Download HERPESVIRIDAE

PAPOVAVIRIDAE
PETER H. RUSSELL, BVSc,
PhD, FRCPath, MRCVS
Department of Pathology and
Infectious Diseases, The Royal
Veterinary College,
Royal College Street,
London NW1 OTU.
E-mail
Web site
LEARNING OBJECTIVES
Students should be able to:
• Understand the different ways in which these viruses
cause transformation of epithelial cells;
• Appreciate that while most viruses are species
specific there is evidence that bovine virus 2 may
have a role in equine sarcoids;
• In cattle different viruses are associated with specific
sites e.g teat or alimentary tract; but even more
importantly some can become malignant by the
interaction of other co-factors.e.g. bracken, sunlight;
• There is promising experimental evidence that
vaccination using gene products will be successful.
This heterogeneous family of icosahedral
double stranded DNA viruses [45-55nm, 72
capsomeres]
originally
included
papillomaviruses, polyomaviruses and
vacuolating agents. Only the papilloma
viruses are of veterinary importance. The
DNA is unusual in that it has a circular
configuration and, lying independant of
chromosone DNA, is described as
episomal.
General properties
Transformation
There are several ways by which
papillomaviruses transform epithtelial
cells, but they all are initiated via the
early genes E5, E6, or E7.[1].
EQUINE
PAPILLOMAVIRUSES
EQUINE SARCOIDS
BOVINE
PAPILLOMAVIRUSES
BOVINE
PAPILLOMAVIRUSES
(cont.)
BOVINE
PAPILLOMAVIRUSES
(cont.)
CANINE PAPILLOMAVIRUS
RABBIT PAPILLOMAVIRUS
Further reading
1. Campo MS [1992] Cell transformation by
animal papillomaviruses. J gen Virol.73.217222.
2. Hayward MLR [1993].Filiform viral
squamous papillomas in sheep.
Vet.Rec.132.86-88.
3. Campo MS et al [1993] Prohylactic and
therapeutic vaccination against a mucosal
papillomavirus J gen Virol. 74. 945-953.