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Transcript 
The Complement Cascade
The Terminal Pathway
Complement: The Terminal Pathway
C3
C3a
C3b
C3b is the first component of the
Terminal Pathway
Complement: The Terminal Pathway
C3b
C5
C5b
C5a
C3b cleaves C5 producing C5a and C5b
Next
Complement: The Terminal Pathway
C5b
C6
C5b binds to C6
Complement: The Terminal Pathway
C5b.6
C5b binds to C6
Next
Complement: The Terminal Pathway
C5b.6
C7
C5b.6 binds to C7
Complement: The Terminal Pathway
C5b.6.7
C5b.6 binds to C7
Next
Complement: The Terminal Pathway
C5b.6.7
C8
C5b.6.7 binds to C8
Complement: The Terminal Pathway
C5b.6.7.8
C5b.6.7 binds to C8
Next
Complement: The Terminal Pathway
C5b.6.7.8
C9
C9
C9
C9
C9
C9
C9
C9
C9
C9
C9
C5b.6.7.8 binds 12-15 molecules of C9
to form the Membrane Attack Complex
Complement: The Terminal Pathway
C5b.6.7.8.9n
C5b.6.7.8 binds 12-15 molecules of C9
to form the Membrane Attack Complex
Next
Complement:
The Terminal Pathway
 The following slides are a graphical
illustration of the terminal pathway
 The end-point is the formation of the
membrane attack complex which punches a
hole in the bacterial membrane.
 This loss of membrane integrity results in
the death of the bacteria
• The graphics run automatically
Next
Complement: The Terminal Pathway
cell membrane
pathogen
Complement: The Terminal Pathway
C5b
Complement: The Terminal Pathway
C6
Complement: The Terminal Pathway
C7
Complement: The Terminal Pathway
Complement: The Terminal Pathway
C8
Complement: The Terminal Pathway
C9
Complement: The Terminal Pathway
Complement: The Terminal Pathway
Complement: The Terminal Pathway
Complement: The Terminal Pathway
Complement: The Terminal Pathway
Complement: The Terminal Pathway
Complement: The Terminal Pathway
Complement: The Terminal Pathway
Complement: The Terminal Pathway
Complement: The Terminal Pathway
Complement: The Terminal Pathway
Complement: The Terminal Pathway
Complement: The Terminal Pathway
Complement: The Terminal Pathway
End of Presentation
The Membrane Attack
Complex
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