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Integumentary System and Body Temperature Chapter 7 Integumentary System • Includes – Skin – Accessory structures (sweat glands, oil glands, hair and nails) – Subcutaneous tissue Functions of the Skin • Acts as a barrier- keeps harmful substances out and retains water and electrolytes • Protects internal structures from injury, chemicals, sunlight, burns and pathogenic microorganisms • Excretes water, salt and trace amounts of waste products (ex. urea) Functions of the Skin • Synthesizes vitamin D (from sunlight; necessary for the absorption of calcium from the digestive tract) • Contains sensory receptors for touch, pressure, pain, and temperature (helps detect information about the environment) • Important for regulation of body temperature Structure of the skin • Called integument (from the Latin word meaning “to cover”); also called cutaneous membrane • The largest organ in the body • Outer layer is the epidermis • Inner layer is the dermis • The dermis is anchored to the subcutaneous layer Epidermis • Thin outer layer of skin • Composed of stratified squamous epithelium • Avascular- receives oxygen and nutrients from the blood vessels of the dermis • The “dead layer” of the skin Epidermis • Stratum germinativum – Located on top of the dermis; has a rich blood supply – Cells are continuously dividing and producing millions of cells per day – New cells push older cells up toward the surface of the epithelium; as cells move away from the dermis they lose their blood supply and begin to die; these cells go through keratinization- keratin (tough protein) is deposited in the cell. Epidermis • Stratum germinativum – Keratin hardens and flattens the cells; makes the skin waterproof and provides protection • Stratum corneum – Surface layer of the epidermis – Composed of approx. 30 layer of dead, flattened, keratinized cells – Dead cells are continuously sloughed off; replaced by new cells moving up from the deeper layers; complete new skin every month FYI • Humans shed about 600,000 particles of skin every hour- about 1.5 pounds a year (that’s 105 lbs by the age 70!) This Bernese Mountain Dog weighs 105 lbs! Water loss • Approx. 500cc of water is lost every day through the skin • Insensible perspiration is sweat that evaporates from the skin before it is perceived as moisture on the skin; if the epidermis is damaged (as in burns) the rate of water loss through insensible perspiration increases tremendously Dermis • Located under the epidermis and composed of dense fibrous connective tissue • Contains collagen and elastin fibers surrounded by gel-like intercellular matrix (accounts for stretching of skin during pregnancy and weight gain) • The “living layer” of the skin Dermis • Thickness of the epidermis and the dermis varies according to location- thinnest at eyelids, thickest on palms and soles • Accessory structures (hair, nails, glands) are embedded in the dermis • Dermis contains blood vessels, nervous tissue (sensory receptors) and muscle tissue Subcutaneous Layer • Lies below the dermis • Not considered part of the skin; also called the hypodermis • Composed of loose connective and adipose tissue • Purpose: provided insulation and protects against extreme temperature change; anchors the skin to underlying structures Subcutaneous Layer • Drugs are often injected into the subcutaneous layer because it has a rich blood supply “Skin popping” heroin The skin, drugs and chemicals • The skin is capable of absorbing many chemicals- both medicines and dangerous chemicals • Transdermal (trans-) administration uses the skin to absorb drugs into the blood stream; allergy testing can be done using intradermal (intra-) injections Nitroglycerin patch The skin, drugs and chemicals • Toxins can also be absorbed through the skin; these include pesticides, cleaning chemicals, and poisons (remember anthrax?) Cutaneous anthrax Skin Color • Skin color is determined mostly by genetics, but also physiological factors and sometimes disease • Epidermal layer contains melanocytes; these cells secrete the skin darkening pigment melanin • The more melanin secreted, the darker the skin Skin Color • Everyone has roughly the same number of melanocytes • Differences in color occur because of the amount of melanin secreted • Exposure to UV rays increases the amount of melanin secreted (think tanning