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Comparison of disease progression in patients with colorectal cancer receiving vitamin C versus placebo. (Reproduced, with permission, from Moertel CG, Fleming TR, Creagan ET, Rubin J, O’Connell MJ, Ames MM: High-dose vitamin C versus placebo in the treatment of patients with advanced cancer who have had no prior chemotherapy: A randomized double-blind comparison. N Engl J Med 1985;312:137–141.) Source: Chapter 9. Analyzing Research Questions About Survival, Basic & Clinical Biostatistics, 4e Citation: Dawson B, Trapp RG. Basic & Clinical Biostatistics, 4e; 2004 Available at: http://mhmedical.com/ Accessed: April 29, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved