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Mendelian pedigree patterns further complications imprinting Mendelian pedigree patterns further complications imprinting Paternal imprinting: normal function of gene A is associated with epigenetic inactivation of the paternal allele Maternal imprinting: normal function of gene A is associated with epigenetic inactivation of the maternal allele Mendelian pedigree patterns further complications imprinting Disease phenotype caused by • imprinting of the nonimprinted allele • loss of imprint Example Phenotype arises only through male transmission Mendelian pedigree patterns further complications P- M+ P- M+ erase imprint paternal imprint P- M+ P- M*+ P- M+ erase imprint paternal imprint P*+ M+ P- M+
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