Download Iodine Isotopes

Iodine Isotopes
 Chemistry & Radioactivity of Iodine
Moataz Mohamed
 Radioisotope Therapy (RIT-I131)
Rowan Mohamed
Mohamed Shady
‫البطاطس المضيئة ؟؟!!‬
‫البرسيم المشع ؟؟!!‬
I- Chemistry of Iodine
Discovery of Iodine
Discovery of
Iodine element
by
Bernard Courtois
in 1811
Physical Properties
• violet-dark gray solid
• Density: 5 g/cm3
• Melting Point: 114°C
• Boiling Point: 185°C
Atomic Properties
• Atomic Weight: 127
• Electrons/shell 2,8,18,18,7
• 53 Proton
• 74 Neutron
Occurrence on Earth
II- Radioactivity of Iodine
Iodine isotopes
• Isotopes are atoms of the same
element having the same
number of protons but different
number of neutrons.
• There are 37 isotopes of Iodine
Ex: I127, I129, I131 …
• The only stable isotope of Iodine is I127.
Radiation & Half-life Period
• If radiation is a form of energy ….. Then it can not be
created (First Low of Thermodynamics).
• So where does it come from???????????!
• The source of radiation is the loss in mass (E=MC2)
• Half-life period is the time after which the mass will
reach half of its initial value.
• Half-life period is very important in determining the
time needed for the radioactive substance to
completely decay.
III- Radioisotope Therapy
(RIT-I131)
Radiotherapy [ Iodine-131 ]
• Definition.
Medical use of IONIZING RADIATION in
treatment of Cancer and Malignant cells .
Radiotherapy Vs. Radiology ! !
• History of Radiotherapy :
Wilhelm Conrad Röntgen
Marie Curie
Radiotherapy [ Iodine-131 ]
• Mechanism of action :
 DAMAGE OF DNA..
Both strands ?
 Damage is inherited
in cancerous cells .
 Free radicals
( hydroxyl radicals ) .
Radiotherapy [ Iodine-131 ]
• Radioisotope Therapy ( RIT )
INFUSION
1. MIBG:
Neuroblastoma
2. ORAL IODINE 131:
Thyrotoxicosis
3. RADIOACTIVE
GLASS :
Hepatic cancer
INGESTION
Radiotherapy [ Iodine-131 ]
FELINE
HYPERTHYRODISM
• Procedure ..
• Advantages ..
• Disadvantages ..
Radiotherapy [ Iodine-131 ]
• Radiation protection.
Based on :
Time
Distance
Shielding
Radiotherapy [ Iodine-131 ]
1- Reducing the time of an exposure reduces the
effective dose proportionally.
2- Increasing distance reduces dose due to the
inverse square law .
3- Adding shielding can also reduce radiation
doses .
Thank You
References:
• http://en.wikipedia.org/wiki/Isotopes_of_io
dine
• Merck Index of Chemicals and Drugs, 9th
ed.
• General Chemistry (volume 2) by N.L.
Glinka, Mir Publishing 1981
• General Chemistry by Linus Pauling, 1947
ed.
• Chemical Supplier Convicted of Diversion
of Iodine
Moataz Mohamed
Rowan Mohamed
Muhamed Shady