beds) Differences in skin color Malfunctioning Melanocytes • If melanocytes completely fail to secrete melanin, albinism occurs (people with the condition are called albinos) • Skin, hair and the iris of the eyes contain no pigment Malfunctioning Melanocytes • Vitiligo occurs when there is patchy loss of pigment in the skin Malfunctioning Melanocytes • Small areas of concentrated melanin are moles or freckles; moles that change appearance should be checked for melanoma (-oma tumor) Skin Color • Skin also contains a yellow color- carotene (most of the yellow color is usually hidden by the melanin) • Some skin appears to have a pinkish tint because there is so little melanin that the blood vessels of the dermis are visible • Lack of oxygen in these blood vessels causes cyanosis (cyano-); a bluish discoloration Cyanosis of the nailbeds Skin Color • Jaundice is a yellow discoloration of the skin and sclera resulting from an accumulation of bilirubin (usually from liver disease); newborns can also have jaundice Newborn with jaundice Bili lights used to treat newborn jaundice Skin Color • Argyria is a bluish-gray discoloration of the skin that results from an accumulation of colloidal silver in the skin (used to be found in cold and allergy medications as well as some skin creams- not FDA approved) Example of argyria Accessory Structures Hair • According to the text, the main function of hair is to sense insects on the skin before they sting • Hair also serves to conserve heat and insulate the body; provides some protection • Most of the body is covered with hairpalms, soles, lips, external reproductive organs Hair • Eyebrows and eye lashes protect the eyes from dust and perspiration • Nasal hairs and ear hairs trap dust and prevent it from entering the lungs Hair • Hair growth is regulated by testosterone and estrogen; the role of estrogen is not well understood. Testosterone stimulates hair growth; during puberty, the surge of hormones stimulates hair growth in the axillary and pubic areas Hair • Excessive testosterone in females causes hair growth in males patterns (facial hair, abdomen, hands etc.). This condition is called hirsutism Hair • Structure of the hair: – Shaft (visible part above the skin) – Root (part that extends from the dermis to the surface) – Follicle (downward extension of epithelial cells; opening in the skin that holds the hair) – Hair is formed in the same way as the outer layer of the skin; new cells are formed and are pushed to the outer layer- the cells die and become keratinized Hair • Hair color is determined by genetics- the amount and type of melanin; dark hair (lots of melanin), blonde hair (little melanin) white hair (no melanin), grey hair (mixture), red hair (melanin containing iron) Hair • The shape of the hair shaft determines the appearance of the hair- round shaft, straight hair; oval shaft, wavy hair; flat shaft, curly or kinky hair Hair • Hair helps to conserve body heat by “standing up” to trap a layer of air near the skin surface • Individual hairs are pulled perpendicular to the skin by tiny muscles called arrector pili which are attached to the hair follicle; the skin is pulled up slightly which creates “goosebumps” arrector pili Hair • Hair loss is called alopecia • The most common type of hair loss is male-pattern baldness (androgenic alopecia) Nails • Thin plates of stratified squamous epithelium that contains a very hard form of keratin • Found on the distal end of fingers and toes and serve to protect from injury Nails • Structure – Free edge – Nail body -Nail root -Lunula Nails • Nails appear pink because of blood vessels in the dermis • Clubbing of the nails occurs when there is an insufficient blood supply for a long period of time (often seen in long-time heavy smokers) Glands • Two major glands associated with the skin • Sebaceous glands (oil glands) – Associated with hair follicles; found on the body where there is hair – Secrete sebum lubricates and waterproofs – In the fetus, secretes vernix caseosa that covers the fetus and offers protection from amniotic fluid Glands • When accumulated sebum blocks a sebaceous gland and is exposed to air and dries out, it turns black and forms a blackhead. • If it becomes infected with staphylococci, it becomes a pustule, or a pimple Glands • Sudoriferous (sweat) glands – Located in the dermis, secrete sweat – Sweat is released through ducts