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Comparative Vertebrate Physiology Cardiovascular systems in vertebrates Fish Heart anatomy Fish Blood flow pathway Amphibians Heart anatomy (spiral fold) Blood pathway (Spiral valve) Reptiles Heart anatomy Ventricle divided into 3 chambers Reptiles Blood flow pathway (non-crocodiles) Advantage during diving Reptiles Crocodiles Heart anatomy Foramen of Panizza Reptiles Blood flow pathway Advantage during diving Birds Heart anatomy Renal portal shunt Mammals Heart anatomy 4 chambers AV valves tricuspid, bicuspid Semilunar valves aortic, pulmonary Conduction pathway Myogenic pacemaker Conduction pathway Excitation sequence Heart rate fluctuations Sympathetic parasympathetic influence Pacemaker potential Cardiac action potentials Amplitude, configuration and duration of AP’s differ at different sites of the heart Refractory period Prolonged Refractory period Prolonged Ca++ and K+ permeability Ectopic pacemaker Extra heartbeat followed by a pause Electrocardiogram Ectopic pacemaker • Cause: AV node taking over role of damaged SA node Ectopic pacemaker • Cause: blockage of conductive pathway Cardiac cycle • Systole/diastole • Mid-to-late diastole • Atria and ventricles relaxed • Ventricles fill 80% • Aortic and pulmonary valves closed • SA node discharge • 20% filling of ventricles • EDV Cardiac cycle • Ventricular systole • QRS complex • First heart sound • Isometric pressure build up • Opening of aortic and pulmonary valves • ESV • Aortic pressure rises then falls • Atrial pressure rises Cardiac cycle • Early diastole • T wave • 2nd. Heart sound (closure of aortic and pulmonary valves, dicrotic notch) • AV valves open • Atria fill with blood Heart sounds • Lub • Caused by closure of AV valves • Onset of systole • Dub • Caused by closure of aortic and pulmonary valves • Onset of diastole