anemia – – – – Tingling sensations and numbness Loss of appetite Swelling in lower extremities Difficulty breathing Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Aplastic Anemia • Pronounced – (ah-PLAST-ik an-NEE-mee-ah) • Defined – Form of anemia characterized by pancytopenia, an inadequacy of all the formed blood elements (RBCs, WBCs, platelets) – Also known as “bone marrow depression anemia” Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Hemolytic Anemia • Pronounced – (he-moh-LIT-ik an-NEE-mee-ah) • Defined – Form of anemia characterized by the extreme reduction in circulating RBCs due to their destruction Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Iron Deficiency Anemia • Pronounced – (EYE-urn dee-FIH-shen-see an-NEEmee-ah) • Defined – Anemia that is characterized by deficiency of hemoglobin level due to a lack of iron in the body Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Pernicious Anemia • Pronounced – (per-NISH-us an-NEE-mee-ah) • Defined – Form of anemia resulting from a deficiency of mature RBCs and the formation and circulation of megaloblasts, with marked poikilocytosis and anisocytosis • Distorted RBCs due to lack of vitamin B12 absorption necessary for maturation of RBCs Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Sickle Cell Anemia • Pronounced – (SIKL SELL an-NEE-mee-ah) • Defined – Chronic hereditary form of hemolytic anemia in which RBCs become crescent-shaped in presence of low oxygen concentration • Crescent-shaped RBCs clump together forming thromboses which occlude small blood vessels, causing much pain for the individual Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Question True or False: The breakdown of anemia is an = without, -emia = blood condition (noun form). Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Granulocytosis • Pronounced – (gran-yew-loh-sigh-TOH-sis) • Defined – Abnormally elevated number of granulocytes in the circulating blood as a reaction to any variety of inflammation or infection Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Hemochromatosis • Pronounced – (hee-moh-kroh-mah-TOH-sis) • Defined – Rare iron metabolism disease characterized by iron deposits throughout the body – Usually as a complication of one of the hemolytic anemias Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Hemophilia • Pronounced – (hee-moh-FILL-ee-ah) • Defined – Hereditary inadequacies of coagulation factors resulting in prolonged bleeding times Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Hemophilia • Hemophilia A – Also called classic hemophilia – Result of a deficiency or absence of antihemophilic factor VIII • Deficiency results in traumatic or spontaneous bleeding – Characterized by bleeding in joints, gums, or mouth – Hematuria is a common characteristic Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Hemophilia • Hemophilia B – Also called Christmas disease – Result of deficiency of a coagulation factor called factor IX – Only distinguishable from hemophilia A through laboratory differentiation of factor deficiencies Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Leukemia • Pronounced – (loo-KEE-mee-ah) • Defined – Excessive uncontrolled increase of immature WBCs in the blood, eventually leading to infection, anemia, and thrombocytopenia • Course of leukemia is subclassified as acute or chronic Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Leukemia • Acute leukemia – Rapid onset – Swiftly progresses to severe thrombocytopenia, progressive anemia, infective lesions in throat and mouth, high fever, and severe infection • Chronic leukemia – Gradual onset – Progression slower than with acute form Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Leukemia • Classifications of leukemia – AML • Acute myelogenous leukemia – ALL • Acute lymphocytic leukemia Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Leukemia • Classifications of leukemia – CML • Chronic myelogenous leukemia – CLL • Chronic lymphocytic leukemia Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Question True or False: Granulocytosis is an overreaction by the WBCs with granules to inflammation and infection. Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Multiple Myeloma (Plasma Cell Myeloma) • Pronounced – (MULL-tih-pl my-eh-LOH-mah) • Defined – Malignant plasma cell neoplasm causing an increase in the number of both mature and immature plasma cells • Often entirely replaces the bone marrow and destroys the skeletal structure Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Polycythemia Vera • Pronounced – (pol-ee-sigh-THEE-mee-ah VAIR-ah) • Defined – Abnormal increase in the number of RBCs, granulocytes, and thrombocytes leading to an increase in blood volume and viscosity Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Purpura • Pronounced – (PURR-pew-rah) • Defined – Collection of blood beneath the skin in the form of pinpoint hemorrhages appearing as red-purple skin discolorations • Idiopathic thrombocytopenic purpura = antibodies formed by the individual that destroy his/her own platelets Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Thalassemia • Pronounced – (thal-ah-SEE-mee-ah) • Defined – Hereditary form of hemolytic anemia in which the production of hemoglobin is deficient, creating hypochromic microcytic RBCs • Alpha or beta hemoglobin chains are defective Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. DIAGNOSTIC TECHNIQUES, TREATMENTS, AND PROCEDURES The Blood Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Diagnostic Techniques, Treatments, and Procedures • Direct antiglobulin test (Coomb’s test) – Blood test used to discover the presence of antierythrocyte antibodies present in the blood of an Rhnegative woman • Production of these antibodies is associated with an Rh incompatibility between a pregnant Rh-negative woman and her Rh-positive fetus Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Diagnostic Techniques, Treatments, and Procedures • Bleeding time – Measurement of the time required for bleeding to stop • Blood transfusion – Administration of blood or a blood component to an individual to replace blood lost through surgery, trauma, or disease Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Diagnostic Techniques, Treatments, and Procedures • Bone marrow biopsy – Microscopic exam of bone marrow tissue, which fully evaluates hematopoiesis by revealing the number, shape, and size of the RBCs, WBCs, and platelet precursors • Bone samples are obtained through aspiration or surgical removal Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Diagnostic Techniques, Treatments, and Procedures • Bone marrow transplant – Donor’s bone marrow cells are infused intravenously into the recipient • After recipient receives an infusion of aggressive chemotherapy or total-body irradiation to destroy all malignant cells and to inactivate the immune system Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Diagnostic Techniques, Treatments, and Procedures • Complete blood cell count (CBC) – Series of tests performed on peripheral blood, which inexpensively screens for problems in the hematologic system as well as several other organ systems – CBC includes: • RBC count, hemoglobin, hematocrit, RBC indices, WBC count, WBC differential, blood smear, platelet count Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Diagnostic Techniques, Treatments, and Procedures • Erythrocyte sedimentation rate (ESR) – Test performed on blood, which measures the rate at which red blood cells settle out in a tube of unclotted blood • ESR is determined by measuring the settling distance of RBCs in normal saline over one hour Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Question When a blood transfusion is autologous, it means: a. b. c. d. it came from the patient. it came from a family member. the blood is compatible with the patient. it passes from the donor to the recipient in real time. Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Diagnostic Techniques, Treatments, and Procedures • Hematocrit – Assessment of RBC percentage in total blood volume • Hemoglobin test – Concentration measurement of hemoglobin in peripheral blood Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Diagnostic Techniques, Treatments, and Procedures • Lipid profile – Measurement of the lipids in the blood • Partial thromboplastin time (PTT) – Blood test used to evaluate the common pathway and system of clot formation within the blood Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Diagnostic Techniques, Treatments, and Procedures • Platelet count – Blood test that provides the count of platelets per cubic millimeter of blood • Prothrombin time (PT) – Blood test used to evaluate common pathway and extrinsic system of clot formation Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Diagnostic Techniques, Treatments, and Procedures • Red blood cell count (RBC) – Measurement of the circulating number of RBCs in 1 mm3 of peripheral blood • Red blood cell morphology – Examination of the RBC on a stained blood smear that enables the examiner to identify the form and shape of the RBCs Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Diagnostic Techniques, Treatments, and Procedures • Reticulocyte count – Measurement of the number of circulating reticulocytes (immature erythrocytes) in a blood specimen • Rouleaux – Aggregation of RBCs viewed through the microscope that may be an artifact, or may occur with persons with multiple myeloma as a result of abnormal proteins Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Diagnostic Techniques, Treatments, and Procedures • Schilling test – Diagnostic analysis for pernicious anemia • White blood cell count (WBC) – Measurement of the circulating number of WBCs in 1 mm3 of peripheral blood Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Diagnostic Techniques, Treatments, and Procedures • White blood cell differential – Measurement of the percentage of each specific type of circulating WBCs present in 1 mm3 of peripheral blood drawn for the WBC count Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Question What collective test takes care of evaluating RBCs, WBCs, hemoglobin, hematocrit, and platelet count? a. b. c. d. erythrocyte sedimentation rate complete blood count bone marrow biopsy Schilling test Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Lymphatic System Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Lymphatic System Overview • Lymphatic system functions to produce antibodies and lymphocytes important to immunity • Lymphatic system also functions to maintain a balance of fluid in the internal environment Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Lymphatic System Overview • Lymphatic system – Lymph fluid • Stems from the blood and tissue fluid – Lymph vessels • Similar to blood vessels – designed to return tissue fluid to bloodstream Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Lymphatic System Overview • Lymphatic system – Lymph nodes • Located along path of collecting vessels – Lymphatic organs • Thymus, spleen, and tonsils Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Lymphatic System Overview • How lymph vessels differ from blood vessels – Lymph vessels do not form a closed circuit as does the cardiovascular system – Lymph vessels originate in intercellular spaces of soft tissues of the body Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Lymphatic System Overview • Important part of the immune system – Immune system consists of: • • • • • • Bone marrow Thymus Lymphoid tissues Lymph nodes Spleen Lymphatic vessels Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Question True or False: The lymphatic system is not involved in cell production. Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Lymph Vessels • Lymph capillaries – Smallest lymphatic vessels – Originate in tissue spaces as blind-ended sacs – Capillaries pick up accumulated interstitial fluid and return it to the blood – Fluid inside the lymphatic vessels is known as lymph Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Lymph Vessels • Lymph vessels – – – – Larger than capillaries Receive lymph from lymphatic capillaries Valves prevent backward flow of fluid Transport fluid in only one direction • Away from the tissues toward the thoracic cavity Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Lymph Vessels • Lymphatic ducts – Only points of entry of lymph into blood vessels of body – Right lymphatic duct • Receives lymph drainage from right side of head and neck • Also receives lymph drainage from right upper extremity and right side of chest • Empties into right subclavian vein Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Lymph Vessels • Lymphatic ducts – Thoracic duct • Receives lymph drainage from remaining regions of the body • Empties into left subclavian vein Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Lymph Nodes • Collections of lymphatic tissue • Also called lymph glands • Located at intervals along course of lymphatic system vessels Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Lymph Nodes • Lymph passes through stationary lymph nodes – Old, dead cells and bacteria present in lymph are filtered out – Macrophages engulf and destroy any bacteria present Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Thymus • Located in mediastinum • Secretes thymosin – stimulates red bone marrow to produce T lymphocytes – T cells important in immune response – T cells mature in the thymus Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Spleen • Located in upper left quadrant of abdomen, just below diaphragm, behind stomach • Largest lymphatic organ in the body Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Spleen • Plays an important role in the immune response – Filters blood – Macrophages of spleen remove pathogens from circulating blood – Macrophages also remove old red blood cells from circulation Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Tonsils • Masses of lymphatic tissue • Located in protective ring, just under the mucous membrane • Surround the mouth and back of the throat • Serve as first line of defense from the external environment Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Tonsils • Three groups – Pharyngeal tonsils or adenoids • Located near opening of the nasal cavity into pharynx (throat) – Palatine tonsils • Located on each side of the throat, near opening of oral cavity into pharynx • Commonly known as ‘the tonsils’ Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Tonsils • Three groups – Lingual tonsils • Located near the base of the tongue Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Question The lymph capillaries pass interstitial fluid to the blood capillaries, but there are ducts connecting the lymph vessels with the blood vessels. How many are there? a. b. c. d. 2 8 14 20 Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Immunity • Natural – Immunity with which we are born; genetic • Acquired – Body has developed ability to defend itself against a specific agent • Can occur as result of having had the particular disease • Can be result of having received immunizations against a disease • Can be passive acquired immunity or active acquired immunity Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Immunity • Passive acquired immunity – Acquired artificially by injecting antibodies into a person’s body – Protects person from a specific disease – Short-lived immunity – lasts only a few weeks – Example: gamma globulin • Given to individuals exposed to viruses such as measles and infectious hepatitis Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Immunity • Active acquired immunity – Acquired naturally as result of having had a disease – Acquired artificially by being inoculated with a vaccine, antigen, or toxoid • Immunization = process of creating immunity to a specific disease Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Immune Reaction • Immune reaction = Immune response – Defense mechanism of the body • Produces antibodies to destroy invading antigens and malignancies • Humoral immune response – B lymphocytes come in contact with specific invading antigens • Produce antibodies known as immunoglobulins Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Immune Reaction • Cell-mediated immune response – T lymphocytes come in contact with specific invading antigens – T lymphocytes multiply rapidly and engulf and digest the antigen • Multiplication of cells produces memory cells • Memory cells provide the body with resistance Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Hypersensitivity • Abnormal condition characterized by an excessive reaction to a particular stimulus • Body’s immune system fails to protect itself against foreign material • Allergic reaction is triggered by an allergen – Examples of allergens: • Ingested foods, penicillin and other antibiotics, grass, ragweed pollen, and bee or wasp stings Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Hypersensitivity • Hypersensitive reactions – Local reaction • Occurs at the site where treatment or medication was administered – Systemic reaction • Evidenced by generalized body symptoms such as runny nose, itchy eyes, hives, and rashes Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Hypersensitivity • Hypersensitive reactions – Anaphylactic shock • Also known as anaphylaxis • Antigen-antibody reaction stimulates a massive secretion of histamine • Example causes: – Insect stings, contrast media containing iodide, aspirin, antitoxins prepared with animal serum, allergens used in testing Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Question True or False: Memory cells are not that important to immunity and just end up being “leftover” cells after an immune response. Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. PATHOLOGICAL CONDITIONS Lymphatic System Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Acquired Immunodeficiency Syndrome (AIDS) • Pronounced – (acquired ih-mew-noh-dee-FIH-shen-see SIN-drohm) • Defined – Clinical conditions that destroy the body’s immune system in the last or final phase of a human immunodeficiency virus (HIV) infection, which primarily damages helper T-cell lymphocytes with CD4 receptors Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Cytomegalovirus • Pronounced – (sigh-toh-meg-ah-loh-VY-rus) • Defined – Large species-specific, herpes-type virus with a wide variety of disease effects – Causes serious illness in persons with AIDS, in newborns, and in individuals who are being treated with immunosuppressive drugs Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Hypersensitivity • Pronounced – (high-per-sens-sih-TIV-ih-tee) Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Hypersensitivity • Defined – Tissue damage resulting from exaggerated immune responses • • • • IgE-mediated type I hypersensitivity response Cytoxic type II hypersensitivity reaction Immune complex-mediated type III sensitivity response Delayed type IV hypersensitivity response Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Hypersplenism • Pronounced – (high-per-SPLEN-izm) • Defined – Syndrome involving a deficiency of one or more types of blood cells and an enlarged spleen Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Kaposi’s Sarcoma • Pronounced – (KAP-oh-seez sar-KOH-mah) • Defined – Locally destructive malignant neoplasm of the blood vessels associated with AIDS, typically forming lesions on the skin, visceral organs, or mucous membranes • Lesions appear initially as tiny red to purple macules and evolve into sizable nodules or plaques Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Lymphoma • Pronounced – (LIM-foh-mah) • Define – A lymphoid tissue neoplasm that is typically malignant, beginning with painless enlarged lymph node(s) and progressing to anemia, weakness, fever, and weight loss Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Lymphoma • Burkitt’s lymphoma – Malignant neoplasm in the jaw or abdomen and seen chiefly in Central Africa • Hodgkin’s disease – Characterized by progressive, painless enlargement of a malignant tumor of the lymph tissue in the lymph nodes and spleen, typically noted first in the cervical region Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Lymphoma • Non-Hodgkin’s lymphoma – Classification for any kind of malignant lymphoma besides Hodgkin’s disease – Includes histiocyte lymphoma and lymphocytic lymphoma Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Question What condition would you NOT see with AIDS? a. b. c. d. cytomegalovirus lymphoma hypersensitivity Kaposi's sarcoma Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Mononucleosis • Pronounced – (mon-oh-noo-klee-OH-sis) • Defined – A benign, self-limiting acute infection of the B lymphocytes – Usually caused by the Epstein-Barr virus (EBV) Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Myasthenia Gravis • Pronounced – (my-ass-THEE-nee-ah GRAV-is) • Defined – An autoimmune disease in which antibodies block or destroy some acetylcholine receptor sites – Results in muscle weakness Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Pneumocystis Carinii Pneumonia (PCP) • Pronounced – (noo-moh-SIS-tis kah-rye-nee-eye noo-MOH-nee-ah) • Defined – Pneumonia caused by a common worldwide parasite, Pneumocystis carinii, for which people have immunity if they are not severely immunocompromised Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Sarcoidosis • Pronounced – (sar-koyd-OH-sis) • Defined – Systemic inflammatory disease resulting in the formation of multiple small, rounded lesions (granulomas) in the lungs, lymph nodes, eyes, liver, and other organs Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Systemic Lupus Erythematosus (SLE) • Pronounced – (sis-TEM-ik LOO-pus air-ih-them-ah-TOH-sus) • Defined – Inflammatory connective tissue disease, chronic in nature, in which immune complexes are formed from the reaction of SLE autoantibodies and their corresponding antigens • These immune complexes are deposited in the connective tissues of lymphatic vessels, blood vessels, and other tissues Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. DIAGNOSTIC TECHNIQUES, TREATMENTS, AND PROCEDURES Lymphatic System Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Diagnostic Techniques, Treatments, and Procedures • Enzyme-linked immunosorbent assay (ELISA) – Blood test used for screening for an antibody to the AIDS virus • Western blot – Blood test to detect the presence of the antibodies to HIV, the virus that causes AIDS Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Diagnostic Techniques, Treatments, and Procedures • CT (CAT) scan – Collection of x-ray images taken from various angles following an injection of a contrast medium • Lymphangiogram – X-ray assessment of the lymphatic system following injection of a contrast medium into the lymph vessels in the hand or foot Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED. Question True or False: Contrast is needed when imaging the lymphatic system to illuminate the flow of fluid through its vessels and tissues. Copyright © 2011 Delmar, Cengage Learning. ALL RIGHTS RESERVED.