that open onto the skin as pores – Two types: apocrine glands (associated with hair follicles and found in the axilla and pubic areas); eccrine glands (found all over the body, not associated with hair) Glands • Apocrine glands secrete sweat in response to emotional stress, fear, pain or sexual arousal – Causes body odor when sweat is broken down by bacteria on the skin surface • Eccrine glands secrete sweat in order to cool the body; as moisture evaporates, heat is lost – Mammary glands and ceruminous glands are modified sweat glands Body Temperature Body Temperature • Normal body temperature ranges from 97° to 100° (average is 98.6°F) • Fluctuates throughout the day, lower in the morning, higher in the afternoon • Core temp (cranial, thoracic & abdominal cavities) • Shell temp (skin and mouth) Body Temperature • Body temperature is maintained by balancing heat production and heat loss (remember homeostasis?) • This balance is known as thermoregulation • Excessive changes in body temperature can be severe, even fatal • Hyperthermia vs. hypothermia Heat Production • Heat is thermal energy • Produced by the millions of chemical reactions occurring in the body • The heat produced by metabolism is the basis for body temperature • At rest, most of the body’s heat is produced by the muscles, the liver and endocrine glands Heat Production • Heat production is affected by food consumption, hormone secretion and physical activity • Exercise greatly increases heat production; thyroid hormones influence heat production (thyroid storm can be lethal) Heat Loss • Most heat 80% is lost through the skin, the rest is lost through the respiratory tract and excretion of waste • Four means of heat loss – Radiation – Conduction – Convection – Evaporation Heat Loss • Radiation – Heat loss from warm object to surrounding air • Conduction – Heat loss from warm object to cooler object (contact); cooling blankets • Convection – Loss of heat due to air currents • Evaporation – Heat loss when liquid turns to gas (sweat on skin) radiation convection conduction evaporation Temperature Regulation • Thermostat of the body is the hypothalamus; senses changes in body temperature and sends information to the skin and skeletal muscle • Temperature elevation – Blood vessels dilate, allowing more blood to flow to the skin; this transfers heat from deeper tissues to the surface Temperature Regulation • Temperature elevation – Sweat glands are activated – When sweat evaporates from the skin, heat is lost • Temperature decrease – Blood vessels constrict, reducing blood flow to the skin; traps blood and heat in the deeper tissues – Sweat glands become less active – Shivering occurs, producing heat from muscle contractions Temperature Regulation • Intense heat can be dangerous to the body – Heat cramps – Heat exhaustion – Heat stroke (thermoregulatory failure) • Hypothermia slows metabolism and has been shown to improve patient outcomes in cardiac arrest (think cold-water drowning); but temps below 95° can be fatal Temperature Regulation • Thermoregulation is difficult for newborns – Large surface area increases heat loss – Thin layer of subcutaneous fat – Neonate cannot shiver • Neonates have brown adipose tissue (BAT) which produces a large amount heat when metabolized; this is called nonshivering thermogenesis Burns Burns • Classified according to depth of the burn and the extent of the surface area burned • Partial thickness – First degree (only epidermis involved) – Second degree (epidermis and dermis) • Full thickness (third degree) – Epidermis, dermis and underlying structures are destroyed Burns • First degree burns – Red, painful and slightly edematous Burns • Second degree burns – Redness, pain, edema, blisters Extensive burn with marked leakage (extravasation) of fluid into the burned area leading to formation of large blisters. Burns • Third degree burns – May appear brown, black or deep red; painless (area around the burn is very painful) Third Degree Burns Burns • Rule of Nines – Allows for estimation of body surface area affected by burn – Parkland formula is based on the rule of nines Fluid Requirements = TBSA burned(%) x Wt (kg) x 4mL Give 1/2 of total requirements in 1st 8 hours, then give 2nd half over next 16 hours. Burns • Eschar – Associated with severe burns – Dead, burned tissue that forms a thick, inflexible scar tissue layer over the burned