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Platelets
Neutrophils
Erythrocytes
Monocyte
Lymphocyte
2.5 µm
Side view (cut)
7.5 µm
Top view
Stem cell
Hemocytoblast
Committed
cell
Proerythroblast
Developmental pathway
Phase 1
Ribosome
synthesis
Phase 2
Hemoglobin
accumulation
Early
Late
erythroblast erythroblast
Phase 3
Ejection of
nucleus
Normoblast
Reticulo- Erythrocyte
cyte
Differential
WBC count
(All total 4800 –
10,800/l)
Formed
elements
Platelets
Leukocytes
Granulocytes
Neutrophils (50 – 70%)
Eosinophils (2 – 4%)
Basophils (0.5 – 1%)
Erythrocytes
Agranulocytes
Lymphocytes (25 – 45%)
Monocytes (3 – 8%)
(a) Neutrophil;
multilobed
nucleus
(b) Eosinophil;
bilobed nucleus,
red cytoplasmic
granules
(c) Basophil;
bilobed nucleus,
purplish-black
cytoplasmic
granules
(d) Small
lymphocyte;
large spherical
nucleus
(e) Monocyte;
kidney-shaped
nucleus
Stem cell
Developmental pathway
Hemocytoblast
Promegakaryocyte
Megakaryoblast
Megakaryocyte
Platelets
Step 1 Vascular spasm
• Smooth muscle contracts,
causing vasoconstriction.
Collagen
fibers
Step 2 Platelet plug
formation
• Injury to lining of vessel
exposes collagen fibers;
platelets adhere.
• Platelets release chemicals
that make nearby platelets
sticky; platelet plug forms.
Platelets
Fibrin
Step 3 Coagulation
• Fibrin forms a mesh that traps
red blood cells and platelets,
forming the clot.
Superior
vena cava
Aorta
Parietal
pleura (cut)
Pulmonary
trunk
Left lung
Pericardium
(cut)
Diaphragm
Apex of
heart
Pulmonary
trunk
Pericardium
Myocardium
Fibrous pericardium
Parietal layer
Pericardial cavity
Epicardium
(visceral layer)
Myocardium
Endocardium
Heart chamber
Brachiocephalic trunk
Superior vena cava
Right pulmonary
artery
Ascending aorta
Pulmonary trunk
Right pulmonary
veins
Right atrium
Right coronary artery
(in coronary sulcus)
Anterior cardiac vein
Right ventricle
Right marginal artery
Small cardiac vein
Inferior vena cava
Left common carotid
artery
Left subclavian artery
Aortic arch
Ligamentum arteriosum
Left pulmonary artery
Left pulmonary veins
Auricle of
left atrium
Circumflex artery
Left coronary artery
(in coronary sulcus)
Left ventricle
Great cardiac vein
Anterior interventricular
artery (in anterior
interventricular sulcus)
Apex
Aorta
Left pulmonary
artery
Superior vena cava
Left pulmonary
veins
Auricle of left
atrium
Left atrium
Great cardiac
vein
Right pulmonary veins
Posterior vein
of left ventricle
Left ventricle
Apex
Right pulmonary artery
Right atrium
Inferior vena cava
Coronary sinus
Right coronary artery
(in coronary sulcus)
Posterior
interventricular
artery (in posterior
interventricular sulcus)
Middle cardiac vein
Right ventricle
Aorta
Superior vena cava
Right pulmonary
artery
Pulmonary trunk
Right atrium
Right pulmonary
veins
Fossa ovalis
Pectinate muscles
Tricuspid valve
Right ventricle
Chordae tendineae
Trabeculae carneae
Inferior vena cava
Left pulmonary
artery
Left atrium
Left pulmonary
veins
Mitral (bicuspid)
valve
Aortic valve
Pulmonary valve
Left ventricle
Papillary muscle
Interventricular
septum
Epicardium
Myocardium
Endocardium
Pulmonary
Circuit
Pulmonary arteries
Venae cavae
Capillary beds
of lungs where
gas exchange
occurs
Pulmonary veins
Aorta and branches
Left atrium
Left ventricle
Right atrium
Right ventricle
Oxygen-rich,
CO2-poor blood
Oxygen-poor,
CO2-rich blood
Heart
Systemic
Circuit
Capillary beds of all
body tissues where
gas exchange occurs
Superior
vena cava
Anastomosis
(junction of
vessels)
Right
atrium
Aorta
Pulmonary
trunk
Left atrium
Left
coronary
artery
Circumflex
artery
Right
coronary
Left
artery
ventricle
Right
ventricle
Anterior
Right
interventricular
marginal Posterior
artery
artery
interventricular
artery
The major coronary arteries
Superior
vena cava
Anterior
cardiac
veins
Great
cardiac
vein
Coronary
sinus
Small cardiac vein
Middle cardiac vein
The major cardiac veins
QRS complex
Sinoatrial
node
Atrial
depolarization
Ventricular
depolarization
Ventricular
repolarization
Atrioventricular
node
P-Q
Interval
S-T
Segment
Q-T
Interval
Venous system
Large veins
(capacitance
vessels)
Arterial system
Heart
Large
lymphatic
vessels
Lymph
node
Lymphatic
system
Small veins
(capacitance
vessels)
Elastic arteries
(conducting
vessels)
Muscular arteries
(distributing
vessels)
Arteriovenous
anastomosis
Sinusoid
Lymphatic
capillary
Arterioles
(resistance vessels)
Postcapillary
venule
Thoroughfare
channel
Terminal arteriole
Metarteriole
Precapillary sphincter
Capillaries
(exchange vessels)
Precapillary
sphincters
Vascular shunt
Metarteriole
Thoroughfare channel
True capillaries
Terminal arteriole
Postcapillary venule
(a) Sphincters open—blood flows through true capillaries.
