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Genetics News • Summary for Exam II - Do it NOW! • Office hours underutilization • Problem Set 7 available • Problem Set 8 available • Exam I … not available Our answers and comments on web. Click on Course at a Glance; then Click on Exams; Answer Keys Topics for Today • Sex linkage/Sex limitation •Calculation of probabilities from pedigree • Extension of Mendelian Genetics - Multiple alleles determining one trait - Multiple genes determining one trait - Multiple genes with additive effect Study Question 6 How is the trait inherited? Dd Dd Dd x Autosomal dominant Study Question 6 How is the trait inherited? Dd Dd Dd Dd dd dd Autosomal dominant Dd Dd dd x Autosomal recessive Study Question 6 How is the trait inherited? XDY XXD Autosomal dominant XDY Autosomal recessive x Sex-linked dominant Study Question 6 How is the trait inherited? XXd Autosomal dominant XY XXd XdY XXd XY XdY XdY Autosomal recessive Sex-linked dominant Sex-linked recessive Study Question 6 Could it be an autosomal dominant trait limited to males? Dd Dd Yes dd Dd Dd Dd dd Dd Dd Study Question 8 What is the probability that IV.1 will get the disease? XXd Specify: P(III.2 x III.3 XdY) Parse: XXd ? XY XdY ? Probability = 1/8 P(III.2 is XXd) Solve: 1/2 ? AND P(III.2 passes Xd) 1/2 AND P(III.3 is XY) AND P(III.3 passes Y) 1 1/2 Multiple Genes/One Trait Conventional dihybrid cross AB Ab aB ab AB AABB AABb AaBB AaBb Ab AABb AAbb AaBb Aabb aB AaBB AaBb aaBB aaBb ab AaBb Aabb aaBb aabb Substrate1 Product1 A Substrate2 Product2 B Multiple Genes/One Trait Dihybrid cross of interacting genes AB Ab aB ab AB AABB AABb AaBB AaBb Ab AABb AAbb AaBb Aabb aB AaBB AaBb aaBB aaBb ab AaBb Aabb aaBb aabb Substrate1 Substrate2 A 9:3:3:1 = 9:7 Product B Multiple Genes/One Trait Dihybrid cross of interacting genes AB Ab aB ab AB AABB AABb AaBB AaBb Ab AABb AAbb AaBb Aabb aB AaBB AaBb aaBB aaBb ab AaBb Aabb aaBb aabb chorismate compound X M 9:3:3:1 = 9:7 tryptophan N Study Question 17 You cross a vermilion-eyed fly with a cinnibar-eyed fly to obtain F1 progeny, then you cross these progeny to get F2 progeny. What phenotypic ratio do you expect? Study Question 17 Dihybrid cross of interacting genes CV Cv cV cv CV CCVV CCVv CcVV CcVv Cv CCVv CCvv CcVv Ccvv cV CcVV CcVv ccVV ccVv cv CcVv Ccvv ccVv ccvv Substrate1 Substrate2 V Product C Study Question 17 Dihybrid cross of interacting genes CV Cv cV cv CV CCVV CCVv CcVV CcVv Cv CCVv CCvv CcVv Ccvv cV CcVV CcVv ccVV ccVv cv CcVv Ccvv ccVv ccvv Substrate1 Substrate2 V 9:?:?:? Product C Study Question 17 Dihybrid cross of interacting genes CV Cv cV cv CV CCVV CCVv CcVV CcVv Cv CCVv CCvv CcVv Ccvv cV CcVV CcVv ccVV ccVv cv CcVv Ccvv ccVv ccvv Substrate1 Substrate2 V 9:3:?:1 Product C Multiple Genes/One Trait Dihybrid cross of interacting genes CV Cv cV cv CV CCVV CCVv CcVV CcVv Cv CCVv CCvv CcVv Ccvv cV CcVV CcVv ccVV ccVv cv CcVv Ccvv ccVv ccvv Substrate1 Substrate2 V 9:3:3:1 = 9:3:4 Product C Study Question 19 Conventional dihybrid cross AB AB Ab aB ab AABB AABb AaBB AaBb Ab AABb AAbb AaBb Aabb aB AaBB AaBb aaBB aaBb ab AaBb Aabb aaBb aabb Substrate1 Product1 A Pathway where dihybrid cross gives 15:1 ratio? Substrate2 Product2 B Study Question 19 What kind of genetic situation can you imagine that would lead to a 15:1 phenotypic ratio? AB Ab aB ab AB AABB AABb AaBB AaBb Ab AABb AAbb AaBb Aabb aB AaBB AaBb aaBB aaBb ab AaBb Aabb aaBb aabb Substrate1 Product1 A 9:3:3:1 15 : 1 Substrate2 Product2 B Study Question 20 You find corn with kernels in the ratio: Yellow 247 Golden 154 Sickly green 23 Hypothesis? Hypothesis: One gene, multiple alleles AB x CD 1:(1:1):1= 1:2:1 Study Question 20 One gene hypothesis You find corn with kernels in the ratio: Yellow 247 Golden 154 Sickly green 23 TOTAL 424 A B C AC BC D AD BD 212 106 106 424 Unit = 424/4 = 106 Exp Obs Study Question 20 Two gene hypothesis You find corn with kernels in the ratio: Yellow 247 Golden 154 Sickly green 23 Hypothesis? Hypothesis: Two genes for one trait AaBb x AaBb 9:3:3:1 Study Question 20 Two gene hypothesis You find corn with kernels in the ratio: Yellow 247 Golden 154 Sickly green 23 TOTAL 424 AB Ab aB ab AB AABB AABb AaBB AaBb Ab AABb AAbb AaBb Aabb aB AaBB AaBb aaBB aaBb ab AaBb Aabb aaBb aabb 238.5 = 26.5 x 9 159 = 26.5 x 6 26.5 = 26.5 x 1 424 Unit = 424/16 = 26.5 Exp Obs
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