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[PO331] The assessment of efficacy and tolerability of cosmetics for acne-affected
skin.
Tazbir M.1, Vincent C.3, Dębowska R.3, Kaszuba A. 1,2, Kaszuba A.1,2 , Solyga-Zurek A.3,4, Eris I.3
1Department of Dermatology, Pediatric Dermatology and Oncology, Medical University of Lodz, Kniaziewicza 1/5, 91-347 Lodz, 2Specialist Medical Offices
„Dermed” in Lodz, Piotrkowska 48, 90-265, Lodz, 3Dr. Irena Eris Cosmetic Laboratories, Dr. Irena Eris Centre for Science and Research, Pulawska 107A, 02595 Warsaw, 4 Department of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, Pawinskiego 5a, 02-106 Warsaw.
Introduction
Acne vulgaris is a very common disease of sebaceous
glands concerning especially young people. The
etiopathology of acne is a very complex process which
involves four inter-related factors: increased sebum
excretion, hyperkeratinization of the pilosebaceous
units, ductal hypercolonization by Propionibacterium
acnes and inflammation.
Most adolescents (85%) develop mild physiological
acne [1] and this may respond to topical treatment. The
aim of the study was to determine the efficacy and
application qualities of the cosmetics (anti-acne face
cream, antibacterial face gel wash and micellar solution)
for acne-affected skin.
[1] Fitzpatrick T.B., Eisen A.Z., Wolf K., Fredbera I.M. Dermatology
in General Medicine. McGraw-Hill, New York, 1993: p. 709.
A dermatological assessment of the condition of the skin
was performed once every 4 weeks.
The assessment included:
• the evaluation of the intensity of the symptoms on the
Hellegren-Vincent scale, allowing the assessment of the
overall severity of major acne symptoms (erythema,
blackheads, pustules, inflammatory papules) (Table 1);
• estimation of the number of imperfections (papules,
pustules, blackheads);
• assessment of the level of seborrhea.
After 12 weeks, each patient completed a survey,
evaluating the quality of application and use of the
tested cosmetics.
Materials and Methods
Dermatologists conducted the study on a group of 80
people. The patients, divided into two 40-person groups,
tested the selected cosmetics every day for 12 weeks.
• in group A – a skin-care cream with piroctone olamine,
Tamarindus indica and Arctium majus extracts, with a
gel wash with mandelic acid and sodium salicylate;
• in group B – the skin-care cream and a micellar
solution with mandelic acid, burdock extract and biotin.
Table 1 - The scale of Hellegren and Vincent
Severity
Symptoms
I°
erythema, blackheads, 1-5 pustules or papules
II°
erythema, blackheads, 6-10 pustules or papules
III°
erythema, blackheads, 11-20 pustules or papules
IV°
erythema, blackheads, 21-30 pustules or papules
V°
erythema, blackheads, over 30 pustules or papules
[PO331] The assessment of efficacy and tolerability of cosmetics for acne-affected
skin.
Tazbir M.1, Vincent C.3, Dębowska R.3, Kaszuba A. 1,2, Kaszuba A.1,2 , Solyga-Zurek A.3,4, Eris I.3
1Department of Dermatology, Pediatric Dermatology and Oncology, Medical University of Lodz, Kniaziewicza 1/5, 91-347 Lodz, 2Specialist Medical Offices
„Dermed” in Lodz, Piotrkowska 48, 90-265, Lodz, 3Dr. Irena Eris Cosmetic Laboratories, Dr. Irena Eris Centre for Science and Research, Pulawska 107A, 02595 Warsaw, 4 Department of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, Pawinskiego 5a, 02-106 Warsaw.
Results (1)
1.a
Based on the results of the clinical
studies, it was concluded that all
tested products were safe in
application. There were only
several cases of mild skin irritation
(2 in group A and 6 in group B),
which involved mild skin redness
and/or increased scaling. All
irritation symptoms persisted for
maximum 4 days (in group B) and
all of the patients completed the
study.
During the 3-months observation, it
was shown that the tested products
were highly effective. Both groups
displayed an improvement in skin
condition (Fig. 1). A reduction in
severity of all acne symptoms,
according to the Hellgren-Vincent
scale, was noted for 25% (by 18%)
and for 35% (by 27%) of
all
patients in groups A and B,
respectively (Fig. 2).
2.a
1.b
2.b
Figure 1. Patients (1 – group A, 2 – group B)
before (a) and after the 90 day trial (b).
Figure 2. Changes in the intensity of acne
symptoms, Hellegren-Vincent scale [%].
Data average for all patients with reduction
in all acne symptoms, 25% and 35% of all
patients in groups A and B respectively.
[PO331] The assessment of efficacy and tolerability of cosmetics for acne-affected
skin.
