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OMX PROBIOTICS
In 1908, Ellie Metchnikoff a nobel
laureate working at the Pasteur
Institute, discovered that ingestion of
certain microorganism can displace
putrefactive toxin-producing bacteria…
thus preventing (and even treating)
diseases, thereby prolonging life and
promoting health…
(this was noted among Bulgarian farmers)
For the last 20 years, Dr. Iichiroh
Ohhira a Japanese Microbiologist,
awarded “Scientist of the Year” in
1991 after successfully encapsulating
strains of good bacteria known as
“ Probiotics ”.
Super Infection
Develops due to the lost of inhibitory
influence of the intestinal microflora.
- The Pharmacological Basis of Therapeutics - (Goodman and Gilman)
Nosocomial Infection
- Associated after treatment of broad
spectrum antibiotics.
- The presence of large number of nonpathogenic bacteria provides protection
to the host by suppressing the growth of
potentially pathogenic bacteria.
- Principles of Surgery SWARTZ 7th edition.
OMX PROBIOTICS
Brand Name:
Origin, Founder:
OMX
Ohhira, Japan
Ingredients:
12 Strains of Lactobacillus and Bifidus
bacteria, 18 Essential and non-essential
amino acids, Vitamins B6, B12, folic acid,
niacinamide, panthothenic acid, biotin,
inositol, riboflavin, thiamine, Fe++, Ca, k+,
phosphorus, Na+.
Bacteria comprise 3.5 lbs
of our TBW.
30% of fecal material consist
of bacteria.
Thousands of billions of
bacteria resides in our
system.
INTESTINAL FLORA
10^7 bacteria
gram of saliva
10^4 jejunum
lactobacillus-enterococcus
10^3 stomachgastric acid
10^7 ileum mixed
flora
10^12/g ileo-cecal colon
bifidus bacteroids strep
MICROFLORA
85%
102 strains
Good Bacteria
15%
500 strains
Bad Bacteria
Beneficial
Friendly
Symbiotic
Harmful
Pathogenic
Opportunistic
BENEFICIAL FUNCTIONS
Prevent colonization and control
the growth of pathogenic bacteria
Strengthen immune system and
serve as body’s first line of
defense.
Produce ATP and vitamins k / BComplex and helps in the
digestion of food and
absorption of minerals.
BENEFICIAL FUNCTIONS
Guard against CANCER.
- Friendly bacteria neutralize & metabolize
procarcinogens & convert them back into
non-carcinogenic substances.
- Decrease the work load of the immune
system.
- Increase the activity of tumor killer cells
and DNA repair system.
“Probiotics” A Critical Review – Dr. Gerald W. Tannock 1999
“Probiotics” The Scientific Basis – Dr. Roy Fuller 1992
profoundly disturbs the
intestinal ecosystem
(1)
(2)
(3)
References:
1. Colombe JF et al. Lancet. 1987
2. Vanderhoof JA et al. J Pediatr. 1999
3. Goodman & Gillman. Pharmacological Basis of Therapeutics
A Probiotic should :




Be able to colonize the
gastrointestinal tract, even if for a
short time
Produce antimicrobial substances
Modulate immune responses
Influence human metabolic activities
Teitelbaum JE and Allan Walker W,
Int’l Seminars in Pediatr Gastroenterology and Nutrition
2002; 11.
OMX
Conditions Where Probiotics
Have Beneficial Effects





Lactose
Malabsorption
Prevention and
treatment of
Diarrhea
Constipation
Allergy
Pneumonia





OMX

Inflammatory
conditions (IBD,
NEC)
Cancer prevention
Cholesterol
Lowering properties
Prevention of liver
damage
Dengue
Immune
Enhancement
Mechanisms of Action







OMX
Acidification of gut lumen
Synthesis of antimicrobial substances
Competition for nutrients
Competition for receptors
Competitive inhibition of adhesion of
pathogen
Modification of toxins or toxin receptors
Stimulation of specific and non-specific
immune response.
Effect of OMX capsule on Diarrhea in infants
3-24 months of age
JRRMMC
Design
Randomized controlled trial. (2 Capsules a day)
Outcome
Intake of OMX Probiotics capsule (1capsule BID for 5 days),
in addition to ORS, significantly reduced the duration of
Diarrhea in children compared with those who only received
ORS. The mean days Were shorter 3.17 days in the probiotic
Group than in the non-probiotic group with 5.42 days.