Terminal arteriole
Postcapillary venule
(b) Sphincters closed—blood flows through metarteriole
thoroughfare channel and bypasses true capillaries.
Arteries of the head and trunk
Internal carotid artery
External carotid artery
Common carotid arteries
Vertebral artery
Subclavian artery
Brachiocephalic trunk
Aortic arch
Ascending aorta
Coronary artery
Thoracic aorta (above
diaphragm)
Arteries that supply
the upper limb
Subclavian artery
Axillary artery
Brachial artery
Radial artery
Ulnar artery
Deep palmar arch
Celiac trunk
Superficial palmar arch
Abdominal aorta
Digital arteries
Superior mesenteric artery
Renal artery
Gonadal artery
Common iliac artery
Inferior mesenteric artery
Internal iliac artery
Arteries that supply
the lower limb
External iliac artery
Femoral artery
Popliteal artery
Anterior tibial artery
Posterior tibial artery
Arcuate artery
Ophthalmic artery
Basilar artery
Vertebral artery
Internal
carotid artery
External
carotid artery
Common
carotid artery
Thyrocervical
trunk
Costocervical
trunk
Subclavian
artery
Axillary
artery
Branches of
the external
carotid artery
• Superficial
temporal artery
• Maxillary artery
• Occipital artery
• Facial artery
• Lingual artery
• Superior thyroid
artery
Larynx
Thyroid gland
(overlying trachea)
Clavicle (cut)
Brachiocephalic
trunk
Internal thoracic
artery
Arteries of the head and neck, right aspect
Anterior
Frontal lobe
Optic chiasma
Cerebral arterial
circle
(circle of Willis)
• Anterior
communicating
artery
• Anterior
cerebral artery
• Posterior
communicating
artery
• Posterior
cerebral artery
Basilar artery
Middle
cerebral
artery
Internal
carotid
artery
Mammillary
body
Temporal
lobe
Pons
Occipital lobe
Vertebral artery
Cerebellum
Posterior
Major arteries serving the brain (inferior view, right side
of cerebellum and part of right temporal lobe removed)
Vertebral artery
Thyrocervical trunk
Suprascapular artery
Costocervical trunk
Thoracoacromial artery
Axillary artery
Posterior circumflex
humeral artery
Anterior circumflex
humeral artery
Subscapular artery
Brachial artery
Deep artery of arm
Common
interosseous
artery
Common carotid
arteries
Left subclavian artery
Right subclavian artery
Brachiocephalic trunk
Posterior intercostal
arteries
Anterior intercostal
artery
Internal thoracic artery
Descending aorta
Lateral thoracic artery
Radial artery
Ulnar artery
Deep palmar arch
Superficial palmar arch
Digital arteries
Illustration, anterior view
Veins of the head and trunk
Dural venous sinuses
External jugular vein
Vertebral vein
Internal jugular vein
Right and left
brachiocephalic veins
Superior vena cava
Great cardiac vein
Hepatic veins
Splenic vein
Hepatic portal vein
Renal vein
Veins that drain
the upper limb
Subclavian vein
Axillary vein
Cephalic vein
Brachial vein
Basilic vein
Median cubital vein
Ulnar vein
Radial vein
Digital veins
Veins that drain
the lower limb
Superior mesenteric
vein
Inferior vena cava
Inferior mesenteric vein
External iliac vein
Common iliac vein
Popliteal vein
Internal iliac vein
Posterior tibial vein
Femoral vein
Great saphenous vein
Anterior tibial vein
Illustration, anterior
view. The vessels of the
pulmonary circulation
are not shown.
Small saphenous vein
Dorsal venous arch
Dorsal metatarsal veins
Superficial temporal
vein
Occipital vein
Posterior
auricular vein
External
jugular vein
Ophthalmic vein
Facial vein
Vertebral vein
Internal jugular
vein
Superior and middle
thyroid veins
Brachiocephalic
vein
Subclavian vein
Superior
vena cava
Veins of the head and neck, right superficial aspect
Brachiocephalic veins
Right subclavian vein
Axillary vein
Brachial vein
Cephalic vein
Basilic vein
Median cubital vein
Internal jugular vein
External jugular vein
Left subclavian vein
Superior vena cava
Azygos vein
Accessory hemiazygos
vein
Hemiazygos vein
Posterior intercostals
Inferior vena cava
Ascending lumbar vein
Median antebrachial
vein
Cephalic vein
Basilic vein
Radial vein
Ulnar vein
Deep palmar venous arch
Superficial palmar venous arch
Digital veins
Anterior view
Inferior vena cava
(not part of hepatic
portal system)
Hepatic veins
Liver
Hepatic portal
vein
Small intestine
Gastric veins
Spleen
Inferior vena cava
Splenic vein
Right gastroepiploic
vein
Inferior
mesenteric vein
Superior
mesenteric vein
Large intestine
Rectum
The hepatic portal circulation.
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