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the biomarker company™ Delivering Biomarker Discovery Data to Customers and Collaborators using Posters Keith Joho, Ph.D. Vice President, Informatics and Bioanalytical Operations Spotfire User Conference 10-15-03 Biomarker Discovery Homocysteine Cholesterol PSA CRP ? ? Glucose TG Insulin HbA1C ? Her2 CD4+ Clinical Cells T-cells Phenotype Complex Systems Simple molecules metabolites carbohydrates steroids lipids peptides proteins protein complexes SurroMed Technologies: mRNA/genes cells Mass Spectrometry Low MW (Metabolome) Immunoassays Proteome Gene patients chip Cytometry (SurroScanTM cytometer) eCRF, eMR Spotfire User Conference 10-15-03 SurroMed Data Warehouse LIMS Oracle Clinical •eCRF •EMR ELISA Mass Spectrometry •Proteomic •Metabolomic Spotfire User Conference 10-15-03 Cytometry SurroStat™ Architecture CLIENTS HTTP/ HTTPS Web Server Sun ONE J2EE Application Server S-Plus AS JDBC SurroStat Posters ™ Decision Site Servlets EJB Spotfire User Conference 10-15-03 JSP Oracle SurroStat™ Spotfire Integration Spotfire User Conference 10-15-03 SurroMed Posters Architecture Customer A Publish HTTPS Customer B HTTPS DecisionSite Server DecisionSite Server Posters Posters (Production) (Internal) HTTPS Customer C User Profile Database Posters Repository Internet Spotfire User Conference 10-15-03 DMZ Posters Repository User Profile Database Surromed Internal Network Data Warehouse