* Second Prize; PPS – Inter-subspecialty Convention
2006, Manila
Presented: 1st Asian Congress of Pediatric Research
Tokyo, Japan 2006
Effect of OMX capsule as Adjunct in the treatment of
Severe Pneumonia in infants 6-24 months Of age
JRRMMC
Design
Randomized controlled trial Group 1 ampicillin & probiotics
Group 2 ampicillin only. (2 Capsules a day)
Outcome
Intake of OMX Probiotics capsule Significantly shortened the duration
of Illness (cough, fever, rales, retractions, Wheezing), hospital stay
and respiratory Symptoms with mean of 2.4 days in the Treatment
group vs. 4.3 days in the control Group. Increase of appetite was also
observed.
*First Prize; PPS – Inter-subspecialty Convention
2006, Manila
Presented: 3rd Asian Congress Pediatric Infectious
Disease, Bangkok, Thailand
2006
13th Pediatric Infectious Disease Society
Beneficial effects of probiotics, OMX capsule in
Grade II Dengue Hemorrhagic Fever
PCMC
Design
Randomized controlled trial Open label. (2 Capsules a day)
Outcome
Intake of OMX Probiotics capsule shows that patient did not
progress to further deterioration of their condition and were able to
have earlier normalization of their hematocrit and platelet count.
HCT 3.94 (control group) & 2.16 days (experimental group).
Platelet Count 5.50 (control group) & 3.3 Days (experimental
group).
Presented: 2nd Congress of Asian Pediatric Research,
Yokohama, Japan 2007
Effect of OMX Probiotic capsule on Immune
Markers of Undernourished Filipino Children
PCMC
Design
Randomized controlled trial Open label. (2 Capsules a day)
Outcome
Probiotics lead to significant weight gain (1 kilogram for
the first week) and shorter duration of infections.
Increase of appetite was also noted.
Presented: 25th International Congress of Pediatrics
Athens, Greece 2007
Effect of OMX, as adjunct treatment in Febrile
Neutropenia among children 2 – 18 years of age.
CSMC
Design
Double Blind Placebo Controlled Clinical Trial.
Outcome
OMX produced clinical reduction in mean body temperature,
shorter duration of hospital stay and significantly increase in
ANC count. Increase Appetite also was noted. With resolved
cases of UTI, mucositis and diarrhea.
* First Prize; 1.) CSMC Research Contest, 2008
2.) PSH&BT, September, 2008
Presented: Pediatric Academic Societies & 4th ASPR,
Honolulu, Hawaii, USA, 2009
OMX in the prevention of recurrent UTI in children
with Urinary Tract Abnormalities
PCMC
Design
Randomized Controlled Trial.
Outcome
OMX Probiotics prophylaxis was a s effective as
antibiotic prophylaxis in children with urinary tract
abnormalities; increase appetite was also noted.
* First Prize; 1.) PCMC - Research Contest, 2009
2.) PPS – Research Contest, April, 2009
Presented: Pediatric Academic Societies, 2009
Baltimore, Maryland, USA
Choosing the Right Probiotics
POWDERS
(free powders and capsules)
The freeze drying process involves the removal of water
by subjecting the bacteria to extremes of heat and cold
and the application of vacuum. This drastic “ripping off”
of water from a living organism disrupts its structure,
function and internal environment.
•
•
•
•
•
•
•
Addition of stabilizers and preservatives prior to freeze drying.
Severe bacterial cell damage occurs if centrifugation and chemicals are used.
Extensive damage to bacteria caused by freeze drying process.
Powder shelf life is short.
Powder absorbs water, then bacteria become activated and die away.
Live bacteria in the powder have damaged walls and cannot grow properly.
Transport and storage is easier, but must be refrigerated.
Choosing the Right Probiotics
LIQUID PREPARATIONS
(Yoghurt, etc.)
Liquid preparations offer major disadvantages which relate
to the instability of free organisms while in solution, harsh
methods of preparation such as pasteurization, and the
corrosive action of the stomach’s acid.
• Short shelf life (few organisms remain alive in solution after several weeks)
• Friendly bacteria damaged by pasteurization
(exposure to high temperatures 60 to 80 deg. C)
• Severe bacterial cell damage occurs if centrifugation and chemicals are used.