area – Can act like a tourniquet and cut blood supply to an area, or can restrict breathing if on the chest – Can breed infection leading to deadly sepsis in the patient – Escharotomy is performed to release the tissue Eschar (decubitus ulcer on the heel) Approximate lines for chest escharotomy Burns Some disease and disorder terms… Normal skin changes associated with the aging process- loss of subcutaneous fat, thinning of dermis, transparent appearance of skin Decubitus Ulcers Staging Ulcers Stage 1 Stage 2 Skin red, intact Skin breakdown occurs Staging Ulcers Stage 3 Stage 4 Deeper than stage 2, extending into dermis and subcutaneous layers Severe tissue loss; muscle and bone may be involved Contact dermatitis Alopecia Aereata (patchy loss of hair) Alopecia totalis- total loss of scalp hair Alopecia universalis- complete loss of body hair (note lack of eye brows and eye lashes Furuncle: inflamed hair follicle, also called a boil Ecchymosis: fancy-schmancy word for bruise; technically, it is a superficial discoloration caused by blood in the tissue Ecchymosis Recurrent oral herpes caused by herpes virus type 1. Herpes Zoster (also called shingles) Shingles (affecting different branches of the trigeminal nerves CN V) Debridement- removal of damaged or necrotic tissue from a wound Keloid Scar (caused by excessive fibrosis) Branding (fraternity hazing) Scarification Cellulitis of the finger and face/ periorbital regions Eczema Eczema • A form of dermatitis, or inflammation of the epidermis. The term eczema is broadly applied to a range of persistent skin conditions. These include dryness and recurring skin rashes which are characterized by one or more of these symptoms: redness, skin edema (swelling), itching and dryness, crusting, flaking, blistering, cracking, oozing, or bleeding. Areas of temporary skin discoloration may appear and are sometimes due to healed lesions, although scarring is rare. In contrast to psoriasis, eczema is often likely to be found on the flexor aspect of joints. (from wikipedia) Psoriasis (red patches covered with silver scales) Psoriasis • • • Chronic, non-contagious autoimmune disease which affects the skin and joints. It commonly causes red scaly patches to appear on the skin. The scaly patches caused by psoriasis, called psoriatic plaques, are areas of inflammation and excessive skin production. Skin rapidly accumulates at these sites and takes on a silvery-white appearance. Plaques frequently occur on the skin of the elbows and knees, but can affect any area including the scalp and genitals. In contrast to eczema, psoriasis is more likely to be found on the extensor aspect of the joint. The disorder is a chronic recurring condition which varies in severity from minor localized patches to complete body coverage. Fingernails and toenails are frequently affected (psoriatic nail dystrophy) and can be seen as an isolated finding. Psoriasis can also cause inflammation of the joints, which is known as psoriatic arthritis. Ten to fifteen percent of people with psoriasis have psoriatic arthritis. The cause of psoriasis is not known, but it is believed to have a genetic component. Factors that may aggravate psoriasis include stress, withdrawal of systemic corticosteroid, excessive alcohol consumption, and smoking. There are many treatments available, but because of its chronic recurrent nature psoriasis is a challenge to treat (from wikipedia) Diaphoresis (excessive sweating) NCLEX Question: • 1. 2. 3. 4. A nurse is reading the physician’s progress notes in the client’s record and sees that the physician has documented “insensible fluid loss of approximately 800 mL daily”. The nurse understands that this type of fluid loss can occur through: the skin urinary output wound drainage the gastrointestinal tract Rationale • 1. Insensible loss of fluid occurs through the skin and the lungs. The person is not aware of these losses. NCLEX Question: • 1. 2. 3. 4. Which of the following would be the anticipated therapeutic outcome of an escharotomy procedure performed on a circumferential arm burn? The return of distal pulses Decreasing edema formation Brisk bleeding from the injury site The formation of granular tissue Rationale • 1. Escharotomies are performed to relieve pressure from the edema that accumulates under the inflexible eschar in a circumferential burn. This pressure can inhibit arterial circulation.