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Transcript 
Hemoglobin research and the origins of molecular
medicine
by Alan N. Schechter
Blood
Volume 112(10):3927-3938
November 15, 2008
©2008 by American Society of Hematology
Alan N. Schechter.
Alan N. Schechter Blood 2008;112:3927-3938
©2008 by American Society of Hematology
The X-ray determined structure of the hemoglobin molecule and a representation of its very high
concentration in the erythrocyte.
Alan N. Schechter Blood 2008;112:3927-3938
©2008 by American Society of Hematology
A diagram of the proposed evolutionary relationships of the human globin proteins as inferred
from sequence analyses.
Alan N. Schechter Blood 2008;112:3927-3938
©2008 by American Society of Hematology
A photograph of Max F. Perutz (1914-2002) demonstrating an early model of the structure of
hemoglobin.
Alan N. Schechter Blood 2008;112:3927-3938
©2008 by American Society of Hematology
A representation of nitric oxide (NO)/hemoglobin reactions in the arterial microcirculation.
Alan N. Schechter Blood 2008;112:3927-3938
©2008 by American Society of Hematology
The genomic structure of the clusters of α-like and β-like globin genes, on chromosomes 16 and
11, in human beings.
Alan N. Schechter Blood 2008;112:3927-3938
©2008 by American Society of Hematology
The timeline of the expression of the human globin genes from early stages of fetal development
to the changes that occur at birth and in the first year of life.
Alan N. Schechter Blood 2008;112:3927-3938
©2008 by American Society of Hematology
A diagram of the postulated effect of hydroxyurea in inhibiting hemoglobin S-polymerization, by
increasing hemoglobin F levels (shown as 25%) in each sickle erythrocyte and thus decreasing
the degree of microvascular obstruction at any oxygen level.
Alan N. Schechter Blood 2008;112:3927-3938
©2008 by American Society of Hematology
A simplified model of the developmental control of β-globin gene transcription at the embryonic,
fetal, and adult developmental stages (see Figures 5 and 6).
Alan N. Schechter Blood 2008;112:3927-3938
©2008 by American Society of Hematology
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