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CURRICULUM VITAE
Rajan P. Nair, Ph.D.
Associate Research Scientist
Department of Dermatology Michigan
7421 Medical Science Building I, SPC 5675
1301 East Catherine St.
Ann Arbor, MI 48109-5675
Telephone: 734-764-4535
Fax: 734-763-4575
E-mail: [email protected]
EDUCATION
1961 - 65
1965 - 67
1967 - 70
1970 - 72
1972 - 76
N.S.S. High School, Kattampak, Kerala, India
University of Kerala, Trivandrum, India, Pre-degree, (chemistry, biology, physics)
University of Kerala, Trivandrum, India, B.S. (chemistry major)
University of Kerala, Trivandrum, India, M.S. (chemistry)
University of Kerala, Trivandrum, India, Ph.D. (organic chemistry)
POSTDOCTORAL TRAINING
1980 - 83
1983 - 87
1987 - 91
Postdoctoral Fellow, Department of Endocrinology, Medical College of Georgia,
Augusta, GA
Postdoctoral Fellow, Department of Obstetrics and Gynecology, University of Michigan,
Ann Arbor, MI
Research Associate and Research Specialist, Howard Hughes Medical Institute,
University of Michigan, Ann Arbor, MI
ACADEMIC APPOINTMENTS
1991 - 96
Research Investigator and Lecturer, Department of Dermatology, University of Michigan,
Ann Arbor, MI
1996 - 2011 Research Assistant Professor, Department of Dermatology, University of Michigan,
Ann Arbor, MI
2011 - present Associate Research Scientist, Department of Dermatology, University of Michigan,
Ann Arbor, MI
RESEARCH INTERESTS
Identification and delineation of the genetic basis of psoriasis and psoriatic arthritis.
GRANTS
Present and Active
R01 AR065183-01 (Elder, J.T., PI)
NIH/NIAMS
Functional Genomics of Psoriasis
09/15/13 – 07/31/17
The major goal of this project is to identify causal variants from GWAS data in psoriasis and
demonstrate their functional effects.
R01 AR063611-03 (Elder, J.T., PI)
09/12/12 – 08/31/17
NIH/NIAMS
Genetics and Genomics of Psoriatic Arthritis
The major goal of this project is to identify genetic and genomic determinants of psoriatic arthritis.
Role: Co-Investigator
R01 AR42742-21 (Elder, J.T., PI)
09/1/09 – 08/31/15
NIH/NIAMS
Linkage Analysis of Familial Psoriasis
The major goal of this project is to identify the genetic determinant(s) of psoriasis
Role: Co-Investigator
R01 AR050511-11 (Elder, J.T., PI)
08/01/09 – 07/31/15
NIH/NIAMS
Identification of Psoriatic Arthritis Genes
The major of this project is to identify the MHC determinant(s) of psoriatic arthritis
Role: Co-Investigator
AWARDS/HONORS
Eugene M. Farber Research in Psoriasis Award, Society for Investigative Dermatology, 2007
MEMBERSHIPS AND OFFICES IN PROFESSIONAL SOCIETIES
1992 - present
1992 - present
Society for Investigative Dermatology
American Society of Human Genetics
EDITORIAL POSITIONS AND PEER-REVIEW SERVICE
Editorial Committee Member: Latin American Journal of Psoriasis and Psoriatic Arthritis.
Reviewer for the following journals:
Archives of Dermatological Research
British Journal of Dermatology
Disease Markers
European Journal of Human Genetics
Human Genetics
Human Heredity
Journal of Dermatological Research
Journal of the European Academy of Dermatology and Venereology
Journal of Investigative Dermatology
Journal of Medical Genetics
Molecular and Cellular Probes
Pharmacogenomics
Tissue Antigens
Reviewer of research grants for:
Italian Telethon
Medical Research Council, UK
The Wellcome Trust, UK
National Eczema Foundation
NIAMS, NIH (Ad hoc reviewer)
TEACHING ACTIVITIES
1993-2008
Mentor, Undergraduate Research Opportunities Program,
mentored 1-2 students every year.
1994-present Mentored 1-2 postdoctoral fellows or graduate students every year.
COMMITTEE, ORGANIZATIONAL, AND VOLUNTEER SERVICE
2004- present Member, Institutional Review Board, University of Michigan Medical School,
reviews 1-5 human subject research protocols every week.
PRESENTATIONS
1. Genome Scan Identifies Four Susceptibility Loci for Psoriasis. American Society of Human Genetics
Annual Meeting, October 1997.
2. Identification of Psoriasis Susceptibility Loci. Department of Dermatology Research Conference, University
of Michigan, November 1997.
3. Multiple Susceptibility Loci for Psoriasis. International Psoriasis Congress, Milan, Italy, September 1998.
4. Michigan Psoriasis Research Progress. Psoriasis Gene Mapping Collaboration, Amsterdam, January 1998.
5. Fine Mapping of the Psoriasis Locus PSORS1. American Society of Human Genetics Annual Meeting,
October 2000.
6. Homing in on a Psoriasis Gene. Department of Dermatology Research Conference, University of Michigan,
January 2000.
7. Finding a Psoriasis Gene. Department of Dermatology Research Conference, University of Michigan,
September 2001.
8. Progress in Michigan Psoriasis Genetics Research. Michigan-Kiel Psoriasis Genetics Collaboration Annual
Meeting, Amsterdam, February 2001.
9. Fine mapping of chromosome 6 psoriasis locus. Michigan-Kiel Psoriasis Genetics Collaboration Annual
Meeting, Amsterdam, February 2002.
10. Michigan Psoriasis Research Progress. Michigan-Kiel Psoriasis Genetics Collaboration Annual Meeting,
Amsterdam, February 2003.
11. Finding a Disease Gene. Dermatology Dialogue Presentation, University of Michigan, August 2003.
12. Goals of the Michigan Psoriasis Genetics Project. Michigan-Kiel Psoriasis Genetics Collaboration Annual
Meeting, Amsterdam, March 2004.
13. Fine mapping a Psoriasis Gene and Gene Identification Strategies. Department of Dermatology Research
Conference, University of Michigan, September 2004.
14. Gene identification in the major psoriasis susceptibility locus on chromosome 6. Michigan-Kiel Psoriasis
genetics Collaboration Annual Meeting, Amsterdam, June 2005.
15. Analysis of non-MHC psoriasis susceptibility loci PSORS2, PSORS4, PSORS5, and PSORS8. MichiganKiel Psoriasis genetics Collaboration Annual Meeting, Amsterdam, February 2006.
16. Psoriasis candidate gene and MHC class III haplotype analysis. Michigan-Kiel Psoriasis Genetics
Collaboration Annual Meeting, Amsterdam, February 2007.
17. Genome Wide Association Study of psoriasis. Department of Dermatology Research Conference, University
of Michigan, January 2008.
18. Analysis of the Thai HLA-Cw1-B46 risk haplotype and fine mapping of PSORS2. Michigan-Kiel Psoriasis
Genetics Collaboration Annual Meeting, Amsterdam, February 2008.
19. Follow-up of Collaborative Association Study of Psoriasis (CASP). Dermatology Research Presentation,
University of Michigan, September 2008.
20. Replication of Association of ZNF313 Locus on Chromosome 20q13 with Psoriasis. Psoriasis Gene to
Clinic Conference, London, December 2008.
21. Progress in the Michigan Psoriasis Genetics Study. Michigan-Kiel Psoriasis Genetics Collaboration Annual
Meeting, Amsterdam, February 2009.
22. Following up on Genome Wide Association Study of psoriasis. Department of Dermatology Research
Conference, University of Michigan, September 2009.
23. Progress in the Michigan Psoriasis Genetics Study. Michigan-Kiel Psoriasis Genetics Collaboration Annual
Meeting, Amsterdam, February 2010.
