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Figure 5 Specific degeneration of histamine, MCH and hypocretin neurons in PD
Part a reprinted with permission from Elsevier Ltd © Shan, L. et al. Neuronal histamine production remains
unaltered in Parkinson’s disease despite the accumulation of Lewy bodies and Lewy neurites in the
tuberomamillary nucleus. Neurobiol. Aging 33, 1343–1344 (2012). Parts b and c adapted with permission from
Oxford University Press © Thannickal, T. C. et al. Hypocretin (orexin) cell loss in Parkinson’s disease. Brain 130,
1586–1595 (2007)
Shan, L. et al. (2015) Interactions of the histamine and hypocretin systems in CNS disorders
Nat. Rev. Neurol. doi:10.1038/nrneurol.2015.99
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