Download Cancer

Cancer
• Cancer- a malignant tumor;
the result of abnormal cell
proliferation.
• Regulation of Cell Division
– Tumor Supressor Genes
• Genes that inhibit cell division.
– Proto-Oncogenes
• Genes that promote cell
division.
p53 Tumor Suppresor Gene
DNA Repair is Successful
DNA Repair is Unsuccessful
Apoptosis Successful
p53 Tumor Suppresor Gene
p53 Gene
•
ACTTGTCATGGCGACTGTCCAGCTTTGTGCCAGGAGCCTCGCAGGGGTTGATGGGATTGGGGTTTTCCCC
TCCCATGTGCTCAAGACTGGCGCTAAAAGTTTTGAGCTTCTCAAAAGTCTAGAGCCACCGTCCAGGGAGC
AGGTAGCTGCTGGGCTCCGGGGACACTTTGCGTTCGGGCTGGGAGCGTGCTTTCCACGACGGTGACACGC
TTCCCTGGATTGGCAGCCAGACTGCCTTCCGGGTCACTGCCATGGAGGAGCCGCAGTCAGATCCTAGCGT
CGAGCCCCCTCTGAGTCAGGAAACATTTTCAGACCTATGGAAACTACTTCCTGAAAACAACGTTCTGTCC
CCCTTGCCGTCCCAAGCAATGGATGATTTGATGCTGTCCCCGGACGATATTGAACAATGGTTCACTGAAG
ACCCAGGTCCAGATGAAGCTCCCAGAATGCCAGAGGCTGCTCCCCGCGTGGCCCCTGCACCAGCAGCTCC
TACACCGGCGGCCCCTGCACCAGCCCCCTCCTGGCCCCTGTCATCTTCTGTCCCTTCCCAGAAAACCTAC
CAGGGCAGCTACGGTTTCCGTCTGGGCTTCTTGCATTCTGGGACAGCCAAGTCTGTGACTTGCACGTACT
CCCCTGCCCTCAACAAGATGTTTTGCCAACTGGCCAAGACCTGCCCTGTGCAGCTGTGGGTTGATTCCAC
ACCCCCGCCCGGCACCCGCGTCCGCGCCATGGCCATCTACAAGCAGTCACAGCACATGACGGAGGTTGTG
AGGCGCTGCCCCCACCATGAGCGCTGCTCAGATAGCGATGGTCTGGCCCCTCCTCAGCATCTTATCCGAG
TGGAAGGAAATTTGCGTGTGGAGTATTTGGATGACAGAAACACTTTTCGACATAGTGTGGTGGTGCCCTA
TGAGCCGCCTGAGGTTGGCTCTGACTGTACCACCATCCACTACAACTACATGTGTAACAGTTCCTGCATG
GGCGGCATGAACCGGAGGCCCATCCTCACCATCATCACACTGGAAGACTCCAGTGGTAATCTACTGGGAC
GGAACAGCTTTGAGGTGCGTGTTTGTGCCTGTCCTGGGAGAGACCGGCGCACAGAGGAAGAGAATCTCCG
CAAGAAAGGGGAGCCTCACCACGAGCTGCCCCCAGGGAGCACTAAGCGAGCACTGCCCAACAACACCAGC
TCCTCTCCCCAGCCAAAGAAGAAACCACTGGATGGAGAATATTTCACCCTTCAGATCCGTGGGCGTGAGC
GCTTCGAGATGTTCCGAGAGCTGAATGAGGCCTTGGAACTCAAGGATGCCCAGGCTGGGAAGGAGCCAGG
GGGGAGCAGGGCTCACTCCAGCCACCTGAAGTCCAAAAAGGGTCAGTCTACCTCCCGCCATAAAAAACTC
ATGTTCAAGACAGAAGGGCCTGACTCAGACTGACATTCTCCACTTCTTGTTCCCCACTGACAGCCTCCCA
CCCCCATCTCTCCCTCCCCTGCCATTTTGGGTTTTGGGTCTTTGAACCCTTGCTTGCAATAGGTGTGCGT