24. Michigan Psoriasis Genetics Study: Recent Progress and Plans. Michigan-Kiel Psoriasis Genetics
Collaboration Annual Meeting, Amsterdam, February 2011.
25. Psoriasis Susceptibility Genes. Department of Dermatology Research Conference, University of Michigan,
November 2011.
26. First Pass Analysis of Immunochip Data. International Psoriasis and Arthritis Research Team annual
meeting, Toronto, November 2011.
27. Replication of Eighteen Psoriasis Genetic Associations in Psoriasis. Psoriasis Gene to Clinic conference in
London, December 2011.
28. Immunochip and psA GWAS Analysis Results. Progress and Plans. Michigan-Kiel Psoriasis Genetics
Collaboration Annual Meeting, Amsterdam, January 2012.
29. Psoriasis susceptibility genes. Medical Education Department, Toronto General Hospital, Toronto, ON, May
2012.
30. Genomic dissection of psoriasis and psoriatic arthritis - extension of IPART, International Psoriasis and
Arthritis Research Team annual meeting, Toronto, October 2012.
31. Michigan Psoriasis Genetics Study: Recent Progress and Plans. Michigan-Kiel Psoriasis Genetics
Collaboration Annual Meeting, Amsterdam, January 2013.
32. Designing a genetic association study. Department of Dermatology, All India Institute of Medical Sciences,
New Delhi, India, January 2013.
33. Genetic association of psoriasis and psoriatic arthritis. Department of Dermatology Research Conference,
University of Michigan, February 2013.
34. Meta-analysis of psoriasis and psoriatic arthritis identifies three new susceptibility loci. International
Investigative Dermatology meeting, Edinburgh, Scotland.
PATENT
Nair RP, Upadhyay VK, Bannore SN, Subbarao HN, Dev S. Mixture of cis pinanol and 3--4--epoxycarene.
Indian Patent No. 79/B0338. 120379, 1982.
BIBLIOGRAPHY
Peer-Reviewed Publications
1.
Joshua CP, Nair RP: Synthesis of amidinothioureas. Chemistry and Industry 1974:301.
2.
Joshua CP, Nair RP: Synthesis of biguanide. Chemistry and Industry 1974:497-498.
3.
Joshua CP, Nair RP: Interaction of dicyandiamide with thiocarbamide: formation of 2,4-diamino-6mercapto-s-triazine and biguanide. Indian J Chem 12:496-497, 1974.
4.
Joshua CP, Nair RP: Interaction of dicyandiamides with thioamides. Australian J Chem 27:2627-2634,
1974.
5.
Joshua CP, Nair RP: Interaction of dicyandiamides with thioureas. Australian J Chem 28:427-434, 1975.
6.
Joshua CP, Nair RP: Reaction of isothiocyanates with thiourea and amidinothioureas. Australian J Chem
29:415-425, 1976.
7.
Joshua CP, Nair RP: Reaction of dicyandiamide with thiosemicarbazide and thiocarbohydrazide.
Australian J Chem 29:1051-1058, 1976.
8.
Indukumari PV, Joshua CP, Nair RP: Oxidation and eliminative cyclization of S-alkylisothioureas. Indian
J Chem 20B:384-387, 1981.
9.
Nair RP, Bannore SN, Subbarao HN, Dev S: Ligand effects in epoxidations by hydroperoxides using
molybdenum catalysts: epoxidation of 3-carene. Tetrahedron 40:983-989, 1984.
10. Powell MM, Nair RP, Cohen JD, Bhalla VK: Gonadal receptors: upregulation in response to elevated
serum gonadotropin levels. Biol Reprod 25:708-718, 1981.
11. Nair RP, Powell MM, Burgett AC, Bhalla VK: Ethanol-induced release of adenosine 3',5'-monophosphate
into the medium by rat testis in vitro. Endocrinology 110:80-88, 1982.
12. Bhalla VK, Nair RP, Newman ME: Alcohol-induced luteinizing hormone receptor deficiency at the
testicular level. Alcoholism (NY) 7:153-162, 1983.
13. Nair RP, Menon KMJ: Involvement of microtubules in lipoprotein degradation and utilization for
progesterone production in cultured rat luteal cells. Endocrinology, 117:2408-2416, 1985.
14. Nair RP, Menon KMJ: Evidence that dissociation, not intracellular degradation, is the major pathway for
removal of receptor-bound human chorionic gonadotropin in cultured rat luteal cells. Biol Reprod, 33:6066, 1985.
15. Bhalla VK, Nair RP, Burgett AC, Sohal GS: Interstitial cell heterogeneity in rat testes Part I: purification
of collagenase dispersed Leydig cells by unit gravity sedimentation and demonstration of binding sites for
gonadotropin in light cells versus enhanced steroidogenesis in heavier cells. J Biol Chem 262:5313-5321,
1987.
16. Nair RP, Menon KMJ: Metabolism of high density lipoprotein in cultured rat luteal cells. Biochim
Biophys Acta 921:25-37, 1987.
17. Nair RP, Menon KMJ: Differential uptake and metabolism of free and esterified cholesterol from high
density lipoprotein in the rat ovary. Biochim Biophys Acta, 959:206-213, 1988.
18. Nair RP, Menon KMJ: Cholesterol flux between high density lipoproteins and cultured rat luteal cells.
Endocrinology, 124:1857-1862, 1989.
19. Ernst LK, Nair RP, Larsen RD, Ruff MM, Lowe JB: Stable expression of blood group H determinants and
GDP-L-fucose:b-D-galactoside 2-a-L-fucosyltransferase in mouse cells after transfection with human DNA.
J Biol Chem, 264:3436-3447, 1989.
20. Larsen RD, Nair RP, Ruff MM, Kukowska-Latallo J, Cummings RD, Lowe JB: Isolation of a cDNA
encoding murine UDP-galactose: b-D-galactosyl-1,4-N-acetyl-D-glucosaminide a-1,3-galactosyltransferase: Expression cloning by gene transfer. Proc Natl Acad Sci USA, 86:8227-8231, 1989.
21. Nair RP, Larsen RD, Ajmera S, Ernst LK, Lowe JB: A cloned human DNA restriction fragment
determines expression of a GDP-L-fucose:b-D-galactoside 2-a-L-fucosyltransferase in transfected cells. J
Biol Chem, 264:11158-11167, 1989.
22. Larsen RD, Ernst LK, Nair RP, Lowe JB: Molecular cloning, sequence, and expression of a human GDPL-fucose:-D-galactoside 2-a-L-fucosyltransferase cDNA that can form the H blood group antigen. Proc
Natl Acad Sci USA, 87:6674-6678, 1990.
23. Kukowska-Latallo J, Larsen RD, Nair RP, Lowe JB: A cloned human cDNA determines expression of a
mouse stage-specific embryonic antigen and the Lewis blood group a(1,3/1,4)fucosyltransferase. Genes
and Development, 4:1288-1303, 1990.
24. Lowe JB, Stoolman LM, Nair RP, Larsen RD, Berhendt T, Marks RM: ELAM-1-dependent cell adhesion
to vascular endothelium determined by a transfected human fucosyltransferase cDNA. Cell, 63:475-484,
1990.
25. Lowe JB, Kukowska-Latallo J, Nair RP, Larsen RD, Marks RM, Macher BA, Kelly RJ, Ernst LK:
Molecular cloning of a human fucosyltransferase gene that determines expression of the Lewis x and VIM2 epitopes but not ELAM-1-dependent cell adhesion. J Biol Chem, 266:17467-17477, 1991.
26. Dumas DP, Ichikawa Y, Wong C-H, Lowe JB, Nair RP: Enzymatic synthesis of sialyl Lex and derivatives
based on a recombinant fucosyltransferase. Biorganic & Medicinal Chemistry Letters, 1:425-431, 1991.
