Survey
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Download Enzymes - Realmedia
Transcript
Overview of Ultraviolet Effects: Acute Damage Chronic Damage How is Asian/Chinese Skin different for photodamage? UV Pathways to Skin Damage Damaging effects are 80% UVB/20% UVA UVB Direct DNA damage UVA Inflammatory Mediators ROS generation Inflammatory Mediators UV Pathways to Skin Damage Damaging effects are 80% UVB/20% UVA Inflammatory Mediators Inflammatory Mediators UV Pathways to Skin Damage Damaging effects are 80% UVB/20% UVA Matrix-degrading enzymes (MMP, etc) Enzymes Matrix-degrading enzymes (MMP, etc) Enzymes UV Pathways to Skin Damage Damaging effects are 80% UVB/20% UVA Matrix-degrading enzymes (MMP, etc) Enzymes Matrix-degrading enzymes (MMP, etc) Enzymes UV Pathways to Skin Damage Damaging effects are 80% UVB/20% UVA Matrix-degrading enzymes (MMP, etc) Enzymes Both UVA and UVB both lead to chronic photodamage UVB UVA • Direct DNA damage – Immune suppression – Mutations and skin cancer • Reactive Oxygen Species Inflammation Pigmentation Metalloproteineases Collagen and elastin degradation Sagging, wrinkles Chinese women 14 – 20 years old Indian Chinese women14 14–– women 20years yearsold old 20 Chinese women 65 75 years old Indian women 65 75 years old How is Asian/Chinese Skin different for photodamage? • • • • • 1. 2. 3. Skin aging parameters start later than Caucasian1,2 with different patterns Within Chinese population, skin aging parameters start earlier for higher UV exposure by approximately 10 years1 Korean wrinkle formation is highly correlated with sun exposure3 Pigment changes are different in Asian skin versus Caucasian with aging and photoaging1 Photoaging differences are not all explained by differences in pigmentation Zhao, P. Wang C. Solar ultraviolet Radiation and Skin Damage: An epidemiological study among a Chinese popoulation. Archives of Environmental Health, 53:6, 1998. Chung, J.H. Photoaging in Asians. Photodermatology, Photoimmunology & Photomedicine. 19:109-121. 2003 Chung, J.H. Et al. Cutaneous Photodamage in Koreans. Archives of Dermatology 137:1043-1051. Photodamage is not just about pigmentation and wrinkles Photograph courtesy of Robert & Margaret Weiss, MD Effects of UV on Photoaging: Conclusions • UV exposure induces photodamage and photoaging through several mechanisms • UVA can produce photoaging in the absence of UVB • In order to reduce photodamage, sunscreens must protect against both UVB and UVA Photograph courtesy of Robert & Margaret Weiss, MD
