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Systems model QL QTL QTL QTL QTL Phenotype Sub-systems model QL QTL QTL QTL QTL Phenotype •Genetical Genomics •Expression data •Genetic variation •Pathways underlying complex traits •Trait gene identification X 50 + 40 Test Statistic Disease challenge on F2 30 20 10 0 0 50 Test Statistic 40 30 20 10 0 0 50 100 150 cM “Genetical Genomics” 100 150 cM QTL study AND gene expression study in cross Is QTL also an eQTL? 50 Cis and trans effects Additional eQTL