27. Lowe JB, Stoolman LM, Nair RP, Larsen RD, Behrend TL, Marks RM: A transfected human
fucosyltransferase cDNA determines biosynthesis of oligosaccharide ligand(s) for endothelial-leucocyte
adhesion molecule I. Biochem Soc Trans, 19:649-653, 1991.
28. Weston BW, Nair RP, Larsen RD, Lowe JB: Isolation of a novel human a(1,3)fucosyltransferase gene and
molecular comparison to the human Lewis blood group a(1,3/1,4)fucosyltransferase gene: syntenic,
homologous, non-allelic genes encoding enzymes with distinct acceptor substrate specificities . J Biol
Chem, 267:4152-4160, 1992.
29. Elder JT, Hammerberg C, Cooper KD, Kojima T, Nair RP, Ellis CN, Voorhees JJ: Cyclosporin A rapidly
inhibits epidermal cytokine expression in psoriasis lesions, but not in cytokine-stimulated cultured
keratinocytes. J Invest Dermatol 101:761-6, 1993.
30. Elder JT, Nair RP, Guo SW, Henseler T, Christophers E, Voorhees JJ: The genetics of psoriasis. Arch
Dermatol 130:216-224, 1994.
31. Elder JT, Nair RP, Voorhees JJ: Epidemiology and the genetics of psoriasis. J Invest Dermatol 102:24S27S, 1994.
32. Elder JT, Henseler T, Christophers E, Voorhees JJ, Nair RP: Of genes and antigens: the inheritance of
psoriasis. J Invest Dermatol 103:150S-153S, 1994.
33. Nair RP, Guo S-W, Jenisch S, Henseler T, Lange EM, Terhune M, Westphal E, Christophers E, Voorhees
JJ, Elder JT: Scanning chromosome 17 for psoriasis susceptibility: lack of evidence for a distal 17q locus.
Hum Hered 45:219-230, 1995.
34. Nair RP, Henseler T, Jenisch S, Stuart P, Bichakjian CK, Lenk W, Westphal E, Guo SW, Christophers E,
Voorhees JJ, Elder JT: Evidence for two psoriasis susceptibility loci (HLA and 17q) and two novel
candidate regions (16q and 20p) by genome-wide scan. Human Mol. Genetics, 6:1349-1356, 1997.
35. Bichakjian CK, Nair RP, Wu WW, Goldberg S, Elder JT: Prenatal exclusion of lamellar ichthyosis based
on identification of two new mutations in the transglutaminase1 gene. J Invest Dermatol 110:104-107,
1998.
36. Jenisch S, Henseler T, Nair RP, Guo SW, Westphal E, Stuart S, Kronke M, Voorhees JJ, Christophers E,
Elder JT: Linkage analysis of human leucocyte antigen (HLA) markers in familial psoriasis: strong
disequilibrium effects provide evidence for a major determinant in the HLA-B-C region. Am. J. Hum.
Genet. 63:191-199, 1998.
37. Jenisch S, Westphal E, Nair RP, Stuart P, Voorhees JJ, Christophers E, Krönke M, Elder JT, Henseler T:
Linkage disequilibrium analysis of familial psoriasis: identification of multiple disease-associated MHC
haplotypes. Tissue Antigens 53:135-146, 1999.
38. Jenisch S, Koch S, Henseler T, Nair RP, Elder JT, Watts CE, Westphal E, Voorhees JJ, Christophers E,
Krönke M: Corneodesmosin gene polymorphism demonstrates strong linkage disequilibrium with HLA
and association with psoriasis vulgaris. Tissue Antigens 54: 439-449, 1999.
39. Nair RP, Stuart P, Henseler T, Jenisch S, Chia NVC, Schork NJ, Kim J, Lim HW, Christophers E,
Voorhees JJ, Elder JT: Fine mapping of psoriasis susceptibility locus PSORS1 to a 60 kilobase interval
telomeric to HLA-C. Am J Hum Genet 66:1833-44, 2000.
40. Stoll SW, Chia NC, Nair RP, Woods TL, Stuart P, Henseler T, Jenisch S, Christophers E, Voorhees JJ,
Elder JT: S100A2 coding sequence polymorphism: characterization and lack of association with psoriasis.
Clin Exp Dermatol. 26:79-83, 2001.
41. Chia NV, Stuart P, Nair RP, Henseler T, Jenisch S, Lim HW, Christophers E, Voorhees JJ, Elder JT:
Variations in the HCR (Pg8) gene are unlikely to be causal for familial psoriasis. J Invest Dermatol.
116:823-4, 2001.
42. Nair RP, Stuart P, Ogura Y, Inohara N, Henseler T, Jenisch S, Christophers E, Voorhees JJ, Nuñez G,
Elder JT: Lack of association between NOD2 3020InsC frameshift mutation and psoriasis. J Invest
Dermatol 117:1671-1672, 2001. .
43. Elder JT, Nair RP, Henseler T, Jenisch S, Stuart P, Chia N, Christophers E, Voorhees JJ: The genetics of
psoriasis 2001: The odyssey continues. Arch Dermatol 137:1447-1454, 2001.
44. Stuart P, Malick F, Nair RP, · Henseler T, Lim HW, Jenisch S,· Voorhees JJ, Christophers E, Elder JT:
Analysis of phenotypic variation in psoriasis as a function of age at onset and family history. Arch
Dermatol Res 294:207–213, 2002.
45. Graham RR, Ortmann WA, Langefeld CD, Jawaheer D, Selby SA, Rodine PR, Baechler EC, Rohlf KE,
Shark KB, Espe KJ, Green LE, Nair RP, Stuart PE, Elder PE, King RA, Moser KL, Gaffney PM, Bugawan
TL, Erlich HA, Rich SS, Gregersen PK, Behrens TW: Visualizing Human Leukocyte Antigen Class II Risk
Haplotypes in Human Systemic Lupus Erythematosus. Am J Hum Genet 71:543-553, 2002.
46. Guo SW, Jenisch S, Stuart P, Lange EM, Kukuruga D, Nair R, Henseler T, Voorhees J, Christophers E,
Elder JT: Combined segregation and linkage analysis of HLA markers in familial psoriasis. Eur J Hum
Genet 10:327-33, 2002.
47. International Psoriasis Genetics Consortium (Allen M, Barker JNWN, Bowcock AM, Burden AD, Chia N,
Capon F, Christophers E, Daly MJ, Elder JT, Helms C, Henseler T, Jenisch S, Menter A, Mistry R, Nair
RP, Stuart PE, Tillman D, Trembath RC, Veal C, Voorhees JJ): The international psoriasis genetics study:
assessing linkage to 14 candidate susceptibility loci in a 942 affected-sib-pair cohort. Am J Hum Genet
73:430-437, 2003.
48. Sagoo GS, Tazi-Ahnini R, Barker JW, Elder JT, Nair RP, Samuelsson L, Traupe H, Trembath RC,
Robinson DA, Iles MM: Meta-Analysis of Genome-Wide Studies of Psoriasis Susceptibility Reveals
Linkage to Chromosomes 6p21 and 4q28-q31 in Caucasian and Chinese Hans Population. J Invest
Dermatol. 122:1401-405, 2004.
49. Elder JT, Nair RP, Weichenthal M, Stuart P, Voorhees JJ, Christophers E, Jenisch S: The MHC genes in
psoriasis. Current Genomics 6:39-43, 2005.
