Download Slide 1

AGING & CANCER
Gene loss
DNA Repair
Proteasome
telomare
STOP CYCLE/AGING
ENVIRONMENTAL
STRESS
mutation
silencing and expressing gene
CANCER
Aging as a catabolic malfunction
and
“Garbage Catastrophe”
Young and clean
Oxidative damage
Proteosomal
degradation
Old and Dirty
Oxidative damage
Proteosomal
degradation
“Garbage
catastrophe”
Oxidized and
cross-linked
proteins
Anti-aging
Oxidized and
cross-linked
proteins
(Lipofuscin)
Reversing the catastrophe
Gene loss
DNA Repair
Proteasome
telomare
STOP CYCLE/AGING
ENVIRONMENTAL
STRESS
mutation
silencing and expressing gene
CANCER
ENVIRONMENTAL FACTOR

Nutrition
breast, ovaries



cigaretes
larynx, liver,
alchohol

excess calories
cancers of colon, rectum, stomach,
excess fat consumtion
obesity
1/3 of cancer deaths
Cancers of lung, pancreas, mouth,
esophagus and bladder

occupation

5% of cancerdeaths

Radiation

Other

cancers of lung, bladder, stomach, blood, liver,
bones, skin
3% /xray, uv, isotop
drug, virus, bacteri
blood and skin
various
Normal and Cancer cells contrast in their
proliferation capacity
Normal cells
Vs
Cancer cells
Limited number
of divisions
Unlimited number of
divisions
Permanent growth
arrest/senescence
Tumor
CANCER NEED MORE ENERGY
environmental stress
healty nutrient/suplement
HSF, HO-1, NOS,
P45OR (GENE
PROTECTOR)
necrotic
Apoptosis
p53, HSF
repair mechanism,
protecting cell
Cancer
interaction of genes between stressor and food cause cancer