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Biomedical Technology Cellular Biology and Cancer Objective 3 Genetic damage and mutation Genetic Damage Question: What exactly is damaged when genetic damage occurs? Answer: The genes in the normal cells are damaged. Cancer results from the accumulation of genetic damage to cells across time. Cancer Cells vs. Normal Cells Question: How are cancer cells different from normal cells? Answer: 1. Shape changes 2. Changes in their dependence on growth factors 3. Multitude of biochemical differences Cancer is a Multi-Step Process Question: What are three cancer facts that support the theory that cancer is a multi-step process? Answer: 1. Increased incidence of cancer with age 2. Development of cancer decades after exposure 3. Increased incidence of cancer among people with inherited dispositions