• Additives and preservatives are added to stabilize the bacteria in solution.
• Transport and storage is difficult.
• Not suitable for overseas travel.
Choosing the Right Probiotics
FERMENTED PASTE
CONTAINING
FRIENDLY BACTERIA
The preparation of OMX involves the use of
natural organic ingredients and a natural nonchemical fermentation process unlike any other
preparation process currently used by industry.
- Bacteria-functional and viable.
- No damage to bacterial cell wall.
- No centrifugation.
- No freezing.
- Storage and transport is easy.
- No preservatives and additives.
THANK YOU
WWW.RUCHEPHILS.COM
Roche P. Ruiz, MBA
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PROBIOTICS
It’s a Bacteria!!! GOOD Bacteria.
“Pro-bio” (Pro-Life)
A functional food medicine, which
beneficially improves and
restores, altered human Intestinal
Microbial Balance (IMB).
When taken a substantial amount offers
beneficial effect on the host. - WHO
ROYAL SOCIETY of MEDICINE of
GREAT BRITAIN reported the 90% of
ALL illnesses are caused by the
Infection of the GASTROINTESTINAL TRACT (GIT).
90% of ALL illnesses are associated
with BAD BACTERIA
meaning … “For Life"
It is the opposite of antibiotics or the
killing of bacteria.
Dr. Hippocrates (Father of Medicine) SAID
"Let your food be your medicine and
your medicine your food".
1941 Antimicrobial Therapy began with
the production of antibiotics called
penicillin.
This pharmaceutical agent become the
most misuse, abuse & over use.
Result of the widespread use of
antimicrobial agent has been the
emergence of antibiotics resistant
pathogen and “superinfection” (e.g.
pseudomembranous colitis – clostridium dificille)
GOODMAN & GILMAN
Lactose Intolerance:
digestive systems lack the enzymes to
break down lactose to simpler sugars.
Lactobacilli Bulgaricus:
It was discovered by?
Dr. Stamen Grigorov (Bulgaria 1905)
Lactobacilli Casei:
Now !!! Called
Lactobacilli Rhamnosus
also called sometimes L. GG (Gorbach and Golding)
Bacteria:
1. Resident
2. Transient
Bacterium Genes (Genus)
1. Lactobacilli
2. Bifidobacterium
3. Streptococcus 4. Enterococcus
Alkaline
Good Bacteria:
Acidic
means “MILK”
Lacto ?
Bad Bacteria:
Bacillus ?
Acidophilus
means “ROD-LIKE in SHAPE”
means “ACID-LOVING”
The large intestine houses the greatest number and
the widest assortment.
Lactobacillus Acidophilus
is the main bacteria that resides in the Small
Bowel.
Lactobacillus Bulgaricus
is a traveling bacteria that aids acidophilus and
bifidus.
Bifidus
is the main bacteria that resides in the COLON?
OMX PROBIOTICS
Brand Name:
Origin, Founder:
OMX
Ohhira, Japan
Ingredients:
12 Strains of Lactobacillus and Bifudus
bacteria, 18 Essential and non-essential
amino acids, Vitamins B6, B12, folic acid,
niacinamide, panthothenic acid, biotin,
inositol, riboflavin, thiamine, Fe++, Ca, k+,
phosphorus, Na+.
is a LIVE microbial food
medicine which beneficially
improves and maintain human
intestinal microbial balance.
Definition by the FAO/WHO
“live microorganisms which when
consumed in ADEQUATE
AMOUNTS, confer a health effect
on the host.
INTESTINAL FLORA
Group of
30% of feces are
bacteria inhabits
bacteria
the intestine
100 trillion
3.5 lbs TBW
bacteria of 400
are bacteria
different strains
BENEFICIAL FUNCTIONS
Prevent colonization and control
the growth of pathogenic bacteria
Strengthen immune system and
serve as body’s first line of
defense.
Produce ATP and vitamins k / BComplex and helps in the
digestion of food and
absorption of minerals.
Choosing the Right Probiotics
POWDERS
(free powders and capsules)
The freeze drying process involves the removal of water
by subjecting the bacteria to extremes of heat and cold
and the application of vacuum. This drastic “ripping off”
of water from a living organism disrupts its structure,
function and internal environment.
•
•
•
•
•
•
•
Addition of stabilizers and preservatives prior to freeze drying.