50. The Cluster 17 Collaboration (Abecasis G, Allen M, Barker JNWN, Burden D, Capon F, Christophers E,
Elder JT, Fischer J, Giardina E, Gudjonsson JE, Hüffmeier U, Jenisch S, Karason A, Kere J, Nair RP,
Novelli G, Prud’homme J-F, Qin ZS, Samuelsson L, Sanchez F, Saarialho-Kere U, Ståhle M, Stuart P,
Tilman D, Traupe H, Trembath R, Valdimarsson H, Veal C, Voorhees JJ, Weichenthal M): Fine mapping
of the psoriasis susceptibility gene PSORS1: A reassessment of risk associated with a putative risk
haplotype lacking HLA-Cw6). J Invest Dermatol 124:921-930, 2005.
51. Nistor I, Nair RP, Stuart PE, Hiremagalore R, Thompson RA, Jenisch S, Weichenthal M, Abecasis GR,
Qin S, Christophers E, Lim HW, Voorhees JJ, and Elder JT: Protein tyrosine phosphatase gene PTPN22
polymorphisms in psoriasis: lack of evidence for association. J Invest Dermatol 125:395-396, 2005.
52. Stuart PE, Nair RP, Abecasis GR, Nistor I, Hiremagalore R, Chia NV, Qin ZS, Thompson RA, Jenisch S,
Weichenthal M, Janiga J, Lim HW, Christophers E, Voorhees JJ, and Elder JT: Analysis of RUNX1
binding site and Raptor polymorphisms in psoriasis: no evidence for association despite adequate power
and evidence for linkage. J Med Genet 43:12-17, 2006.
53. Jenisch S, Hampe J, Elder JT, Nair R, Stuart P, Voorhees JJ, Schreiber S, Kabelitz D, Christophers E,
Weichenthal M: CARD15 mutations in patients with plaque-type psoriasis and psoriatic arthritis: lack of
association. Arch Dermatol Res 297:409-411, 2006.
54. Nair RP, Stuart P, Nistor I, Hiremagalore R, Chia NVC, Jenisch S, Weichenthal M, Abecasis G, Lim HW,
Christophers E, Voorhees JJ, Elder JT: Sequence and haplotype analysis supports HLA-C as the psoriasis
susceptibility gene. Am J Hum Genet 78:827-851, 2006.
55. Poynter JN, Elder JT, Fullen DR, Nair RP, Soengas MS, Johnson TM, Redman B, Thomas NE, Gruber
SB: BRAF and NRAS mutations in melanoma and melanocytic nevi. Melanoma Res 16:267-73, 2006.
56. Fullen DR, Poynter JN, Lowe L, Su LD, Elder JT, Nair RP, Johnson TM, Gruber SB: BRAF and NRAS
mutations in spitzoid melanocytic lesions. Mod Pathol 19:1324-32, 2006.
57. Verhaegen M, Bauer JA, Martin de la Vega C, Wang G, Wolter KG, Brenner JC, Nikolovska-Coleska Z,
Bengtson A, Nair R, Elder JT, Van Brocklin M, Carey TE, Bradford CR, Wang S, Soengas MS: A novel
BH3 mimetic reveals a mitogen-activated protein kinase-dependent mechanism of melanoma cell death
controlled by p53 and reactive oxygen species. Cancer Res. 66:11348-59, 2006.
58. Kia KF, Nair RP, Ike RW, Hiremagalore R, Elder JT, Ellis CN: Prevalence of antigliadin antibodies in
patients with psoriasis is not elevated compared with controls. Am J Clin Dermatol 8:301-5, 2007.
59. Weichenthal M, Ruether A, Schreiber S, Nair R, Voorhees JJ, Schwarz T, Kabelitz D, Christophers E,
Elder JT, Jenisch S: Filaggrin R501X and 2282del4 mutations are not associated with chronic plaque-type
psoriasis in a German cohort. J Invest Dermatol 127:1535-7, 2007.
60. Nair RP, Ruether A, Stuart PE, Jenisch S, Tejasvi T, Hiremagalore R, Schreiber S, Kabelitz D, Lim HW,
Voorhees JJ, Christophers E, Elder JT, Weichenthal M: Polymorphisms of the IL12B and IL23R Genes Are
Associated with Psoriasis. J Invest Dermatol 128:1653-61, 2008.
61. Gudjonsson JE, Aphale A, Grachtchouk M, Ding J, Nair RP, Wang T, Voorhees JJ, Dlugosz AA, Elder
JT: Lack of Evidence for Activation of the Hedgehog Pathway in Psoriasis. J Invest Dermatol 129:635-40,
2009.
62. Nair RP, Duffin KC, Helms C, Ding J, Stuart PE, Goldgar D, Gudjonsson JE, Li Y, Tejasvi T, Feng BJ,
Ruether A, Schreiber S, Weichenthal W, Gladman D, Rahman P, Schrodi SJ, Prahalad S, Guthery SL,
Fischer J, Liao W, Kwok P, Menter A, Lathrop GM, Wise C, Begovich AB, Voorhees JJ, Elder JT,
Krueger GG, Bowcock AM, Abecasis GR, et al.: Genome-wide Scan Reveals Association of Psoriasis with
IL-23 and NF-κB Pathways. Nat Genet 41:199-204, 2009.
63. de Cid R, Riveira-Munoz E, Zeeuwen PL, Robarge J, Liao W, Dannhauser EN, Giardina E, Stuart PE, Nair
R, Helms C, Escaramís G, Ballana E, Martín-Ezquerra G, den Heijer M, Kamsteeg M, Joosten I, Eichler
EE, Lázaro C, Pujol RM, Armengol L, Abecasis G, Elder JT, Novelli G, Armour JA, Kwok PY, Bowcock
A, Schalkwijk J, Estivill X: Deletion of the late cornified envelope LCE3B and LCE3C genes as a
susceptibility factor for psoriasis. Nat Genet 41:211-5, 2009.
64. Nair RP, Ding J, Duffin K., Helms C, Voorhees JJ, Krueger GG, Bowcock AM, Abecasis GR, and Elder
JT: Psoriasis bench to bedside: genetics meets immunology. Arch Dermatol 145:462-4, 2009.
65. Feng BJ, Sun LD, Soltani-Arabshahi R, Bowcock AM, Nair RP, Stuart P, Elder JT, Schrodi SJ, Begovich
AB, Abecasis GR, Zhang XJ, Callis-Duffin KP, Krueger GG, Goldgar DE: Multiple Loci within the major
histocompatibility complex confer risk of psoriasis. PLoS Genet 5:e1000606, 2009.
66. Gudjonsson JE, Ding J, Li X, Nair RP, Tejasvi T, Qin ZS, Ghosh D, Aphale A, Gumucio DL, Voorhees JJ,
Abecasis GR, Elder JT: Global Gene Expression Analysis Reveals Evidence for Decreased Lipid
Biosynthesis and Increased Innate Immunity in Uninvolved Psoriatic Skin. J Invest Dermatol 129:2795804, 2009.
67. Elder JT, Bruce AT, Gudjonsson JE, Johnston A, Stuart PE, Tejasvi T, Voorhees JJ, Abecasis GR, Nair
RP: Molecular Dissection of Psoriasis: Integrating Genetics and Biology. J Invest Dermatol 130:1213-16,
2010.
68. Nair RP, Stuart PE, Kullavanijaya P, Kullavanijaya P, Tejasvi T, Voorhees JJ, Elder JT: Genetic evidence
for involvement of the IL23 pathway in Thai psoriatics. Arch Dermatol Res 302:139-143, 2010.
69. Gudjonsson JE, Ding J, Johnston A, Tejasvi T, Guzman AM, Nair RP, Voorhees JJ, Abecasis GR, Elder
JT: Assessment of the Psoriatic Transcriptome in a Large Sample: Additional Regulated Genes and
Comparisons with In Vitro Models. J Invest Dermatol 130:1829-40, 2010.