CAGAAGCACCCAGGACTTCCATTTGCTTTGTCCCGGGGCTCCACTGAACAAGTTGGCCTGCACTGGTGTT
TTGTTGTGGGGAGGAGGATGGGGAGTAGGACATACCAGCTTAGATTTTAAGGTTTTTACTGTGAGGGATG
TTTGGGAGATGTAAGAAATGTTCTTGCAGTTAAGGGTTAGTTTACAATCAGCCACATTCTAGGTAGGTAG
GGGCCCACTTCACCGTACTAACCAGGGAAGCTGTCCCTCATGTTGAATTTTCTCTAACTTCAAGGCCCAT
ATCTGTGAAATGCTGGCATTTGCACCTACCTCACAGAGTGCATTGTGAGGGTTAATGAAATAATGTACAT
CTGGCCTTGAAACCACCTTTTATTACATGGGGTCTAAAACTTGACCCCCTTGAGGGTGCCTGTTCCCTCT
CCCTCTCCCTGTTGGCTGGTGGGTTGGTAGTTTCTACAGTTGGGCAGCTGGTTAGGTAGAGGGAGTTGTC
AAGTCTTGCTGGCCCAGCCAAACCCTGTCTGACAACCTCTTGGTCGACCTTAGTACCTAAAAGGAAATCT
CACCCCATCCCACACCCTGGAGGATTTCATCTCTTGTATATGATGATCTGGATCCACCAAGACTTGTTTT
ATGCTCAGGGTCAATTTCTTTTTTCTTTTTTTTTTTTTTTTTTCTTTTTCTTTGAGACTGGGTCTCGCTT
TGTTGCCCAGGCTGGAGTGGAGTGGCGTGATCTTGGCTTACTGCAGCCTTTGCCTCCCCGGCTCGAGCAG
TCCTGCCTCAGCCTCCGGAGTAGCTGGGACCACAGGTTCATGCCACCATGGCCAGCCAACTTTTGCATGT
TTTGTAGAGATGGGGTCTCACAGTGTTGCCCAGGCTGGTCTCAAACTCCTGGGCTCAGGCGATCCACCTG
TCTCAGCCTCCCAGAGTGCTGGGATTACAATTGTGAGCCACCACGTGGAGCTGGAAGGGTCAACATCTTT
TACATTCTGCAAGCACATCTGCATTTTCACCCCACCCTTCCCCTCCTTCTCCCTTTTTATATCCCATTTT
TATATCGATCTCTTATTTTACAATAAAACTTTGCTGCCA
MEEPQSDPSVEPPLSQETFSDLWKLLPENN
VLSPLPSQAMDDLMLSPDDIEQWFTEDPGP
DEAPRMPEAAPRVAPAPAAPTPAAPAPAPS
WPLSSSVPSQKTYQGSYGFRLGFLHSGTA
KSVTCTYSPALNKMFCQLAKTCPVQLWVDS
TPPPGTRVRAMAIYKQSQHMTEVVRRCPH
HERCSDSDGLAPPQHLIRVEGNLRVEYLDD
RNTFRHSVVVPYEPPEVGSDCTTIHYNYMC
NSSCMGGMNRRPILTIITLEDSSGNLLGRNS
FEVRVCACPGRDRRTEEENLRKKGEPHHE
LPPGSTKRALPNNTSSSPQPKKKPLDGEYF
TLQIRGRERFEMFRELNEALELKDAQAGKE
PGGSRAHSSHLKSKKGQSTSRHKKLMFKT
EGPDSD
http://www.uni-regensburg.de/Fakultaeten/Medizin/Chirurgie-Surgery/case_report.html
Pedigree
• Pedigree- the ancestry of an individual or
family.
For a tumor suppressor gene like p53 to play a role in
cancer transformation, both alleles need to be altered.
Example of a p53 Hereditary Pedigree
Leading Sites of New Cancer
Cases and Deaths
Breast Cancer
Prostate Cancer
Colon Cancer