Severe bacterial cell damage occurs if centrifugation and chemicals are used.
Extensive damage to bacteria caused by freeze drying process.
Powder shelf life is short.
Powder absorbs water, then bacteria become activated and die away.
Live bacteria in the powder have damaged walls and cannot grow properly.
Transport and storage is easier, but must be refrigerated.
Choosing the Right Probiotics
LIQUID PREPARATIONS
(Yoghurt, etc.)
Liquid preparations offer major disadvantages which relate
to the instability of free organisms while in solution, harsh
methods of preparation such as pasteurization, and the
corrosive action of the stomach’s acid.
• Short shelf life (few organisms remain alive in solution after several weeks)
• Friendly bacteria damaged by pasteurization
(exposure to high temperatures 60 to 80 deg. C)
• Severe bacterial cell damage occurs if centrifugation and chemicals are used.
• Additives and preservatives are added to stabilize the bacteria in solution.
• Transport and storage is difficult.
• Not suitable for overseas travel.
Choosing the Right Probiotics
FERMENTED PASTE
CONTAINING
FRIENDLY BACTERIA
The preparation of OMX involves the use of
natural organic ingredients and a natural nonchemical fermentation process unlike any other
preparation process currently used by industry.
- Bacteria-functional and viable.
- No damage to bacterial cell wall.
- No centrifugation.
- No freezing.
- Storage and transport is easy.
- No preservatives and additives.
ANTIBIOTICS/CHEMOTHERAPY
RADIATION THERAPY
STRESSFUL LIFESTYLE
FOOD – HERBICIDES, PESTICIDES,
CHEMICAL, PRESEVATIVES
GASTRO-INTESTINAL DISORDER
Migraine Headache / Hypertension
- bad bacteria produce Tyramine.
- Tyramine triggers constriction of blood vessel.
Chronic Oral Ulcer
- Oral microbial balance destroyed by Antibiotics /
Steroids / Chlorinated water / Chemicals &
Pesticides – leads to depletion of Lactobacillus
Salivaricus (good bacteria)
Peptic Ulcer Disease
- Helicobacter Pylori – a pathogenic bacteria destroy the
mucosal lining of the stomach.
- acid can easily penetrate the eroded mucusa-producing
ulcer
Coronary Heart Disease
- Studies showed that DNA protein of chlamydia pneumonia
was found underneath the cholesterol plaque-atheroma of
coronary artery.
(British Journal of Cardiology)
Gall Bladder Stone
- E. Coli dis-conjugates bilirubin into insoluble bile. And
theis serves as a Nidus for stone formation.
Kidney Stone
-
Nano bacteria
Diabetes Mellitus
- E. coli toxins block the receptor site, which makes the
insulin inactive.
Alzheimer’s Disease
- E. coli bacteria forms fibers made up of amyloid, substance
that makes up the plaques that accumulate in the brain.
(Dr. Matthew R. Chapman – Washington University)
Hypertyroidisma
- Yersinia enterocolitica – a bad bacteria from intestine was
found in the thyroid gland of those patients suffering from
thyroid disease.
Chronic U.T.I.
- Depletion of Doderlie Bacillus.
- Imbalance of intestinal microbial flora may also lead to
chronic U.T.I. secondary to its anatomical proximity to the
anus.
Diarrhea
- Transient pathogenic bacteria from
contaminated food.
MECHANISM OF ACTIONS
* Acidification of Gut Lumen
* Synthesis of Antimicrobial substances
* Competition for Nutrients
* Competition for Receptors
* Competitive Inhibition of Adhesion of
Pathogen
* Modification of Toxins or Toxins Receptors
* Stimulation of Specific and Non-Specific
Immune Response
Some Local Trials/Evidences
on the Use of Probiotics
Acute Non-Bloody Diarrhea
Community Acquired Pneumonia
Allergy – Atopic Dermatitis
Nosocomial Infection
Dengue Hemorrhagic Fever Grade II
Immune Markers
for Undernourished
Febrile Nuetropenia
* Constipation
* CHRONIC U.T.I.