70. Gudjonsson JE, Johnston A, Stoll SW, Riblett MB, Xing X, Kochkodan JJ, Ding J, Nair RP, Aphale A,
Voorhees JJ, Elder JT: Evidence for Altered Wnt Signaling in Psoriatic Skin. J Invest Dermatol 130:184959, 2010.
71. Stuart PE, Nair RP, Hiremagalore R, Kullavanijaya P, Kullavanijaya P, Tejasvi T, Lim HW, Voorhees JJ,
Elder JT: Comparison of MHC class I risk haplotypes in Thai and Caucasian psoriatics shows locus
heterogeneity at PSORS1. Tissue Antigens 76: 387-97, 2010.
72. Ellinghaus E, Ellinghaus D, Stuart PE, Nair RP, Debrus S, Raelson JV, Ding D, Li Y, Tejasvi T,
Gudjonsson J, Stephan Weidinger, Eberlein B, Kunz M, Rahman P, Gladman D, Gieger C, Wichmann HE,
Karlsen TH, Kabelitz D, Abecasis GR, Elder JT, Schreiber S, Weichenthal W, and Franke A:Genome-wide
association study identifies a psoriasis susceptibility locus at TRAF3IP2. Nat Genet 42:991-5, 2010.
73. Stuart PE*, Nair RP*, Ellinghaus E, Ding J, Tejasvi T, Gudjonsson JE, Li Y, Weidinger S, Eberlein B,
Gieger C, Wichmann HE, Kunz M, Ike R, Krueger GG, Bowcock AM, Mroweitz U, Lim HW, Voorhees
JJ, Abecasis GR , Weichental M, Franke A, Rahman P, Gladman D, and Elder JT: Genome-wide
association analyses identifies three psoriasis susceptibility loci. Nat Genet 42:1000-4, 2010.
*
co-first authors.
74. Sun LD, Wang Cheng Z-X, H, Zhang AP, Wang P-G, Xu J-H, Zhu Q-X, Zhou H-S, Buchert E, Zhang F-R,
Pu X-M, Yang X-Q, Zhang J-Z, Xu A-E, Wu R-N, L-M Xu, Peng L, Helms CA, Ren Y-Q, Zhang C, Zhang
S-M, Nair RP, Wang H-Y, Lin G-S, Stuart PE, Fan Chen X, G, Tejasvi T, Li P, Zhu J, Li Z-M, Ge H-M,
Weichenthal M, Ye W-Z, Zhang C, Shen S-K, Yang B-Q, Sun Y-Y, Li S-S, Lin Y, Jiang J-H, Li C-T, Chen
R-X, Cheng J, Jiang X, Zhang P, Song W-M, Tang J, Zhang H-Q, Sun L, Cui J, Zhang L-J, Tang B, Huang
F, Qin Q, Pei X-P, Zhou A-M, Shao L-M, Liu J-L, Zhang F-Y, Du W-D, Franke A, Bowcock AM, Elder
JT, Liu J-J, Yang S, Zhang X-J: Follow-up study identifies six novel psoriasis susceptibility loci in the
Chinese Han population. Nat Genet 42:1005-9, 2010.
75. Ding J, Gudjonsson JE, Liang L, Stuart PE, Li Y, Chen W, Weichenthal M, Ellinghaus E, Franke A,
Cookson W, Nair RP, Elder JT, Abecasis GR: Gene expression in skin and lymphoblastoid cells: Refined
statistical method reveals extensive overlap in cis-eQTL signals. Am J Hum Genet 87:779-89, 2010.
76. Riveira-Munoz E, He SM, Escaramís G, Stuart PE, Hüffmeier U, Lee C, Kirby B, Oka A, Giardina E, Liao
W, Bergboer J, Kainu K, de Cid R, Munkhbat B, Zeeuwen PL, Armour JA, Poon A, Mabuchi T, Ozawa A,
Zawirska A, Burden AD, Barker JN, Capon F, Traupe H, Sun LD, Cui Y, Yin XY, Chen G, Lim HW, Nair
RP, Voorhees JJ, Tejasvi T, Pujol R, Munkhtuvshin N, Fischer J, Kere J, Schalkwijk J, Bowcock A, Kwok
PY, Novelli G, Inoko H, Ryan AW, Trembath RC, Reis A, Zhang XJ, Elder JT, Estivill X: Meta-Analysis
Confirms the LCE3C_LCE3B Deletion as a Risk Factor for Psoriasis in Several Ethnic Groups and Finds
Interaction with HLA-Cw6. J Invest Dermatol 131:1105-9, 2011.
77. Swindell WR, Johnston A, Carbajal S, Han G, Wohn C, Lu J, Xing X, Nair RP, Voorhees JJ, Elder JT,
Wang XJ, Sano S, Prens EP, Digiovanni J, Pittelkow MR, Ward NL, Gudjonsson JE: Genome-wide
expression profiling of five mouse models identifies similarities and differences with human psoriasis.
PLoS One 6:e18266, 2011.
78. Tejasvi T, Stuart PE, Chandran V, Voorhees JJ, Gladman DD, Rahman P, Elder JT, Nair RP: TNFAIP3
gene polymorphisms are associated with response to TNF blockade in psoriasis. J Invest Dermatol 132:593600, 2012.
79. Ellinghaus E, Stuart PE, Ellinghaus D, Nair RP, Debrus S, Raelson JV, Belouchi M, Tejasvi T, Li Y, Tsoi
LC, Onken AT, Esko T, Metspalu A, Rahman P, Gladman DD, Bowcock AM, Helms C, Krueger GG,
Koks S, Kingo K, Gieger C, Wichmann HE, Mrowietz U, Weidinger S, Schreiber S, Abecasis GR, Elder
JT, Weichenthal M, Franke A: Genome-Wide Meta-Analysis of Psoriatic Arthritis Identifies Susceptibility
Locus at REL. J Invest Dermatol 132:1133-40, 2012.
80. Swindell WR, Xing X, Stuart PE, Chen CS, Aphale A, Nair RP, Voorhees JJ, Elder JT, Johnston A,
Gudjonsson JE: Heterogeneity of inflammatory and cytokine networks in chronic plaque psoriasis. PLoS
One 7:e34594, 2012.
81. Ellinghaus D, Ellinghaus E, Nair RP, Stuart PE, Esko T, Metspalu A, Debrus S, Raelson JV, Tejasvi T,
Belouchi M, West SL, Barker JN, Kõks S, Kingo K, Balschun T, Palmieri O, Annese V, Gieger C,
Wichmann HE, Kabesch M, Trembath RC, Mathew CG, Abecasis GR, Weidinger S, Nikolaus S, Schreiber
S, Elder JT, Weichenthal M, Nothnagel M, Franke A: Combined analysis of genome-wide association
studies for Crohn disease and psoriasis identifies seven shared susceptibility loci. Am J Hum Genet 90:63647, 2012.
82. Jordan CT, Cao L, Roberson ED, Duan S, Helms CA, Nair RP, Duffin KC, Stuart PE, Goldgar D, Hayashi
G, Olfson EH, Feng BJ, Pullinger CR, Kane JP, Wise CA, Goldbach-Mansky R, Lowes MA, Peddle L,
Chandran V, Liao W, Rahman P, Krueger GG, Gladman D, Elder JT, Menter A, Bowcock AM: Rare and
Common Variants in CARD14, Encoding an Epidermal Regulator of NF-kappaB, in Psoriasis. Am J Hum
Genet 90:796-808, 2012.
83. Stuart PE*, Hüffmeier U*, Nair RP*, Palla R, Tejasvi T, Schalkwijk J, Elder JT, Reis A, Armour JAL:
Association of β-defensin copy number and psoriasis in three cohorts of European origin. J Invest Dermatol
132:2407-13, 2012.
*
co-first authors.
