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Virus Video
http://www.youtube.com/watch?v=Rpj0emEGShQ
Viruses & Bacteria can cause infection
• Pathogen - Any disease-causing agent
1 nanometer (nm) = one
billionth of a meter
100 nm
eukaryotics cells
10,000-100,000 nm
viruses
50-200 nm
prokaryotics cells
200-10,000 nm
viroids
5-150 nm
prion
2-10 nm
Virus
• 2 basic parts:
– protein coat.
– Contains DNA or RNA
• non-living pathogen
• Viruses have a simple structure.
enveloped
(influenza)
capsid
helical
(rabies)
nucleic acid
lipid
envelope
polyhedral
(foot-and-mouth
disease)
Surface proteins
capsid
nucleic acid
surface
proteins
lipid envelope
surface
proteins
capsid
nucleic acid
All viruses have two main parts:
1. DNA or RNA – genetic info
2. Capsid – a protein coat
Bacteriophages: viruses that infect bacteria.
capsid
DNA
tail sheath
tail fiber
• Viruses enter cells in various ways.
– bacteriophages pierce host cells
colored SEM; magnifications:
large photo 25,000; inset 38,000x
Virus inserting it’s DNA into a bacterial cell.
Viral Replication Picture
http://glencoe.mcgrawhill.com/sites/9834092339/student_view0/chapter28/life_cycle
_of_t2_phage.html
http://www.mcgrawhill.ca/school/schoolGraphics
/biology2_1.mpg
• Viruses enter cells in various ways.
– Endocytosis (pulled into cell)
• Viruses enter cells in various ways.
– fuse with membrane
Viruses contain DNA/RNA, proteins, and they reproduce…
Are viruses alive???
NO.
They contain no nucleus, cytoplasm, organelles or cell
membrane; they cannot carry out cell functions, and they can
only “reproduce” when an infected cell builds new viruses.
Grouping Viruses
• Grouped according to:
– Presence of Capsid and envelope – shape
– RNA or DNA, single or double stranded – structure
Viral Group
Nucleic Acid
Shape and Structure
Example
Papovaviruses
DNA
Icosahedral, non-env.
Warts, cancer
Adenoviruses
DNA
Icosahedral, non-env.
Resp. & intestinal
infections
Herpesviruses
DNA
Icosahedral, enveloped
Herpes simplex,
chicken pox, mono,
shingles
Poxviruses
DNA
Complex brick, enveloped
Small pox, cow pox
Picornaviruses
RNA
Icosahedral, non-env.
Polio, hepatitis, cancer
Myxoviruses
RNA
Helical, enveloped
Influenza A, B, C
Rhabdoviruses
RNA
Helical, enveloped
Rabies
Retroviruses
RNA
Icosahedral, enveloped
AIDS, cancer
Treatment and Prevention
Anti-viral drugs:
interfere with viral DNA/RNA
synthesis
Vaccines – creates antibodies
Inactivatedthe virus is “dead”; cannot replicate
Attenuated-
the virus has been genetically
altered; still functional, but won’t
cause disease
Attenuated tend to be more effective vaccines
Some Pictures are Graphic
The Lysogenic Cycle
When viruses remain inactive within host cells
for days, months or years.
•Viral DNA inserted directly into the
host DNA.
•Viral DNA copied with host DNA during
replication
•Viral DNA passed on to daughter cells
during mitosis
•Remains dormant (no viral proteins are
produced) until some “triggering event”
Examples: Chickenpox
and Shingles; HIV
Stress
chemicals
UV light
???
heat
POXVIRUSES
Small Pox
BACK
PICORNAVIRUSES - Polio
BACK
Destroys the motor
neurons that are
producing the virus.
The result is a loss of
muscle control including
the diaphragm. The
iron lung changes the
pressure to pump air in
and out of the lungs.
U.S.
President
Franklin
Delano
Roosevelt
MYXOVIRUSES
Flu Virus
BACK
RHABDOVIRUSES
Rabies
BACK
RETROVIRUSES
Herpes
HPV Tree man
Ebola
Syphilis
• Sketch & Label the following:
T4 Bacteriophages
capsid
DNA
tail sheath
tail fiber
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