Acute Non-Bloody Diarrhea
Jose Reyes Memorial Medical Center
Intake of OMX Probiotics capsules (1 capsule BID for 5 days)
In addition to ORS, significantly reduced the duration of
Diarrhea in children compared with those who only received
ORS. The mean days were shorter 3.17 days in the probiotic
Group than in non-probiotic group with 5.12 days
Community acquired pneumonia
Jose Reyes Memorial Medical Center
Intake of OMX Probiotics capsules significantly shortened the
Duration of illness (cough, fever, rales, retractions, wheezing)
Hospital stay and respiratory symptoms with mean of 2.4 days
In the treatment group vs. 4.3 days in the control group.
(1-2 capsules 2x a day)
Allergy – atopic dermatitis
Jose Reyes Memorial Medical Center
Intake of Probiotics resulted to a lower score on the SCORAD
(SCORing Atopic Dermatitis) index, a clinical tool used to
Objectively assess atopic dermatitis. 46% less incidence with
Probiotics than 56% without.
Nosocomial infection
Philippine General Hospital
Preliminary results: Intake of Probiotic capsules prevent
nosocomial infection in Children with hematologic and
Oncologic Diseases.
Dengue Hemorrhagic Fever Grade II
Philippine Children Medical Center
Intake of OMX Probiotics did not progress to further deterioRation of their condition and were able to have normalization
of their Hematocrit and platelet count. HCT 3,94 (control
group) and 2.16 days (experimental group) Platelet Count 5.50
(control group) & 3.33 days (experimental group) 1-2 caps/days)
Immune Markers
for Undernourished
Philippine Children Medical Center
OMX Probiotics lead to weight gain and shorter
duration of infections.
Febrile Nuetropenia
Cardinal Santos Medical Center
* Constipation
Jose Reyes Memorial Medical Center
* Chronic u.t.i.
Philippine Children Medical Center
Summary
Proven Effects in (1)diarrhea,
(2)pneumonia, (3)dengue grade II,
(4)nosocomial infection, (5)allergy
prevention (6)Undernourished at least in
the local setting.

Cost-effective, safe as adjunct in the
routine treatment of common pediatric
conditions

Role in Illnesses
Role in Illnesses
Allergy is on the rise in industrialized nations. It
is estimated that the incidence of asthma in the
Philippines doubled between 1980 and 2000.
The hypothesis suggests that the exposure of infants
to microbes before the age of six months helps the
immune system mature to be more tolerant of
exposure to allergens later in life. Increasing exposure
to microbes must be done safely.
The effects of a Lactobacillus strain on incidence of
atopic eczema in 132 infants at high risk of
developing eczema.
Role in Illnesses
Role in Illnesses
Pregnant mothers two-to-four weeks before delivery
and newborn babies through six months of age were
given Lactobacillus rhamnosus GG.
Infants were followed through two years of age and
incidence of recurring atopic eczema was recorded.
The study reported a 50% drop in incidence of
recurring atopic eczema in the group receiving the
probiotic supplement.
Role in Illnesses
A follow up study of these same children indicated
that these same trends were still present at 4 years of
age. These results suggest that exposure to the right
types of microbes early in life may decrease the risk of
allergy.
Role in Illnesses
Elevated Blood Cholesterol.
Cholesterol is essential for many functions in the
human body. It acts as a precursor to certain
hormones and vitamins and it is a component of cell
membranes and nerve cells.
But, elevated levels of total blood cholesterol or other
blood lipids are considered risk factors for developing
coronary heart disease.
Role in Illnesses
Researchers found that the bacteria actually can
help control serum cholesterol in two ways.
First, as the bacteria grow in the intestinal tract,
they take up some of the cholesterol that is
present, and it becomes associated with the
cells as the bacteria grow.
Second, at least part of the cholesterol actually
becomes incorporated into the bacterial cells.
Either way, the cholesterol becomes unavailable
for absorption from the intestine into the blood.
Role in Illnesses
Probiotic cultures have been evaluated for their
effect on serum cholesterol levels.
Clinical studies on the effect of lowering cholesterol
or (LDL) low-density lipid levels in humans. There
have been human studies that suggest that blood
cholesterol levels can be reduced by consumption
of probiotic-containing dairy foods by people with
elevated blood cholesterol.
Role in Illnesses
Helicobacter pylori is a bacterium which
colonizes the stomach and can cause gastric ulcers
and gastric cancer. The effect of probiotics on H.
pylori has been studied. Mechanistic studies in
laboratory assays or in animal models have shown
that antibacterial substances including (but not
limited to) organic acids produced by some
lactobacilli inhibit the growth and survival of this
pathogen.