84. Tsoi LC, West SL, Knight J, Ellinghaus E, Stuart PE, Capon F, Ding J, Li Y, Kang HM ...(36 others).....
Rahman P, Gladman DD, Griffiths CEM, Reis A, Kere J, Nair RP, Franke F, Barker JNWN, R Abecasis
GR, Elder JT, Trembath RC: Identification of 15 new psoriasis susceptibility loci highlights the role of
innate immunity. Nature Genetics 44:1341-8, 2012.
85. Johnston A, Xing X, Swindell WR, Kochkodan J, Riblett M, Nair RP, Stuart PE, Ding J, Voorhees JJ,
Elder JT, Gudjonsson JE: Susceptibility-associated genetic variation at IL12B enhances Th1 polarization in
psoriasis. Hum Mol Genet 22:1807-15, 2013.
86. Shaiq PA, Stuart PE, Latif A, Schmotzer C, Kazmi AH, Khan MS, Azam M, Tejasvi T, Voorhees JJ, Raja
GK, Elder JT, Qamar R, Nair RP: Genetic Associations of Psoriasis in a Pakistani Population. Br J
Dermatol 169:406-411, 2013.
87. Li B, Tsoi LC, Swindell WR, Gudjonsson JE, Tejasvi T, Johnston A, Ding J, Stuart PE, Xing X,
Kochkodan JJ, Voorhees JJ, Kang HM, Nair RP, Abecasis GR, Elder JT: Transcriptome Analysis of
Psoriasis in a Large Case-Control Sample: RNA-Seq Provides Insights into Disease Mechanisms. J Invest
Dermatol 134:1828-38, 2014.
88. Okada Y, Han B, Tsoi LC, Stuart PE, Ellinghaus E, Tejasvi T, Chandran V, Pellett F, Pollock R, Bowcock
AM, Krueger GG, Weichenthal M, Voorhees JJ, Rahman P, Gregersen PK, Franke A, Nair RP, Abecasis
GR, Gladman DD, Elder JT, de Bakker PI, Raychaudhuri S: Fine mapping major histocompatibility
complex associations in psoriasis and its clinical subtypes. Am J Hum Genet 95:162-72, 2014.
89. Das S, Stuart PE, Ding J, Tejasvi T, Li Y, Tsoi LC, Chandran V, Fischer J, Helms C, Duffin KC, Voorhees
JJ, Bowcock AM, Krueger GG, Lathrop GM, Nair RP, Rahman P, Abecasis GR, Gladman D, Elder JT:
Fine mapping of eight psoriasis susceptibility loci. Eur J Hum Genet. 2014 Sep 3.
doi:10.1038/ejhg.2014.172. [Epub ahead of print]
Non-Peer-Reviewed Publications
1.
Elder JT, Nair RP, Voorhees JJ. Epidemiology and the genetics of psoriasis. J Invest Dermatol 102:24S27S, 1994. (Review article)
2.
Elder JT, Henseler T, Christophers E, Voorhees JJ, Nair RP. Of genes and antigens: the inheritance of
psoriasis. J Invest Dermatol 103:150S-153S, 1994. (Review article)
Book Chapters
1.
Bhalla VK, Powell MM, Rojas FJ, Nair RP. Gonadotropin binding model: comparison of the binding
characteristics of cAMP to protein kinase holoenzyme and gonadotropin to particulate receptors in rat testis.
In: Function correlates of hormone receptors in reproduction, Mahesh VB, Muldoon TG (Ed), Elsevier
North-Holland, p. 419, 1981.
2.
Nair RP, Menon KMJ Role of microtubules in lipoprotein transport in cultured rat luteal cells In:
Lipoprotein and cholesterol metabolism in steroidogenic tissues. Strauss JF, Menon KMJ (Ed), George F
Stickley Press, p 197, 1985.
3.
Jenisch S, Nair RP, Henseler T, Elder JT, Marxen B, Kronke M, Westphal W: Association of Type I
psoriasis with the Cw*0802-DRB1*0102-DQB1*0501 haplotype in North American multiplex families. In:
12th International Histocompatibility Workshop and Conference Proceedings: Genetic diversity of HLA:
functional and medical implication. Charron, D(Ed), Serves: EDK, p 712-71, 1997.
Abstracts
1. Nair RP, Henseler T, Brenner KF, Voorhees JJ, Christophers E, Terhune M, Griffiths CEM, Elder JT: PCR
analysis of 73-alanine of HLA-C as a genetic marker for psoriasis. J Invest Dermatol 98:627A, 1992.
2. Henseler T, Koch F, Westphal E, Nair RP, Voorhees JJ, Elder JT, Christophers E: Presence of HLA- DR7
in the type I psoriasis. J Invest Dermatol 98:607A, 1992.
3. Nair RP, Henseler T, Lunetta K, Guo SW, Terhune M, Westphal E, Christophers E, Voorhees JJ, Elder JT:
Exclusion of tight linkage between familial psoriasis and HLA genes under a single gene, autosomal
dominant model. J Invest Dermatol 100:539A, 1993.
4. Henseler T, Westphal E, Jenisch S, Nair RP, Zavazava N, Elder JT, Voorhees JJ, Christophers E:
Mechanism of linkage disequilibrium between Cw6 and DR7 in type 1 psoriasis: Examples of inheritance in
trans. J Invest Dermatol 100:542A, 1993.
5. Nair RP, Kokx S, Henseler T, Jenisch S, Westphal E, Terhune M, Christophers E, Voorhees JJ, Elder JT:
DNA-based typing of HLA-Cw6, a human leukocyte antigen with increased frequency in type 1 psoriasis. J
Invest Dermatol 102:624A, 1994.
6. Nair RP, Jenisch S, Guo S-W, Henseler T, Kokx S, Terhune M, Woodbury M, Westphal E, Christophers E,
Voorhees JJ, Elder JT: Evidence for psoriasis susceptibility gene(s) on human chromosome 6p. J Invest
Dermatol 104:598A, 1995.
7. Henseler T, Elder JT, Nair R, Jenisch S, Lenk W, Westphal E, Voorhees JJ, Christophers E: Psoriasis and
HLA-Cw7 in a Caucasian family: Role of alanine 73. J Invest Dermatol 104:598A, 1995.
8. Jenisch S, Henseler T, Westphal E, Elder JT, Nair RP, Voorhees JJ, hristophers ,
ller-Ruchholtz W:
HLA-DQ9 (DQB1*0303) increases susceptibility to type 1 psoriasis in multiplex families, but only in the
presence of HLA-Cw6. J Invest Dermatol 104:629A, 1995
9. Nair RP, Henseler T, Jenisch S, Stuart P, Rasmussen B, Bichakjian C, Guo SW, Westphal E, Christophers
E, Voorhees JJ, Elder JT: A recombinant-based, genome-wide scan for psoriasis genes: The hunt continues.
J Invest Dermatol 106:905A, 1996.
10. Henseler T, Westphal E, Jenisch S, Nair RP, Zavazava N, Elder JT, Voorhees JJ, Christophers E:
Mechanism of linkage disequilibrium between Cw6 and DR7 in type 1 psoriasis: Examples of inheritance in
trans. J Invest Dermatol 100:542A, 1993.
11. Nair RP, Kokx S, Henseler T, Jenisch S, Westphal E, Terhune M, Christophers E, Voorhees JJ, Elder JT:
DNA-based typing of HLA-Cw6, a human leukocyte antigen with increased frequency in type 1 psoriasis. J
Invest Dermatol 102:624A, 1994.
12. Nair RP, Jenisch S, Guo S-W, Henseler T, Kokx S, Terhune M, Woodbury M, Westphal E, Christophers E,
Voorhees JJ, Elder JT: Evidence for psoriasis susceptibility gene(s) on human chromosome 6p. J Invest
Dermatol 104:598A, 1995.
