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Contents Chapter 1. Introduction 1 Chapter 2. Seroreactivity against Epstein-Barr Virus (EBV) 75 among First-degree Relatives of Sporadic EBV-associated Nasopharyngeal Carcinoma in Indonesia Journal of Medical Virology 2011, accepted Chapter 3. Epstein-Barr Virus (EBV) Serological Screening 91 Combined with EBV DNA Load in Nasopharyngeal Brushings for Early-stage Nasopharyngeal Carcinoma in Individuals with Chronic Head and Neck Complaints International Journal of Cancer 2011, submitted Chapter 4. Conserved Mutation of Epstein-Barr Virus Encoded109 BamHI-A Rightward Frame-1 (BARF1) Gene in Indonesian Nasopharyngeal Carcinoma Infectious Agents and Cancer 2010, Sept 19;5:16 Chapter 5. Purified Hexameric Epstein-Barr Virus-Encoded BARF1131 Protein for Measuring Anti-BARF1 Antibody Responses in Nasopharyngeal Carcinoma Patients Clinical and Vaccine Imunnology 2011, Feb 18:298-304 Chapter 6. Epigenetic Markers for Early Detection 147 of Nasopharyngeal Carcinoma in A High Risk Population Molecular Cancer 2011, May 2;10:48 Chapter 7. Development of A Non-invasive Method, Multiplex163 Methylation-specific PCR (MMSP) for Early Diagnosis of Nasopharyngeal Carcinoma Plos One 2011, submitted Chapter 8. General Discussion175 Summary193 Samenvatting Intisari Words of Gratitude213 Curriculum Vitae List of Publications viii