Tazbir M.1, Vincent C.3, Dębowska R.3, Kaszuba A. 1,2, Kaszuba A.1,2 , Solyga-Zurek A.3,4, Eris I.3
1Department of Dermatology, Pediatric Dermatology and Oncology, Medical University of Lodz, Kniaziewicza 1/5, 91-347 Lodz, 2Specialist Medical Offices
„Dermed” in Lodz, Piotrkowska 48, 90-265, Lodz, 3Dr. Irena Eris Cosmetic Laboratories, Dr. Irena Eris Centre for Science and Research, Pulawska 107A, 02595 Warsaw, 4 Department of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, Pawinskiego 5a, 02-106 Warsaw.
Results (2)
During the 12 weeks test, the
level of seborrhea decreased
by 26% in group A (for 37,5%
of patients) and by 36% in
group B (for 50% of patients)
(Fig. 3), and the number of
pustules was reduced by 49%
in group A (for 45% of
patients) and by 62% in group
B (for 45% of patients) (Fig. 4).
The number of blackheads
decreased as well, by 33,7%
in group A (for 65% of
patients) and by 32,8% in
group B (for 40% of patients)
(Fig. 5).
For a great majority of
patients
an
antiinflammatory effect and a
reduction in the number of
inflammatory papules was
observed. The reduction was
50,5% in group A (for 87,5% of
patients) and 53,5% in group
B (for 90% of patients) (Fig.
6).
Figure 3. Changes in the severity of seborrhea.
Data average for all patients with improvement in
this aspect, 37.5% and 50% of all patients in
groups A and B respectively.
Figure 4. Changes in the number of pustules.
Data average for all patients with improvement in
this aspect, 45% of all patients in groups A and B.
Figure 5. Changes in the number of blackheads..
Data average for all patients with improvement in
this aspect, 65% and 40% of all patients in
groups A and B respectively.
Figure 6. Changes in the number of inflammatory
papules. Data average for all patients with
improvement in this aspect, 87.5% and 90% of all
patients in groups A and B respectively.
[PO331] The assessment of efficacy and tolerability of cosmetics for acne-affected
skin.
Tazbir M.1, Vincent C.3, Dębowska R.3, Kaszuba A. 1,2, Kaszuba A.1,2 , Solyga-Zurek A.3,4, Eris I.3
1Department of Dermatology, Pediatric Dermatology and Oncology, Medical University of Lodz, Kniaziewicza 1/5, 91-347 Lodz, 2Specialist Medical Offices
„Dermed” in Lodz, Piotrkowska 48, 90-265, Lodz, 3Dr. Irena Eris Cosmetic Laboratories, Dr. Irena Eris Centre for Science and Research, Pulawska 107A, 02595 Warsaw, 4 Department of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, Pawinskiego 5a, 02-106 Warsaw.
Results (3)
A clear majority of
the patients gave
high marks to the
quality of application
and use for the skin
care cream (Fig. 7).
Most patients also
evaluated positively
the efficacy and antiacne properties of
the formulation –
reduction in number
of papules and skin
imperfections, antishine
properties,
antibacterial
and
anti-inflamatory
activities (Fig. 8).
Figure 7.
Patients
assessing
positively
various
qualities of
the skincare day
cream (%
of all
patients
participating
in the
study).
Figure 8.
Patients
assessing
positively
the efficacy
of the skincare day
cream (%
of all
patients
participatin
g in the
study).
[PO331] The assessment of efficacy and tolerability of cosmetics for acne-affected
skin.
Tazbir M.1, Vincent C.3, Dębowska R.3, Kaszuba A. 1,2, Kaszuba A.1,2 , Solyga-Zurek A.3,4, Eris I.3
1Department of Dermatology, Pediatric Dermatology and Oncology, Medical University of Lodz, Kniaziewicza 1/5, 91-347 Lodz, 2Specialist Medical Offices
„Dermed” in Lodz, Piotrkowska 48, 90-265, Lodz, 3Dr. Irena Eris Cosmetic Laboratories, Dr. Irena Eris Centre for Science and Research, Pulawska 107A, 02595 Warsaw, 4 Department of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, Pawinskiego 5a, 02-106 Warsaw.
Results (4)
Both cleansing products were
also evaluated as effective
and
with
good
antiinflammatory and anti-acne
properties (Fig. 9 and 10). A
majority of the patients
participating in the study
declared, that they will to
continue usage the tested
products.
Conclusions
In both groups a significant
number of patients showed
a clear improvement in their
overall skin condition. The
tested cosmetics meet the
criteria for use by patients
with mild and average
symptoms of acne vulgaris,
and may be used to
supplement
pharmacological treatment.
Figure 9. Patients assessing
positively various qualities of the
face cleansing gel (% of all patients
participating in the study).
Figure
10
Patients
assessing
positively various qualities of the
micellar solution (% of all patients
participating in the study).