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bw • Describe the laws of independent assortment and of segregation Genetics Probability Genotype and Phenotype • Genotype is the Genetic Makeup of an organism (2 alleles, one from each parent) • Phenotype is its physical appearance (the trait that is expressed) – Humans can change their physical appearance but they still have the same phenotype • Homozygous- when both alleles are the same – Homozygous dominant (AA) – OR Homozygous Recessive (aa) • Heterozygous- when there are one of each allele – (Dominant is always expressed in the phenotype) • Probability can be expressed in a fraction or a percentage • Results are more likely to be accurate with more trials or offspring Monohybrid Crosses • Cross between two individuals that involves the genotype of the parents to predict the genotype of the offspring. • Punnett Squares are used to determine the offspring probability. • We are going to study the gene that determines whether or not a rat is born with hair. • H- is the allele that determines hairy rats • h- is the allele that determines bald rats • HH= hairy rats • Hh= hairy rats • Hh= bald rats • We are going to cross two homozygous dominant rats H H H H • Punnet square says all or their babies will be hairy and have the same genotype = homozygous dominant Two Homozygous recessive rats h h h h • Yess!!! All their babies will be bald!! Heteroygous + Heterozygous • Both rat parents are hairy, however their genotype carries the recessive allele • 3:1 Ratio • Hairy:Bald H h H HH Hh h Hh hh Homozygous recessive with heterozygous 50 % are hairy And 50% are hairless H h h Hh hh h hH hh • You do the last one yourself! • The Curve Ball! Incomplete Dominance • Mendel’s Peas showed Complete Dominance • This is almost always the case! • Incomplete Dominance is when two or more alleles influence the phenotype, resulting in an intermediate phenotype • One allele for a flower that is red and one allele for a flower to be white • When they are in their homozygous state they will express the expected phenotype • In the heterozygous state the flower will be pink ! Codominance • Both alleles are completely expressed in the phenotype in the heterozygous state • Horses have an allele for white and brown coats. Sometimes both are expressed. Dihybrid Cross • Homozygous Dominant Parent for Yellow and Round Pea crosses with a homozygous recessive Parent for green and wrinkled pea. • Make a key, Draw a dihybrid cross and find the ratio. • All the offspring will be round and yellow • AND!!!.... Heterozygous for both traits. • Good work !