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ADVANCES IN SURGERY Samuel Vincent G. Yrastorza, MD, FPUA DIAGNOSTICS Has grown leaps and bounds for the past years Symptomatic disease - history and PE still accounts for 80-90% in clinching the diagnosis Asymptomatic diseases - screening procedures detect early diseases - e.g. colonoscopy for colon cancer DIAGNOSTIC ADVANCES Before Signs and Symptoms + PE Abdominal pain, Diarrhea PE = abdominal mass Diagnostic Exam/Imaging Stool exam Colonoscopy, Abdominal CT scan Diagnosis Colonic Cancer DIAGNOSTIC ADVANCES Presently Reaching 40 y/o Screening Colonoscopy Colonic Cancer Without any signs or symptoms of disease Small colonic mass noted and biopsy done DIAGNOSTIC ADVANCES CT Scan - Has become more sensitive and specific - Diagnostic modality of choice for a majority of surgical cases with the advent of - 3D reconstruction - CT angiography DIAGNOSTIC ADVANCES CT Scan prototype EMI CT scan 256 slice CT scan IMAGING CT before 256 slice with 3D reconstruction COLON IMAGING Colonoscopy 256 slice with 3D reconstruction IMAGING CT before 128 slice with 3D reconstruction KIDNEYS IMAGING Conventional angiogram CT angiogram Radiotherapy Brachytherapy - Greek brachy meaning “short” - radioactive source placed inside or next to the area of treatment - not just for adjunctive therapy or pallation - as first line treatment for various forms of cancer - commonly used for prostate cancer, cervical cancer , head and neck cancer - radioactive sources - strontium plaque - iridium wires - iodine 125 seeds PROSTATE BRACHYTHERAPY PROSTATE BRACHYTHERAPY PROSTATE BRACHYTHERAPY - for early and localized cancer - not for locally advanced or metastatic prostate cancer - comparable result to radical prostatectomy - out patient procedure - lesser complications than radical prostatectomy - uses iodine 125 seeds LOCALIZED PROSTATE CA TREATMENT brachytherapy Radical prostatectomy CRYOTHERAPY Probes/needles directed at organ or tissue Freezing ---- thawing---- freezing cellular disruption cell death CRYOTHERAPY Used for - benign and malignant skin conditions - early and localized cancers - liver - prostate - hemorrhoids CRYOTHERAPY Used for - benign and malignant skin conditions - early and localized cancers - liver - prostate (widespread use) - hemorrhoids CRYOTHERAPY ice balls RADIOFREQUENCY ABLATION RFA probe (needle) placed inside the tumor (guided by CT scan or ultrasound or through open procedures) Radiofrequency waves passed through probe into tumor increased in temperature within tumor tumor necrosis RADIOFREQUENCY ABLATION Indications - tumors of the lung, liver, bone - used for primary and metastatic tumors - recurrent atrial fibrillation and supraventricular tachycardia - varicose veins RADIOFREQUENCY ABLATION RFA probe (needle) RFA generator RADIOFREQUENCY ABLATION RADIOFREQUENCY ABLATION Percutaneous approach Laparoscopic approach Open approach HIGH INTENSITY FOCUS ULTRASOUND (HIFU) HIFU directed at tissue/tumor (by ultrasound or MRI) increase temperature at target tissue/tumor tissue/tumor destruction HIGH INTENSITY FOCUS ULTRASOUND (HIFU) used for: - uterine fibroids - solid tumor of the brain, bone, breast, liver, pancreas, rectum, kidney, testes, prostate - earliest and widest use = for prostate cancer - atrial fibrillation, arrhythmia HIGH INTENSITY FOCUS ULTRASOUND (HIFU) SURGICAL PROCEDURES - Trend toward less invasive procedures The “old way” NOW LAPAROSCOPIC SURGERY - Minimally invasive surgery Minimal access surgery Key hole surgery Pinhole surgery Band-aid surgery *** part of a broader field of ENDOSCOPY LAPAROSCOPIC SURGERY Access LAPAROSCOPIC SURGERY Used for: - diagnostic - cancer surgery - donor organ harvest ( donor nephrectomy) - vascular surgeries - practically any abdominal surgery LAPAROSCOPIC SURGERY Advantages - smaller incisions (smaller scars) - fast recovery (short hospital stay) - better visualization of abdminal structures LAPAROSCOPIC SURGERY Disadvantages - more expensive - requires expertise - steep learning curve - longer operating time (gap is slowly closing with that of open surgery) ARTHROSCOPIC SURGERY - Cystoscopic surgery of the joints - Similar advantages and disadvantages as laparoscopy arthroscopic Open Knee surgery THORACOSCOPIC SURGERY - Cystoscopic surgery of the THORAX - Similar advantages and disadvantages as laparoscopy - Instruments basically the same Open thoracic surgery thoracoscopic Others Cranioscopy??? Not enough space Microlaparoscopy - 3mm port instead of the usual 5 and 10 mm ports - Smaller instruments - Lesser pain and scar ROBOTIC SURGERY ROBOTIC SURGERY ROBOTIC SURGERY ROBOTIC SURGERY ROBOTIC SURGERY Telementoring - Teaching/mentoring through the internet - “out of school students” - Open universities Telementoring Telementoring - Surgical training though internet or other forms of telecommunications Telesurgery Stem Cell Therapy - Use of stem cells to treat certain diseases - To create new tissues/organs to replace/augment the existing ones Stem Cell Therapy - Use of stem cells to treat certain diseases - To create new tissues/organs to replace/augment the existing ones DM type 1 New pancreatic cells transplanted into patient Stem Cell Therapy Stem cells - unspecialized cells capable of renewing themselves through cell division - can be induced to become tissue or organ specific cells - in gut and bone marrow = stem cells regularly divide to repair and replace worn out or damages tissues - pancreas and heart = stem cells divide only under special conditions Stem Cell Therapy Categories 1) Non embryonic - somatic or adult stem cell 2) Embryonic - use of human embryo Stem Cell Therapy Non embryonic e.g. Bone Marrow transplant - for luekemia - replacing the old marrow with new Bone Marrow - new marrow will produce new and normal blood cells (leukocytes, macrophages etc) Stem Cell Therapy Embryonic Stem Cell Therapy The Promise of stem cells 1) Understanding the development of specialized cells and eventually the evolution of diseases 2) Possibility of renewable source of replacement cells and tissues to treat diseases What Else? Penile Transplant???!! END