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1 The form of cell division by which GAMETES (SEX CELLS) with HALF the number of CHROMOSOMES are produced. DIPLOID (2n) HAPLOID (n) Meiosis is SEXUAL reproduction. TWO divisions (MEIOSIS I and MEIOSIS II). 2 Occurs only in GONADS (testes or ovaries). Male: SPERMATOGENESIS – creates 4 sperm Female: OOGENESIS – creates 1 egg or ova and 3 polar bodies that die 3 n=23 human sex cell sperm n=23 n=23 2n=46 diploid (2n) n=23 n=23 haploid (n) n=23 Meiosis I Meiosis II 4 Haploid (1n) n=23 human sex cell egg n=23 2n=46 diploid (2n) Meiosis I Polar Bodies (die) n=23 Meiosis II 5 Similar to mitosis interphase. G1 phase- Cell growth S phase- Chromosomes are replicated Each duplicated chromosome consists of two identical SISTER CHROMATIDS attached at their CENTROMERES. G2 phase- Cell prepares for cell division. 6 Nucleus chromatin and nucleolus visible. Nucleus cell membrane nucleolus 7 Pair of chromosomes (maternal and paternal) that are similar in shape and size. Homologous pairs (tetrads) carry GENES controlling the SAME inherited traits. Each locus (position of a gene) is in the same position on homologues. Humans have 23 pairs of homologous chromosomes: a. First 22 pairs are called autosomes b. Last pair are sex chromosomes 8 eye color locus eye color locus hair color locus hair color locus Paternal Maternal 9 XX chromosome - female XY chromosome - male 10 Cell division that reduces the chromosome number by onehalf. Four phases: a. Prophase I b. Metaphase I c. Anaphase I Prophase I d. Telophase I 11 Chromosomes condense. Synapsis occurs - Homologous chromosomes come together to form a tetrad. Tetrad is two chromosomes or four chromatids (sister and non-sister chromatids). 12 Homologous chromosomes sister chromatids Tetrad sister chromatids 13 Crossing over may occur between non-sister chromatids only during Prophase I Crossing over: segments of nonsister chromatids break and reattach to the other chromatid. Causes Genetic Recombination or gene exchange. Creates genetic variation. 14 nonsister chromatids site of crossing over Tetrad variation 15 Meiosis I Homologs separate 16 • • • • Nucleolus & nuclear membrane disappear Spindle fibers forms Chromosomes coil & Synapsis (pairing) occurs Tetrads form & Crossing over Occurs spindle fiber centrioles aster fibers TETRAD 17 •Tetrads align on the equator. •Independent assortment occurs – chromosomes separate randomly causing GENETIC RECOMBINATION Homologs line up at equator or metaphase plate 18 • • Homologous chromosomes separate and move towards the poles. Sister chromatids remain attached at their centromeres. Homologs separate 19 Each pole now has haploid (1n) set of chromosomes. Cytokinesis occurs and two haploid daughter cells are formed. 20 cytokinesis 21 Meiosis II Sister Chromatids Separate 22 No Interphase or very short No DNA Replication Remember: Meiosis II is similar to mitosis but 2 cells go through the process now. 23 Same as Prophase in mitosis Nuclear membrane & nucleolus disappear Chromosomes condense Spindle fibers forms 24 Same as Metaphase in mitosis Chromosomes (not homologs) line up at equator 25 Same as Anaphase in mitosis SISTER CHROMATIDS separate and move toward ends of each cell. 26 Same as Telophase in mitosis. Nuclei and Nucleoli reform, spindle disappears CYTOKINESIS occurs. Remember: FOUR HAPLOID DAUGHTER cells are produced. Called GAMETES (eggs and sperm) 1n Sperm cell fertilizes 1n egg to form 2n zygote 27 28 29 30