13. Henseler T, Elder JT, Nair R, Jenisch S, Lenk W, Westphal E, Voorhees JJ, Christophers E: Psoriasis and
HLA-Cw7 in a Caucasian family: Role of alanine 73. J Invest Dermatol 104:598A, 1995.
14. Jenisch S, Henseler T, Westphal E, Elder JT, Nair RP, oorhees JJ, hristophers ,
ller-Ruchholtz W:
HLA-DQ9 (DQB1*0303) increases susceptibility to type 1 psoriasis in multiplex families, but only in the
presence of HLA-Cw6. J Invest Dermatol 104:629A, 1995
15. Nair RP, Henseler T, Jenisch S, Stuart P, Rasmussen B, Bichakjian C, Guo SW, Westphal E, Christophers
E, Voorhees JJ, Elder JT: A recombinant-based, genome-wide scan for psoriasis genes: The hunt continues.
J Invest Dermatol 106:905A, 1996.
16. Bichakjian CK, Wu WW, Elder JT, Nair RP: Two new mutations in the transglutaminase 1 gene in a
lamellar ichthyosis kindred. J Invest Dermatol Henseler T, Lenk W, Jenisch S, Westphal E, Nair RP, Elder
JT, Voorhees JJ, Christophers E: HLA class I haplotypes in multiplex families with type I psoriasis. J Invest
Dermatol 106:935A, 1996.
17. Elder JT, Jenisch S, Westphal, Henseler T, Nair RP, Guo S-W, Stuart P, Lenk W, Bichakjian C, Voorhees
JJ, Christophers E: Familial psoriasis is linked to HLA - B and -C. J Invest Dermatol 108:561A, 1997
18. Bichakjian CK, Nair RP, Elder JT: Successful antenatal diagnosis of lamellar ichthyosis. J Invest Dermatol
108:599A, 1997.
19. Nair RP, Henseler T, Jenisch S, Stuart P, Bichakjian C, Lenk W, Guo S-W, Westphal E, Malvitz E, Kim H,
Christophers E, Voorhees JJ, Elder JT: Candidate susceptibility loci for familial psoriasis. J Invest Dermatol
108:645A, 1997
20. Nair RP, Henseler T, Jenisch S, Stuart P, Bichakjian CK, Lenk W, Westphal E, Malvitz , Christophers E,
Voorhees JJ, Elder JT: Genome scan identifies four susceptibility loci for psoriasis. Am J Hum Genet
61:A42, 1997.
21. Elder JT, Jenisch S, Westphal E, Henseler T, Nair RP, Stuart P, Guo SW, Voorhees JJ, Christophers E:
Strong linkage disequilibrium localizes psoriasis susceptibility to within 0.4 Mb of HLA-C. Am J Hum
Genet 61:A274, 1997. 1998.
22. Nair RP, Henseler T, Jenisch S, Stuart P, Chia N, Westphal E, Malvitz E, Christophers E, Voorhees JJ,
Elder JT: Mapping of psoriasis susceptibility locus to a 330 KB region of centromeric HLA class I (6p21.3)
by linkage disequilibrium analysis. J Invest Dermatol 110: 615A, 1998.
23. Jenisch S, Elder JT, Westphal E, Nair RP, Christophers E, Krönke M, Henseler T: Localization of a
psoriasis vulgaris susceptibility allele on specific ancestral HLA-haplotypes. J Invest Dermatol 110: 619A,
1998. 76. Stoll SW, Sciabica M, Wiesen J, Werb Z, Elder JT: Induction of HB-EGF mRNA is intact in skin
organ cultures of EGFR knockout mice. J Invest Dermatol 110: 625A, 1998.
24. Nair RP, Stuart P, Henseler T, Jenisch S, Chia N, Westphal E, Arndt J, Epperson J, Christophers E,
Voorhees JJ, Elder JT: Linkage disequilibrium mapping of psoriasis susceptibility locus PSORSI on
chromosome 6. J Invest Dermatol 112: 640A, 1999.
25. Chia NVC, Elder JT, Nair RP: Use of a new mutation detection technique to identify genetic mutation in a
lamellar ichthyosis family. J Invest Dermatol 112: 593A, 1999.
26. Nair RP, Chia NVC, Jenisch S, Stuart P, Epperson J, Henseler T, Westphal E, Arndt JL, Christophers E,
Voorhees JJ, Elder JT: Investigation of TCF19 as a candidate gene for psoriasis susceptibility. Am J Human
Genet 65:A463, 1999.
27. Nair RP, Chia NVC, Stuart PE, Henseler T, Jenisch S, Westphal E, Arndt JL, Epperson J, Christophers E,
Voorhees J, Elder J: Investigation of OTF3 and TCF19 as candidate genes for psoriasis susceptibility. J
Invest Dermatol 114: 452A, 2000.
28. Chia NVC, Stoll SW, Woods TL, Nair RP, Stuart P, Elder JT: S100A2 sequence polymorphism is not
associated with psoriasis. J Invest Dermatol 114: 713A, 2000.
29. Nair RP, Stuart P, Henseler T, Jenisch S, Chia NVC, Westphal E, Schork NJ , Kim J, Lim HW,
Christophers E, Voorhees JJ, Elder JT : Phenotypic characterization of the EH57.1 disease allele at psoriasis
susceptibility locus PSORS1. Am J Hum Genet 67 (4) Suppl 2: 47A, 2000.
30. Nair R, Chia N, Shahabi L, Stuart P, Henseler S, Christophers E, Voorhees H, Elder J: Sequence variation
in a retrovirus-like expressed sequence tag in the PSORS1 critical region of the MHC: Lack of evidence for
a causative psoriasis gene. J Invest Dermatol 117: 513A, 2001.
31. Chia N, Stuart P, Nair RP, Henseler T, Lim H, Jenisch S, Christophers E, Voorhees J, Elder J: Analysis of
HCR gene polymorphism in familial psoriasis: Evidence against a causal role. J Invest Dermatol 117: 514A,
2001.
32. Elder J, Malick F, Stuart P, Lim H, Nair RP, Jenisch, Christophers E, Voorhees, J: Differential relationship
of disease severity to age of onset in familial vs. sporadic psoriasis. J Invest Dermatol 117: 514A, 2001.
33. Nair RP, Stuart P, Chia N, Epperson J, Nistor I, Henseler T, Jenisch S, Christophers E, Voorhees J, Elder J:
Analysis of the deletion of a tandem repeat sequence in human STG gene in psoriasis. J Invest Dermatol
117: 262A, 2002.
34. Elder JT, Barker JN, Burden D, Chia N, Christophers E, Daly M, Helms C, Henseler T, Jenisch S, Menter
A, Mistry R, Nair RP, Stuart P, Tillman D, Veal C, Voorhees JJ, Trembath R, Bowcock AM: Linkage of
psoriasis to the MHC and evidence for additional loci in the large cohort (International Psoriasis Genetics
Consortium). J Invest Dermatol 117: 266A, 2002.
35. Elder JT, Poynter J, Ge C, Johnson J, Nair RP, Redman B, Soengas M, Gruber S: BRAF exon 15 mutations
in melanoma: presence in primary melanomas and evidence for constitutive ERK activation in the absence
of mutation. J Invest Dermatol 121: 0166A, 2003.
36. Nair RP, Stuart P, Epperson, J, Nistor I, Dubal N, Weichenthal M, Jenisch S, Christophers E, Voorhees JJ,
Elder JT: Genomic Sequence analysis of PSORSI. J Invest Dermatol 121: 0611A, 2003.
