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Birth of Two Chimeric Genes in the Hominidae Lineage
by Anouk Courseaux, and Jean-Louis Nahon
Science
Volume 291(5507):1293-1297
February 16, 2001
Published by AAAS
Figure 1 (A) Extent of the homology between the MCH/AROM locus on 12q24 and the PMCHLloci
on 5p14/5q13.
Anouk Courseaux, and Jean-Louis Nahon Science
2001;291:1293-1297
Published by AAAS
Figure 2 Schematic representation of the PMCHLtranscripts and potentially functional ORFs. (A)
Sense and antisense unspliced mRNA products.
Anouk Courseaux, and Jean-Louis Nahon Science
2001;291:1293-1297
Published by AAAS
Figure 3 (A) Genomic structural organization of the PMCHL genes. 15.4-kb of genomic sequence
from both PMCHL loci was obtained by direct sequencing (both forward and reverse strands) of
the 5p14-specific 283L20 and the 5q13-specific 484D2 BAC clones bearing the PMCHL1
andPMCHL2 loci, respectively (12).
Anouk Courseaux, and Jean-Louis Nahon Science
2001;291:1293-1297
Published by AAAS
Figure 4 Phylogenetic analysis of the intron-exon boundaries and poly(A) signals of the PMCHL
gene.
Anouk Courseaux, and Jean-Louis Nahon Science
2001;291:1293-1297
Published by AAAS
Figure 5 Proposed model for the emergence of the chimeric PMCHL1 and PMCHL2 genes during
primate evolution.
Anouk Courseaux, and Jean-Louis Nahon Science
2001;291:1293-1297
Published by AAAS
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