Results in humans suggest that some probiotic strains
or milk fermented with a probiotic strain can reduce
metabolic activity or colonization by H. pylori.
Role in Illnesses
Probiotics have also been used to manage side
effects of triple antibiotic therapy used to treat
Helicobacter pylori infections.
In these studies, the use of probiotics decreases the
side effects of antibiotics, improves patient
compliance with taking the prescribed therapy, and
increases the rate at which Helicobacter pylori is
eradicated (Lionetti et al. 2006; Myllyluoma et al. 2005; Sheu
et al. 2006; Sykora et al. 2005).
Role in Illnesses
Irritable bowel syndrome (IBS) is
a functional bowel disorder that can be characterized
by symptoms of abdominal pain, cramps, gas,
bloating, diarrhea and constipation. Surveys estimate
the prevalence rate ranging from 10-20% of the adult
population and the condition is diagnosed 3 times
more often in women than men (FDA Consumer
Magazine, July-Aug, 2001).
Role in Illnesses
It shows controlled studies that have been
conducted evaluating probiotics and IBS (RingelKulka T, Ringel Y. Probiotics in irritable bowel syndrome: has
the time arrived? Gastroenterology. 2007 Feb;132(2):813-6).
Some symptom relief (primarily from diarrhea or
abdominal pain or bloating) has been reported in
studies published to date (Whorwell PJ, Altringer L,
Morel J, Bond Y, Charbonneau D, O'Mahony L, Kiely B,
Shanahan F, Quigley EM. Efficacy of an encapsulated
probiotic Bifidobacterium infantis 35624 in women with
irritable bowel syndrome. Am J Gastroenterol. 2006
Jul;101(7):1581-90.).
Role in Illnesses
Inflammatory bowel diseases
such as “Ulcerative Colitis” and “Crohn’s
disease”, are serious intestinal diseases that can
lead to the surgical removal of the colon. The
cause of these diseases is not known but it has
been hypothesized that an intolerance to the
normal microbiota in the gut leads to
inflammation and resulting pathology. The role of
gut flora in the progression of these diseases has
led some researchers to study the impact certain
probiotic bacteria might have on maintaining the
state of reduced inflammation that occurs during
remission stages of the diseases.
Lactobacillus Acidophilus
Lactobacillus Acidophilus
This bacterium thrives in more acidic environments
than most related microorganisms (pH 4-5 or lower)
and grows best at 45 degrees Celsius.
Lactobacillus acidophilus occurs naturally in
the human intestine, mouth, and vagina.
Lactobacillus acidophilus ferments lactose into
lactic acid. Lactobacillus acidophilus itself (a
homofermentative microorganism) produces only lactic
acid.
Like many bacteria, Lactobacillus acidophilus
can be killed by excess heat, moisture, or direct
sunlight.
Lactobacillus Bulgaricus
Lactobacillus Bulgaricus
Lactobacillus bulgaricus is one of several
bacteria used for the production of yogurt. First
identified in 1905 by the Bulgarian Dr. Stamen
Grigorov, it is named after Bulgaria.
The bacterium feeds on milk and produces lactic
acid which also helps to preserve the milk. It breaks
down lactose and is often helpful to sufferers of
lactose. While fermenting milk, Lactobacillus
bulgaricus produces acetaldehyde, which perfumes
yogurt. Some of the biggest importers of the
bacterium are Japan, USA and the EU.
Lactobacillus Rhamnosus
Lactobacillus Rhamnosus
Lactobacillus casei is a transient, anaerobic
microorganism of genus Lactobacillus found in
the human intestine and mouth. As a lactic acid
producer, it has been found to assist in the
propagation of desirable bacteria. This
particular species of lactobacillus is
documented to have a wide pH and temperature
range, and complements the growth of
Lactobacillus acidophilus, a producer of the
enzyme amylase (a carbohydrate-digesting enzyme).
It is known to improve digestion and
reduce milk intolerance and constipation.
Lactobacillus Helveticus
Lactobacillus Helveticus
Lactobacillus helveticus is a homofermentative
thermophilic lactic acid bacterium. Our data
contribute to the description of microbial
heterogeneity in Lactobacillus helveticus and
provide a more solid basis for understanding the
functional and ecological significance of the
presence of different Lactobacillus helveticus
biotypes in natural dairy starter cultures.