37. Eymess A, Weichenthal M, Wedler M, Nair RP, Elder JT, Voorhees JJ, Christophers E, Kabelitz D, Jenisch
S: Analysis of the MIC-B polymorphism and its association with psoriasis. Genes and Immunity 4 (Suppl):
S6, 2003
38. Nair RP, Stuart P, Nistor I, Kullavanijaya P, Weichenthal M, Jenisch S, Christophers E, Voorhees JJ, Elder
JT: Sequence analysis of PSORS1 candidate genes: Only HLA-C and CDSN encode proteins unique to risk
haplotypes. J. Invest Dermatol 122: 495A, 2004.
39. Hiremagalore R, Nair RP, Stuart P, Nistor I, Thompson R, Jenisch S, Weichenthal M, Christophers E, Lim
H, Voorhees J, Elder JT: Lack of association of VEGF 405G/C polymorphism with psoriasis. J Invest
Dermatol 124: A79, 2005
40. Nair RP, Stuart P, Hiremagalore R, Nistor I, Thompson R, Jenisch S, Weichenthal M, Christohers E,
Abecasis G, Qin Z, Lim H, Voorhees J, Elder JT: Lack of association of psoriasis with RUNX1 and
RAPTOR polymorphisms in PSORS2 locus on chromosome 17. J Invest Dermatol 124: A79, 2005
41. Nistor I, Nair RP, Stuart P, Hiremagalore R, Thompson R, Jenisch S, Weichenthal M, Christophers E, Lim
H, Voorhees J, Elder JT: Protein tyrosine phosphatase gene PTPN22 polymorphism is not associated with
psoriasis. J Invest Dermatol 124: A80, 2005
42. Gudjonsson JE, Ding J, Nair RP, Abecasis G, Voorhees JJ, Elder JT: Global gene expression analysis of
psoriasis reveals differences between normal and uninvolved skin. J Invest Dermatology 126 (suppl): 14,
2006
43. Hiremagalore R, Inohara N, Nair RP, Stuart PE, Jenisch S, Weichenthal M, Lim HW, Christophers E,
Voorhees JJ, Nunez G, Elder JT: Genetic association analysis of NOD27 as a candidate gene psoriasis
susceptibility. J Invest Dermatology 126 (suppl): 80, 2006
44. Nair RP, Stuart PE, Nistor I, Hiremagalore R, Jenisch S, Weichenthal M, Abecasis GR, Lim HW,
Christophers E, Voorhees JJ, Elder JT: Genomic sequencing and haplotype analysis identify HLA-C as the
PSORS1 gene. J Invest Dermatolgy 126 (suppl): 84, 2006
45. Tejasvi T, Nair RP, Stuart P , oorhees JJ, lder JT:
perspective. J Invest Dermatology 127 (suppl): 357, 2007
ffectiveness of psoriasis treatments: a patients’
46. Nair RP, Stuart PE, Qin AZ, Abecasis GR, Jenisch S, Weichenthal M, Lim HW, Christophers E, Voorhees
JJ, Elder JT: Fine mapping of psoriasis susceptibility locus PSORS2 on chromosome17q. J Invest
Dermatology 126 (suppl): 533, 2007
47. Gudjonsson J, Tejasvi T, Aphale A, Stoll S, Nair R, Voorhees, J, Elder JT: Differences in the expression of
HLA class I molecules in uninvolved and involved psoriatic skin. J Invest Dermatol 127 suppl 2, S72 (2007)
48. Weichenthal M, Nair RP, Ruether A, Stuart PE, Schreiber S, Christophers E, Voorhees J, Elder JT, Jenisch
S: Polymorphisms of the IL12B and IL23R genes are associated with psoriasis. J Invest Dermatol 127 suppl
2, S86 (2007)
49. Tejasvi T, Stuart PE, Nair RP, Voorhees JJ, Elder JT: Initial pharmacogenomic assessment of TNF-alpha
and TRAF1 ploymorphisms in psoriasis: response to TNF blockers and other systemic therapies. J Invest
Dermatol 128, suppl 1, A442, 2008.
50. Nair RP, Stuart PE, Kullavanijaya P, Kullavanijaya P, Tejasvi T, Voorhees JJ, Elder JT: Genetic evidence
for involvement of the IL23 pathway in Thai psoriatics. J Invest Dermatol 128, suppl 1, A678, 2008.
51. Elder JT, Callis Duffin K, Helms C, Stuart PE, Ding J, Goldgar D, Tejasvi T, Gudjonsson JE, Liao W,
Menter A, Voorhees JJ, Abecasis GR, Nair RP, Bowcock AM, Krueger GG: Genome-wide association scan
reveals novel psoriasis susceptibility loci. J Invest Dermatol 128, suppl 1, A747, 2008.
52. Gudjonsson JE, Ding J, Nair RP, Stuart PE, Aphale A, Tejasvi T, Voorhees JJ, Abecasis GR, Elder JT:
Global gene expression analysis reveals evidence for abnormal lipid biosynthesis in uninvolved psoriatic
skin. J Invest Dermatol 128, suppl 1, A768, 2008.
53. Tejasvi T, Stuart PE, Nair RP, Voorhees JJ, Elder JT: Polymorphisms in TNFAIP3 as a predictor of
response to TNF blockage in psoriasis. J Invest Dermatol 129, suppl 1, A327, 2009.
54. Nair RP, Stuart PE, Hiremagalore R, Kullavanijaya P, Tejasvi T, Voorhees JJ, Elder JT: Analysis of the
HLA-Cw1-B46 psoriasis risk haplotype reveals allelic herogeneity with HLA-Cw6. J Invest Dermatol 129,
suppl 1, A489, 2009.
55. Feng B, soltani-Arabshi R, Bowcock AM, Nair RP, Elder JT, Schrodi SJ, Begovich AB, Abecasis GR,
Callis-Duffin KP, Goldgar DE, Krueger GG: Multiple independent loci within the major histocompatibility
complex confer risk of psoriasis. J Invest Dermatol 129, suppl 1, A510, 2009.
56. Nair RP, Stuart PE, Voorhees JJ, Elder JT: Haplotype analysis implicates MICA*002 in susceptibility to
psoriatic arthritis. J Invest Dermatol 129, suppl 1, A532, 2009.
57. Gudjonsson JE, Ding J, Nair RP, Liang L. Voorhees JJ, Abecasis GR, Elder JT: A genome-wide association
study of gene expression in skin and psoriatic lesions. J Invest Dermatol 129, suppl 1, A535, 2009.
58. Gudjonsson JE, Ding J, Johnston A, Guzman A, Nair RP, Voorhees JJ, Abecasis GR, Elder JT:
Comprehensive analysis of the psoriatic transcriptome and comparison with previous studies and cytokine
models. J Invest Dermatol 129, S49-S49, 2009.
59. Schrodi SJ, Li YH, Chang M, Garcia VE, Duffin KC, Nair RP, Bowcock AM, Elder JT, Krueger GG,
Rowland CM: Trait Prediction Using Multi-Locus Information: Psoriasis as a Model for Complex Disease
Prognostics. Genetics Epidemiology 33, 759-760, 2009.
60. Stuart PE, Nair RP, Buchert E, Ding J, Tejasvi T, Gudjonsson JE, Li Y, Abecasis GR, Krueger GG,
Bowcock AM, Voorhees JJ, Weichental M, Franke A, Rahman P, Gladman DD, Elder JT: genome-wide
association scan identifies twelve susceptibility loci for psoriasis and/or psoriatic arthritis. Clin Exp
Rheumatol 28: 604-604, 2010.
61. Gudjonsson JE, Xing X, Nair RP, Voorhees JJ, Johnston A, Elder JT: The psoriasis associated IL12B risk
haplotype influences IL-12 and IL-23 expression and secretion. J Invest Dermatol 13: S20-S20, 2010.
62. Tejasvi T, Stuart PE, Nair RP, Voorhees JJ, Elder JT: Interaction between psoriasis susceptibility loci
ERAP1 and HLA-Cw6. J Invest Dermatol 131:S65-S65, 2011.
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