Download Diseases of Immunity

Chosen problems of
immunopathology
The physiologic function of the
immune system
is to protect individuals from infectious
pathogens.
Innate (natural, native) immunity .
Adaptive (acquired, specific) immunity.
Adaptive immunity may be:
1. cell-mediated (cellular)
2. humoral
Categories of immunopathology
Autoimmunity - immune response against
self-antigens.
Autoimmune disease.
Organ-specific autoimmune diseases
Systemic (generalized) autoimmune
diseases
Rheumatoid arthritis (RA)
Rheumatoid Arthritis
prevalence: 1% of the world’s population
sex: female > male (2-3:1)
age: 40 - 70
Rheumathoid Arthritis
Pathogenesis
Rheumatoid Arthritis
Morphological features
Rheumatoid Arthritis
Morphological features
Joints
Rheumatoid Arthritis
Morphological features
Skin
Rheumatoid Arthritis
Morphological features
Rheumatoid nodules
Rheumatoid Arthritis
Morphological features
Blood Vessels
Rheumatoid Arthritis
Morphological features
Blood Vessels
Rheumathoid Arthritis
Clinical features
Rheumathoid Arthritis
Clinical features
No specific laboratory tests are
diagnostic!
Rheumatoid factor in serum important,
but not present in all patients.
Rheumathoid Arthritis
Radiographic features
The diagnosis of RA
Rheumathoid Arthritis
Prognosis
Juvenile Rheumathoid Arthritis
Juvenile Rheumathoid Arthritis
Subtypes:
Juvenile Rheumathoid Arthritis
Pathogenesis
Polyarteritis nodosa
(Periarteritis nodosa)
Polyarteritis nodosa
Pathogenesis
Polyarteritis nodosa
Morphological features
Polyarteritis nodosa
Morphological features
Acute phase
Polyarteritis nodosa
Morphological features
Later phase
Polyarteritis nodosa
All stages of disease may coexist within
the same vessel and in different vessels!
Polyarteritis nodosa
Clinical features
Polyarteritis nodosa
Prognosis