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DEPRESSIVE DISORDERS IN OTHER SELECTED MEDICAL CONDITIONS FRANCIS CREED & SANTOSH K CHATURVEDI Copyright © 2012. World Psychiatric Association SYMPTOMS SHARED BY RHEUMATOID ARTHRITIS AND DEPRESSIVE DISORDER • • • • • Feeling helpless and hopeless Inability to work Insomnia Lack of energy General poor health Copyright © 2012. World Psychiatric Association 2 HEPATOTOXICITY & ANTIDEPRESSANTS • Most antidepressants undergo extensive hepatic oxidative metabolism and should be dosed cautiously • Antidepressants can cause hepatitis, at times • Most antidepressant agents have the potential to produce idiopathic liver injury. • Possible drug discontinuation syndromes can occur if antidepressants are stopped due to hepatotoxicity. • Consider early discontinuation of an antidepressant if hepatotoxicity is suspected. • Idiopathic drug-induced liver injury cannot be prevented, but the severity of the reaction may be minimized with prompt recognition and early withdrawal of the agent. • Ongoing therapy of the underlying depressive disorder should be provided using psychological or safe pharmacological methods Copyright © 2012. World Psychiatric Association 3 ETIOLOGY OF DEPRESSION IN RENAL DISEASE: • Metabolic changes, including sedative accumulation • Other drug-induced metabolic disturbances, • Psychosocial aspects of chronic renal failure, such as restrictions imposed by the need for lifelong dialysis. • Stressful life events and dependence on family or others for help • Electrolyte disturbances involving sodium, potassium, calcium, chloride, phosphate, and acid-base balance. • Related to treatment – steroids, immunosuppressants, dialysis, or transplantation Copyright © 2012. World Psychiatric Association 4 Inter relationship between Chronic Pain & Depression • • • • • Depression can present with chronic pain Chronic pain can cause depression Aches and pains may be symptoms of Depression Chronic pain may be a variant of depression Depression can worsen chronic pain Copyright © 2012. World Psychiatric Association 5 Psychiatric Management of Chronic pain & Depression • • • • Appropriate use of antidepressants Explaining the relationship between pain and depression Reattribution of pain to mood and depression Rehabilitation and Living with pain Copyright © 2012. World Psychiatric Association 6 Use of Antidepressants for Chronic Pain 1. 2. 3. 4. 5. 6. Elevation of Mood Reduction of Anxiety Potentiation Of Analgesics Primary Analgesic Effect Relief From Non-Organic Causes of pain Reduces psychological symptoms as restlessness, agitation, sleep disturbance Copyright © 2012. World Psychiatric Association 7