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New Unit: Neuroscience and Behavior “Everything psychological is simultaneously biological.” Our goals for this unit: Understand how the brain organizes and communicates within itself. Understand how heredity prewires the brain and how our experiences modify it. Brain, Body, and Behavior Brain Communication and the Glandular System Neural Communication-The Neuron Nerve cell that transmits electrical + chemical info through body. Body has 100 billion nerve cells that serve various roles. Each cell has short fibers called dendrites that receive info from nerve cells + send to axon. Axon is long fiber extending from cell body—carries message from cell to other neurons. Picture From: http://www.usm.maine.edu/psy/broida/101/neuron.JPG Cell body (Soma): neuron’s main cellular space Dendrites: receive messages from other neurons Axon: send messages to other neurons The Synapse Junction point of two or more neurons. Space between axon end and receiving dendrites. (less than one millionth of an inch) Neurons work on electricity, but won’t jump over space. The information cannot pass through without the aid of neurotransmitters. Neuron with Synapse Picture From: http://www.emc.maricopa.edu/faculty/farabee/BIOBK/neurons_1.gif Neurotransmitters Axon that ends before synapse have vesicles which contain neurotransmitters. Neurotransmitter = chemicals carry nerve signals across the synapse. 60 different neurotransmitters known Picture From: http://www.drugdigest.org/dd/images/anxcells.gif Neurotransmitters, cont’d… Acetylcholine (ACh): neurotransmitter which regulates bodily processes like muscular movement; most common neurotransmitter Botulism leads to decrease ACh release— results in paralysis. Venom of black widow leads to synaptic flood of ACh resulting in violent muscle contractions and convulsions. Neurotransmitters, cont’d… Dopamine – also used in bodily movement Influences movement, learning, attention, and emotion. Deficiency plays role in Parkinson’s and Alzheimer’s. Some substances can trigger production. Many drugs focus on releasing dopamine mimicking feelings. Adapted from Sadock, B.,& Sadock,V. 2003. Synopsis of Psychiatry. Philadelphia: LWW. More Neurotransmitters Serotonin – affects mood, hunger, sleep and arousal. Low Serotonin levels = depression SSRI’s (Selective Serotonin Reuptake Inhibitor) Paxil, Zolaft, Lexipro, etc. Serotonin is released from one nerve cell and passed to the next. In the process, some of the serotonin released is reabsorbed by the first nerve cell. (Reuptake) SSRIs block the reabsorption of serotonin into the first nerve cell. It is this blocking action that causes an increased amount of serotonin to become available at the next nerve cell. This is how SSRIs affect the balance of serotonin in the brain. More Neurotransmitters Norepinephrine- helps control alertness and arousal. More Neurotransmitters Endorphins (short for endogenous morphine). Associated with mood and pain. Explanation for “runners high”, also plays a role in painkilling.