Download interactions with other organisms

Dual Taxon Annotation
Amelia Ireland and Jane Lomax
Dual Taxon Annotation
• Annotation guide states
Taxon: taxonomic identifier(s)
 For cardinality 1, the ID of the species encoding the
gene product.
 For cardinality 2, the first ID is that of the species
encoding the gene product; the second ID is that of
the species using the gene product.
• Currently unused
Dual Taxon Annotation
• Suggest redefining as
 For cardinality 2, the first ID is that of the
species encoding the gene product; the
second ID is that of the species in which the
gene product is acting.
 Can be used for component or process terms
Dual Taxon Annotation
• Bacteria living as endosymbiont in plant
cell; secretes protein esp1 into host
cytoplasm
 Bacteria taxon 666
 Host taxon 123
• Annotation of esp1:
esp1
host cell cytoplasm
taxon:666|taxon:123
Dual Taxon Annotation
• Bacteria secretes protein bad1 which kills
the host cell
• Annotation:
bad1
killing of host cells
taxon:666|taxon:123
Dual Taxon Annotation
• Bacterial protein lig1 interacts with rec5
from bacteria of taxon 999, enabling them
to form a biofilm
• Annotation:
lig1
multi-species biofilm formation
taxon:666|taxon:999
rec1 multi-species biofilm formation
taxon:999|taxon:666
Dual Taxon Annotation
• Bacterial protein reg1 interacts with host
protein met3, regulating metabolic
processes in the host
reg1 regulation of metabolism in host
taxon:666|taxon:123
met3 regulation of metabolism by other organism
taxon:123|taxon:666
Dual Taxon Annotation
• Implementation:
 Ensure GO DB can store second taxon
 Enable display in AmiGO
 Amend annotation documentation
 Alter annotation tools
 Annotations correct without second taxon