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SCHIZOPHRENIA A trip into madness What Schizophrenia Is Not: It is not split personality (or multiple personality disorder) What is split in schizophrenia is not so much personality as the connections among thoughts Schizophrenia is a psychotic disorder… people are out of touch with reality Evidence in the Brain Onset Onset occurs between the late teens and mid-30s. Onset prior to adolescence rare. The onset could be abrupt/acute(fast) or insidious(slow) majority of individuals display some type of slow and gradual development of a variety of signs and symptoms Prevalence and Familial Pattern Between .5% and 1.5% of adults are believed to have schizophrenia Causes Genetic Biological -different brain structure -high dopamine levels -amphetamines make it worse Viral infections during pregnancy Stress Theory- predisposition and certain level of stress (college??) Diagnostic criteria for Schizophrenia: Criterion A: Two (or more) of the following, each present for a significant portion of the time during a 1-month period (or less if successfully treated): 1. Delusions 2. Hallucinations 3. Disorganized speech 4. Grossly disorganized or catatonic behavior 5. Negative symptoms Delusions Delusions: False beliefs or thoughts that resists all argument or clear proof. Delusions make sense and sufferers do not question them even if the delusions are scary or threatening Types of Delusions: 1. Persecution 2. Reference 3. Control 4. Thought insertion 5. Thought withdraw 6. Grandeur Delusions Persecution: someone (or everyone) is out to get you Reference: External people/objects send signs or messages to you. (Ex. Billboards or commercials speak specifically to you) Control: controlled by some outside force (Satan made you do it) Thought Insertion: other people are putting thoughts into your head Thought Withdraw: people are taking thoughts out of your head (others can know your thoughts) Grandeur: belief of greater abilities than you actually possess (Ex. Think you can fly, believe you are God) Hallucinations Hallucinations: False sensory experiences that can come in the form of auditory or visual. Most common are auditory “hearing voices” What do the voices say? Command them to act (usually against themselves) Voices say cruel and hateful things about the person Where do the voices come from? Outside Disorganized Speech This is what makes sufferers look “crazy”! Some believe this to be the single most important feature “slip off track” Types: 1.Loose associations 2.Tangentiality 3.Neologisms 4.Preserevation 5.Clanging 6.Blocking Disorganized Speech Loose associations: jump from one idea or topic to the next in the same sentence. ~sometimes called word salad Tangentiality: when asked a question, go off on unrelated topic Neologisms: create new words or new meanings for words Preserevation: repeat same sound or word Clanging: choose words by sound, not meaning Blocking: stop mid-sentence Grossly Disorganized Behavior May manifest itself in a variety of ways Problems with goal-directed behavior Problems performing activities of daily living Person may appear markedly disheveled or may dress in an unusual manner Display clearly inappropriate sexual behavior Unpredictable and untriggered agitation Negative Symptoms Absence of something that should be there Types: Affective flattening: no emotion Alogia: missing speech (won’t speak/appropriateness of speech) Avolition: lack of motivation Anhedonia: inability to feel pleasure Note for Criterion A: Only one Criterion A symptom is required if delusions are bizarre or hallucinations consist of a voice keeping up a running commentary on the person’s behavior or thought, or two or more voices conversing with each other (Bizarre= not possible) Criterion B: Social/Occupational Dysfunction A significant portion of the time since the onset, one or more major areas of functioning, such as work, interpersonal functioning, or self-care are markedly below the level achieved prior to the onset (or when the onset is in childhood or adolescence, failure to achieve expected level of interpersonal, academic, or occupational achievement). Social/Occupational Dysfunction Examples for adults: 1. Fired from a job 2. Loses friends 3. Mismatched dress, unkempt Examples for children: 1. Trouble making/keeping friends 2. Trouble in school 3. Trouble with play or completing normal “kid” tasks Criterion C: Duration Continuous signs of the disturbance persist for at least SIX months. This six month period must include at least ONE month of symptoms (or less if successfully treated) that meet Criterion A (i.e. active phase symptoms) and may include periods of prodromal or residual symptoms. During these prodromal or residual, the signs of the disturbance may be manifested by only negative symptoms or two or more symptoms listed in Criterion A present in an attenuated form (e.g. odd beliefs, unusual perceptual experiences). Criterion D: Schizoaffective and Mood disorder exclusion Schizoaffective disorder and Mood Disorder with psychotic features have been ruled out because either (1) no major depressive, manic or mixed episode have occurred concurrently with active phase symptoms; or (2) if mood episodes have occurred during active phase symptoms, their total duration has been brief relative to the duration of the active and residual periods. Criterion E: Substance/general medical condition exclusion The disturbance is not due to the direct physiological effects of a substance (e.g. a drug of abuse, a medication) or a general medical condition. Criterion F: Relationship to a Pervasive Developmental Disorder If there is a history of Autistic Disorder or another Pervasive Developmental Disorder, the additional diagnosis of Schizophrenia is made only if prominent delusions or hallucinations are also present for at least a month (or less if successfully treated). Subtypes: The subtypes of Schizophrenia are defined by the predominant symptomatology at the time of evaluation. There is an order to follow if two or more subtype’s symptoms are present. Which goes like this… 1. 2. 3. 4. Catatonic Type Disorganized Type Paranoid Type Undifferentiated Type Subtypes Catatonic Type: Marked psychomotor disturbance Immobility Excessive motor activity Extreme negativism Mutism Echolalia- repetitive sound Echopraxia- repetitive movement Disorganized Type: Strangest and sickest of sufferers Course type is usually continuous “CRAZY” – “true madness” Subtypes: Paranoid Type: Usually centered around one delusion Basic theme Hard to treat because they don’t trust anyone – esp. the therapist Undifferentiated Type ~The catch-all category Treatments Psychotic medicine helps to reduce symptoms, however, there is NO cure for Schizophrenia. Not all people respond to medicine. Seroquel Abilify Zyprexa Risperdal Geodon Haldol Thorazine Clozaril Trilafon Stelazine