This bacterium works as a support in all the
group and it has significantly powerful in
terms of assistance.
Lactobacillus Fermentum
Bifidobacterium Longum
Lactobacillus Fermentum
Lactobacillus fermentum was selected for further
study, since, in addition to its intrinsically high
adhesion rate, this organism was found to
exhibit a “preferential binding” to the follicleassociated epithelium of the Peyer's patches
compared with its level of binding to the mucussecreting regions of the small intestine.
Kulani
Lactobacillus Plantarum
Lactobacillus Plantarum
Lactobacillus plantarum is a widespread member
of the genus Lactobacillus. It is in saliva (from which
it was first isolated).
It has the ability to liquefy gelatin.
Lactobacillus plantarum has one of the largest
genomes known among the lactic acid bacteria
and is a very flexible and versatile species.
Bifidobacterium Bifidus
Bifidobacterium Bifidus
Bifidus (Bifodobacterium bifidum) lowers the pH
of the intestine, manufactures specific B
vitamins, promotes immune function, and
supports the health of the large intestine (colon).
Bifidus is a natural inhabitant of the large intestine
that helps with the absorption of water from food
and the processing of remaining waste.
Good intestinal flora in the large intestine
can help inhibit gas and bloating.
Bifidobacterium Infantis
Bifidobacterium Longum
Scientists have sequenced the genome of one of the
most important residents in the human
gastrointestinal tract, a bacterium that keeps the
digestive system running smoothly, blocks the
growth of harmful bacteria, and boosts the immune
system. The microbe, called Bifidobacterium longum,
is often the dominant bacterium found in humans.
Bifidobacterium Breve
Bifidobacterium Breve
Bifidobacteria are natural inhabitants of the
human gut microbiota, representing up to 91% of
the total gut population in breast-fed babies.
Some strains of the genus Bifidobacterium are
considered probiotics and can exert several
health-promoting effects. Bifidobacterium breve is
one of the species more often found in infants.
The intestinal microbiota is continuously exposed
to cytotoxic agents, including antibiotics. Recent
evidence indicates that Bifidobacterium breve is
generally more resistant to antibiotics than other
Bifidobacterium species
Bifidobacterium Lactis
Bifidobacterium Lactis
Effects of Bifidobacterium lactis Bb12
Supplementation on Intestinal Microbiota of Preterm
Infants: a Double-Blind, Placebo-Controlled,
Randomized Study. J Clin Microbiol. 2006 November; 44(11):
4025–4031.
Streptococcus Thermophilus
Streptococcus Thermophilus
Streptococcus thermophilus (official name Streptococcus
salivarius subsp. thermophilus). It is also classified as a
lactic acid bacterium (LAB). Streptococcus
thermophilus is found in milk and milk products. (it
does not survive the stomach) and generally used in the
production of yogurt.
THERAPEUTIC USES
Restore improves and maintain the intestinal
microbial balance , after antibiotics, chemotherapy,
radiotherapy and other factors that alter the
Intestinal flora.
“One (1) to three (3) capsule per day”
Antibiotics you need more Probiotics.
Why? Along with killing the pathogenic bacteria, antibiotic destroy
The balance by destroying good bacteria in your digestive system. “Ideally,
you should start repopulating your digestive system with good bacteriaprobiotics when you begin your course of antibiotics.”
BACTERIA
TYPE
SOURCE
ANTIBIOTIC(S)
PRODUCED
BIFIDOBACTERIUM
BIFIDUM
RESIDENT
BIFIDO-ENRICHED
MILK
SUPPLEMENTS
BIFIDIN
LACTOBACILLUS
ACIDOPHILUS
RESIDENT
ADIDOPHILLUS
ENRICHED MILK
SUPPLEMENTS
ACIDOLIN,
ACIDOPHILIN,
LACTOBACILLIN,
LACTOCIDIN
LACTOBACILLUS
BREVIS
TRANSIENT
MILK, KEFIR,
CHEESE,
SAUERKRAUT
LACTOBREVIN
LACTOBACILLUS
BULGARICUS
TRANSIENT
YOGURT, CHEESE
SUPPLEMENTS
BULGARICAN
STRETOCOCCUS
LACTIS
TRANSIENT
RAW MILK RAW
MILK PRODUCTS,
CHEESE, COTTAGE
CHEESE,
BUTTERMILK
NISIN