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Chapter 5: Associative Learning And Unlearning From Mechanisms of Memory, second edition By J. David Sweatt, Ph.D. Purkinje Neuron Chapter 5 Terminology of Associative Conditioning Figure 1 Stimulus or Response Term Abbreviation Actual Stimulus or Response by the Dog in Pavlov’s Experiments Conditioned Stimulus CS A Ringing Bell Unconditioned Stimulus US Food Unconditioned Response UR Salivation Conditioned Response CR Salivation Pavlov and one of his Dogs Figure 2 Nonsocial and Social Fear Learning in Humans Figure 3 Fear Learning in Human Amygdala Figure 4 Anatomy of the Fear System Figure 5 Terje Lomo and Tim Bliss 1969 Figure 6 2003 Long-term Potentiation in the Amygdala Figure 7 Tone CS Auditory Thalamus/ Auditory Cortex Medial Geniculate Nucleus Lateral Nucleus of Amygdala Thalmic inputs Cortical inputs Shock US CS Central Nucleus Defensive Responses Figure 8 US Weak Strong CS Paired Activity US Strong Strong Fear Conditioning Results in Potentiation Figure 9 Effect of Paired/Unpaired Training on CS Figure 10 Eye-blink Conditioning in Rabbits Corneal Air Puff Elicits Eyeblink Response Figure 11 Corneal Air Puff Given with Tone Tone Given Alone Elicits Eyeblink Response Diagram of the Neural Circuit LTD Mossy Fibers Granule Cells Tone (Conditioned Stimulus) Purkinje Neurons Parallel Fibers Climbing Fibers Purkinje Cells Inferior Olivary Complex GABA VIII Nerve Pontine Nuclei Nucleus Interpositus Red Nucleus Facial Nerve Motor Neuron Eyeblink Response Figure 12 Trigeminal (V) Ganglion Corneal Air Puff (Unconditioned Stimulus) Auditory Cue Reward Learning Bar Press = CUED Reward Bar Press = No Reward Figure 13 UNCUED Diagram of the Limbic Corticostriatal Loop Figure 14 The Honeybee A B Blue Box 2 Olfactory Learning in Drosophila-The Fruitfly Blue Box 3 Pavlovian Conditioning in Hermissenda Blue Box 4 The Pond Snail Lymnaea Blue Box 3 A Pigeon in a “Skinner Box” Blue Box 7 Birdbrains Species Pigeon Chicken (hatchling) Canaries, Finches Chickadees, Nutcrackers, Blue Jays Barn Owls Crows Blue Box 8 Behavior Pecking, bar-pressing Instinctive bead-pecking Song learning Seed caching Visual system adaptation Tool making Type of Learning/Memory Operant conditioning Conditioned taste aversion Declarative memory? Language? Spatial memory Motor adaptation learning Motor learning, instrumental learning