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Transcript 
Crossing Divergent Boundaries
Adam G. Marsh
University of Delaware
Environmental Bioinformatics
CCGG
CGTG
GAAG
1. Drill Hole
2. Go Swimming
Low Diversity, but high biomass marine invertebrate
communities
Photo Norbert Wu
Food Limitation
Photo Norbert Wu
ATAT
GCCT
CATA
Photo
Photo
courtesy
Rob robbins
Rob Robbins
GGCA
TCCT
CATC
Photo courtesy Norbert Wu
Photo Norbert Wu
Synthetic Biology Computational
Platform
Directed
Evolution
Of Genes
And Proteins
Population-scale evolution in the
Cloud
• Competition for CPU resources among 1000
genes/proteins drives evolution design efficiency
Evolution with Structure Selection
Evolution of Color
AGCTTCGCGGCTATAGGCTAGGCTATAGGCGCGCG
GCTAGGCTAGTGCTGTAGCTGCTGCTGATCCGGGC
TATCATATGCTGCTATTATATATACGCCATCGTAGCTA
GCTAGCGGCTAGCTATCATTACGGCGGCATTATATA
GCCGCGCTATATGCGTAGCTAGCGGCGTAGTCGAT
CGTAGCTGGGCTATAGCGCGTAGCTATAGGCTAGCT
AGCTGGCGGCGCGCGCGACTATATATGCTAGCTAG
CTAGCTGTCGATGTAGCGACTGATCGTAGCTAGCTG
ATCGTCGTGCGATGCTAGTC
Is this a GENE?
Is this ART?
Directed Evolution
> Pixel color is coded by three channels: R, G, B
Babel Color
PEPCO: Art in the Air
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