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Transcript 
Coronary Phantom Design for
K-edge Angiography
John Jorgensen
Sarah Pachtman
Punam Patel
Marcus Spallek
Advisor: Dr. Frank Carroll
Project Background

Monochromatic tunable X-ray:

A simple process of arranging the head on collision of a
terawatt infrared laser and an electron beam from a particle
accelerator with picosecond timing
– Reduced radiation dose to patient
– Reduced contrast agent concentrations
• K-edge imaging
FOR MORE INFO...
Free Electron Laser Laboratory  http://www.vanderbilt.edu/fel/
Project Goals

Design a coronary phantom

Test contrast agent concentrations
– hypersensitivity reaction to iodine (3-12% patients)
– current clinical dilution is 1:16
– using monochromatic plain films it is possible to
see 1:256 dilutions

Determine optimal angle for stereo imaging
Tan θ = 3/30 = 0.10
3”
30”
θ
θ ~ 6°
Solution Description


Radio Translucent at
35 keV
Flexible material
– Fluid perfusion

Phantom Size
– 7.5cm diameter

Vasculature
– Size Range 5 - 0.5 mm
– Coronary arteries on
surface
– Curved channels
– Hollow vessels
Finger
imaged at
Finger
imaged at
19 keV
26 keV
Phantom Designs
Shelley Medical Imaging Technologies
www.simutech.com
Preliminary Sketch
Material - ReoFlex ™ Rubber

Physical Properties
• Flexible cured
product
• 2-component liquid
resin system
• Room-temperature
cure
• 20 Shore A
durometer
www.smooth-on.com
Schedule
Research
Material Testing
&
Design
Manufacturing
Testing
November
December
January
February
March
April
FOR MORE INFO...
http://vubme.vuse.vanderbilt.edu/srdesign/2003/group12/NCIIA
%20Grant%20Proposal.htm
Current Status

January
– On-track
• Material Selected
• Phantom Design Initiated
• Investigating Stereolithography as Possible
Manufacturing Method
– Behind
• Dosimetry Research
Future Plans
 February
– Have CAD prototype completed
– Find Suitable Manufacturing Company
– Start Manufacturing of Phantom
 March & April
– Test Dosimetry for Imaging
– Test for Optimal Stereo Angle
Team and Resources




Advisor: Dr. Frank Carroll, M.D.
Monochromatic x-ray machine
W.M. Keck Free-electron Laser (FEL) Center at Vanderbilt
University
Materials and tools provided by BME Department and FEL
Center
– Polyurethane resins from outside contractors
Photograph of device with laser cover removed
http://www.vanderbilt.edu/fel/Xray/manuscripts/final%20report%20for%20ONR%20grant%2020021218.doc
Questions?
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