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Indication and contra-indications for cardiac catheterization PUMCH Shen zhujun Cardiac catheterization For diagnosis • Left heart cath.(inclu. CAG) : from artery, use a catheter to measure left cardiac chamber and large vessel pressure or CAG or blood gas measurement. • Right heart cath. : from vein, use a catheter to measure the pressure, angiogram or blood gas sample, EP test or cardiac biopsy. Coronary angiogram For stable angina or ischemia without symptom • AP CCS III or IV on medication (B) • No matter the degree of AP, non-invasive test show high risk* (A) • Aborted cardiac death, sustained VT (≥30sec) or non-sustained (<30sec) polymorphic VT (B) High-risk CAD (annual death >3%) on non-invasive test • • • • Severe LV dysfunction rest (LVEF< 35%) High-risk on treadmill test (≤-11) Severe LV dysfunction on exertion (LVEF< 35%) Large area ischemic defect on stress test (esp. anterior wall, Dobutamine or the others) • Multiple ischemic segment on sress test For non-cardiac surgery assess the risk with know or suspect CAD • High risk with non-invasive test (C) • Angina refractory to medication (C) • Unstable angina, esp. moderate or high risk surgery (C) • Undetermined with non-invasive test with high risk clinical risk factors before high risk surgery (C) For valve patient • Adult valve patient with symptom need surgery or balloon therapy, non-invasive test suggest ischemia (B) • After middle age (male 45, female 50) with some risk factors without symptom before surgery (C) • Infective endocarditis with evidence of coronary embolism (C) For heart failure patient • CHF with systolic dysfunction with angina or segmental wall motion abnomality or any evidence of reversible ischemia (B) • Before heart transplantation (C) • CHF duo to MI with ventricular aneurysm or any mechanical complication (C) For STEMI --- indication I • Suitable for primary or rescue PCI– within 12 hrs or over 12 hrs with persistent ischemia, cathlab facility needed (A) • Cardiogenic shock need revascularization– 36 hrs from onset or 18 hrs after shock (A) • Complicated with VSD or severe MR need repair (B) • Complicated with persistent hemodynamic unstable or electrical unstable condition (C) For STEMI --- contra-indication III • Multiple co-morbidities, revascularization may not help the patient (C) For UA/STEMI --- indication • Recurrent ischemia after medication (B) • Moderate or High risk:TIMI score≥3. Age≥65yrs; ≥3 CAD risk factors; Known CAD; Aspirin in past 7 days; Recent (within 24hrs) severe angina; ST deviation≥0.5mm; cardiac markers elevation (A). • Low risk but non-invasive test show high risk: EF<0.35、large area ischemia (esp. anterior wall) or multiple segment ischemia (B) • UA post-PCI or CABG (C) • Prinzmetal angina (C) For UA/STEMI --- contraindication III • • • Multiple co-morbiditis, cannot benefit from revascularization (C) Chest pain with low risk UA (C) Not a candidate for revascularization (C) For recent MI --- indication • Any ischemic evidence on low level stress test (B) Relative contra-indication • Unknow fever or fever not controlled • Severe or acute liver or renal dysfunction or failure • Severe anemia • Severe electrolyte disturbance • End stage carcinoma • Aortic valve IE • Severe bleeding disease or active bleeding Relative contra-indication (Cont’) • • • • • • stroke (acute phase) Digoxin intoxication CHF not controlled Severe coagulation disease Patient can’t co-operate Any disease or condition make the patient can’t benefit from revascularization therapy Factors increase the risk of CAG • • • • • • • • • age> 70 yr Complicated congenital heart disease Severe obesity Cachexia Uncontrolled hyperglycemia Hypoxia Severe COPD CRF Hyperthyroidism Factors increase the risk of CAG (cont’) • • • • • • • • Triple vessel disease Left main disease Heart failure, grade IV Severe mitral valve 、aortic valve disease or after mechanical valve replacement LVEF< 35 % High risk on treadmill test (with hypotension or severe ischemia) Pulmonary hypertension PCWP> 25 mm Hg Factors increase the risk of CAG (cont’) • • • • • Coagulation or bleeding disturbance Uncontrolled hypertension Severe peripheral artery disease Recent stroke Severe aortic insufficency LV-gram indication • Routine LV-gram should be done before or after CAG to evaluate the left ventricular function, mitral valve and aortic valve function • LV was not done regularly in daily practice because the advantage of Echocardiography LV-gram Contra-indication • LV thrombus • Severe LV dysfunction, LVEDP≥20mmHg R-cath. Indication • Complicated congenital heart disease need anatomical and physiological assessment. • Congenital heart disease complicated with pulmonary hypertension • EP test • Cardiac biopsy R-cath. Contra-indication • Simple cases can be accurately diagnosed by echocardiography or other non-invasive procedures